Blar i NTNU Open på forfatter "Lian, Aina-Mari"
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Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts
Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2021)Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ... -
Targeting a therapeutically relevant concentration of alendronate for in vitro studies on osteoblasts
Krüger, Tormod Bjartveit; Syversen, Unni; Herlofson, Bente Brokstad; Lian, Aina-Mari; Reseland, Janne Elin (Peer reviewed; Journal article, 2022)Objective Bisphosphonates like alendronate mainly exert their effects on osteoclasts. However, osteoblasts are also affected, but exposed to a much lower concentration in vivo than the osteoclasts. Given that the effects ... -
Vitamin K2 modulates vitamin D induced mechanical properties of human 3D bone spheroids in vitro
Schröder, Maria; Riksen, Elisabeth Aurstad; He, Jianying; Skallerud, Bjørn Helge; Møller, Mona Elisabeth; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2020)Rotational culture promotes primary human osteoblasts (hOBs) to form three-dimensional (3D) multicellular spheroids with bone tissue-like structure without any scaffolding material. Cell-based bone models enable us to ...