• Co-diversification of an intestinal Mycoplasma and its salmonid host 

      Rasmussen, Jacob A.; Kiilerich, Pia; Madhun, Abdullah Sami; Waagbø, Rune; Lock, Erik Jan Robert; Madsen, Lise; Gilbert, Marcus Thomas Pius; Kristiansen, Karsten; Limborg, Morten T. (Peer reviewed; Journal article, 2023)
      Understanding the evolutionary relationships between a host and its intestinal resident bacteria can transform how we understand adaptive phenotypic traits. The interplay between hosts and their resident bacteria inevitably ...
    • Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts 

      Rasmussen, Jacob A.; Villumsen, Kasper Rømer; Duchêne, David; Puetz, Lara; Delmont, Tom; Sveier, Harald; von Gersdorff Jørgensen, Louise; Præbel, Kim; Martin, Michael David; Bojesen, Anders Miki; Gilbert, Marcus Thomas Pius; Kristiansen, Karsten; Limborg, Morten T. (Peer reviewed; Journal article, 2021)
      Salmonids are important sources of protein for a large proportion of the human population. Mycoplasma species are a major constituent of the gut microbiota of salmonids, often representing the majority of microbiota. Despite ...
    • Genomic context determines the effect of DNA methylation on gene expression in the gut epithelium of Atlantic salmon (Salmo salar) 

      Katirtzoglou, Aikaterini; Hansen, Søren B.; Sveier, Harald; Martin, Michael David; Brealey, Jaelle C.; Limborg, Morten T. (Peer reviewed; Journal article, 2024)
      The canonical view of DNA methylation, a pivotal epigenetic regulation mechanism in eukaryotes, dictates its role as a suppressor of gene activity, particularly within promoter regions. However, this view is being challenged ...
    • A holo-omics analysis shows how sugar kelp can boost gut health in Atlantic salmon 

      Rasmussen, Jacob A.; Bernhard, Annette; Lecaudey, Laurene Alicia; Kale, Varsha; Baldi, Germana; Myrmel, Lene Secher; Hansen, Martin; Brealey, Jaelle C.; Mak, Sarah S.T.; Nielsen, Ida B.; Richardson, Lorna; Madsen, Lise; Kristiansen, Karsten; Gilbert, M. Thomas P.; Martin, Michael David; Finn, Robert D.; Sveier, Harald; Limborg, Morten T. (Peer reviewed; Journal article, 2024)
      The projected growth of Aquaculture requires continuous optimisation of feeding regimes, especially in enhancing disease resilience through immunostimulating feed supplements. Seaweed has been introduced as a promising ...
    • Holo-Omics: Integrated Host-Microbiota Multi-omics for Basic and Applied Biological Research 

      Nyholm, Lasse; Koziol, Adam; Marcos, Sofia; Botnen, Amanda Bolt; Aizpurua, Ostaizka; Gopalakrishnan, Shyam; Limborg, Morten T.; Gilbert, Marcus Thomas Pius; Alberdi, Antton (Peer reviewed; Journal article, 2020)
      From ontogenesis to homeostasis, the phenotypes of complex organisms are shaped by the bidirectional interactions between the host organisms and their associated microbiota. Current technology can reveal many such interactions ...
    • Intestinal epigenotype of Atlantic salmon (Salmo salar) associates with tenacibaculosis and gut microbiota composition 

      Hansen, Søren B.; Bozzi, Davide; Mak, Sarah S.T.; Clausen, Cecilie G.; Nielsen, Tue K.; Kodama, Miyako; Hansen, Lars H.; Gilbert, Marcus Thomas Pius; Limborg, Morten T. (Journal article; Peer reviewed, 2023)
      It remains a challenge to obtain the desired phenotypic traits in aquacultural production of Atlantic salmon, and part of the challenge might come from the effect that host-associated microorganisms have on the fish ...
    • A practical introduction to holo-omics 

      Odriozola, Iñaki; Rasmussen, Jacob A.; Gilbert, Marcus Thomas Pius; Limborg, Morten T.; Alberdi, Antton (Journal article; Peer reviewed, 2024)
      Holo-omics refers to the joint study of non-targeted molecular data layers from host-microbiota systems or holobionts, which is increasingly employed to disentangle the complex interactions between the elements that compose ...