Browsing NTNU Open by Author "Lien, Egil"

Now showing items 1-11 of 11

    • A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling 

      Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Amy, Hise; Fitzgerald, Katherine A.; Espevik, Terje; Lien, Egil (Journal article; Peer reviewed, 2015)
      Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ...

    • Bacterial secretion systems and regulation of inflammasome activation 

      Ratner, Dmitry; Ørning, Mathias Pontus; Lien, Egil (Journal article, 2017)
      Innate immunity is critical for host defenses against pathogens, but many bacteria display complex ways of interacting with innate immune signaling, as they may both activate and evade certain pathways. Gram‐negative ...

    • Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation 

      Lentini, Germana; Famà, Agata; De Gaetano, Giuseppe Valerio; Coppolino, Francesco; Mahjoub, Ahlem Khachroub; Ryan, Liv; Lien, Egil; Espevik, Terje; Beninati, Concetta; Teti, Giuseppe (Peer reviewed; Journal article, 2023)
      During differentiation, neutrophils undergo a spontaneous pro-inflammatory program that is hypothesized here to be under caspase-8 control. In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk is ...

    • Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling 

      Shahini, Negar; Schjalm, Camilla; Nilsson, Per; Holt, Margrethe Flesvig; Øgaard, Jonas; Lien, Egil; Ahmed, Muhammad Shakil; Attramadal, Håvard; Aukrust, Pål; Yndestad, Arne; Mollnes, Tom Eirik; Louwe, Mieke C. (Peer reviewed; Journal article, 2020)
      Inflammation is centrally involved in the development of cardiac hypertrophy and the processes of remodelling. The complement system and Toll-like receptor (TLR) family, two upstream arms of the innate immune system, have ...

    • Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis 

      Torp, May-Kristin; Ranheim, Trine; Schjalm, Camilla; Hjorth, Marit; Heiestad, Christina Mathisen; Dalen, Knut Tomas; Nilsson, Per; Mollnes, Tom Eirik; Pischke, Soeren; Lien, Egil; Vaage, Ingvar Jarle; Yndestad, Arne; Stensløkken, Kåre-Olav (Peer reviewed; Journal article, 2022)
      The innate immune system is rapidly activated during myocardial infarction and blockade of extracellular complement system reduces infarct size. Intracellular complement, however, appears to be closely linked to metabolic ...

    • MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection 

      Lei, Xuqiu; Chen, Yongzhi; Lien, Egil; Fitzgerald, Katherine A. (Journal article; Peer reviewed, 2023)
      Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells. All three pathways share ...

    • NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity 

      Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine; Yndestad, Arne (Journal article; Peer reviewed, 2019)
      Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ...

    • Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo 

      Nilsen, Kaja Elisabeth; Zhang, Boyao; Skjesol, Astrid; Ryan, Liv; Vagle, Hilde; Bøe, Maren Helene; Orning, Pontus; Kim, Hera; Bakke, Siril Skaret; Elamurugan, Kirusika; Mestvedt, Ingvild Bergdal; Stenvik, Jørgen; Husebye, Harald; Lien, Egil; Espevik, Terje; Yurchenko, Mariya (Peer reviewed; Journal article, 2023)
      Inflammation plays a crucial role in the development and progression of many diseases, and is often caused by dysregulation of signalling from pattern recognition receptors, such as TLRs. Inhibition of key protein–protein ...

    • RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis 

      Zelic, Matija; Pontarelli, Fabrizio; Woodworth, Lisa; Zhu, Cheng; Mahan, Amy; Ren, Yi; LaMorte, Michael; Gruber, Ross; Keane, Aislinn; Loring, Pequita; Guo, Lilu; Xia, Tai-he; Zhang, Boyao; Ørning, Mathias Pontus; Lien, Egil; Degterev, Alexei; Hammond, Timothy; Ofengeim, Dimitry (Peer reviewed; Journal article, 2021)

    • Streptolysin O Induces the Ubiquitination and Degradation of Pro-IL-1β 

      Hancz, Dora; Westerlund, Elsa; Valfridsson, Christine; Aemero, Getachew Melkamu; Bastiat-Sempe, Benedicte; Ørning, Mathias Pontus; Lien, Egil; Wessels, Michael; Persson, Jenny (Journal article; Peer reviewed, 2019)
      Group A Streptococcus (GAS) is a common and versatile human pathogen causing a variety of diseases. One of the many virulence factors of GAS is the secreted pore-forming cytotoxin streptolysin O (SLO), which has been ...

    • The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation 

      Ratner, Dmitry; Ørning, Mathias Pontus; Proulx, MK; Wang, Donghai; Gavrilin, Mikhail; Wewers, Mark; Alnemri, Emad; Johnson, Peter; Lee, Bettina; Mecsas, Joan; Kayagaki, Nobuhiko; Goguen, JD; Lien, Egil (Journal article; Peer reviewed, 2016)
      Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses ...