• Circulating markers of cellular immune activation in pre-diagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3) 

      Huang, Joyce Yongxu; Larose, Tricia L; Luu, Hung N; Wang, Renwei; Fanidi, Anouar; Alcala, Karine; Stevens, Victoria L.; Weinstein, Stephanie J.; Albanes, Demetrius; Caporaso, Neil E.; Purdue, Mark P.; Ziegler, Regina G.; Freedman, Neal D.; Lan, Qing; Prentice, Ross L.; Pettinger, Mary; Thomson, Cynthia A.; Cai, Qiuyin; Wu, Jie; Blot, William J.; Shu, Xiao-Ou; Zheng, Wei; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loïc; Wilkens, Lynn R; Haiman, Christopher A.; Zhang, Xuehong; Stampfer, Meir J.; Han, Jiali; Giles, Graham G.; Hodge, Allison M.; Severi, Gianluca; Johansson, Mikael; Grankvist, Kjell; Langhammer, Arnulf; Hveem, Kristian; Xiang, Yong-Bing; Li, Hong-Lan; Gao, Yu-Tang; Visvanathan, Kala; Ueland, Per Magne; Midttun, Øivind; Ulvik, Arve; Buring, Julie E.; Lee, I-Min; Sesso, Howard D.; Gaziano, J. Michael; Manjer, Jonas; Relton, Caroline; Koh, Woon-Puay; Brennan, Paul; Johansson, Mattias; Yuan, Jian-Min (Journal article; Peer reviewed, 2019)
      Cell‐mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) ...
    • Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men 

      Watts, Eleanor L.; Appleby, Paul N.; Albanes, Demetrius; Black, Amanda; Chan, June M.; Chen, Chu; Cirillo, Piera M.; Cohn, Barbara A.; Cook, Michael B.; Donovan, Jenny L.; Ferrucci, Luigi; Garland, Cedric F.; Giles, Graham G.; Goodman, Phyllis J.; Habel, Laurel A.; Haiman, Christopher A.; Holly, Jeff M.P.; Hoover, Robert N.; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurence N.; Kubo, Tatsuhiko; Le Marchand, Loïc; Luostarinen, Tapio; MacInnis, Robert J.; Mäenpää, Hanna O.; Männistö, Satu; Metter, E. Jeffrey; Milne, Roger L.; Nomura, Abraham M.Y.; Oliver, Steven E.; Parsons, J. Kellogg; Peeters, Petra H.; Platz, Elizabeth A.; Riboli, Elio; Ricceri, Fulvio; Rinaldi, Sabina; Rissanen, Harri; Sawada, Norie; Schaefer, Catherine A.; Schenk, Jeannette M.; Stanczyk, Frank Z.; Stampfer, Meir; Stattin, Pär; Stenman, Ulf-Håkan; Tjønneland, Anne; Trichopoulou, Antonia; Thompson, Ian M.; Tsugane, Shoichiro; Vatten, Lars Johan; Whittemore, Alice S.; Ziegler, Regina G.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Peer reviewed, 2017)
      Introduction Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the ...
    • A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium 

      Midttun, Øivind; Ulvik, Arve; Meyer, Klaus; Zahed, Hana; Giles, Graham G.; Manjer, Jonas; Sandsveden, Malte; Langhammer, Arnulf; Sørgjerd, Elin Pettersen; Behndig, Annelie F.; Johansson, Mikael; Freedman, Neal D.; Huang, Wen-Yi; Chen, Chu; Prentice, Ross; Stevens, Victoria L.; Wang, Ying; Le Marchand, Loïc; Weinstein, Stephanie J.; Cai, Qiuyin; Arslan, Alan A.; Chen, Yu; Shu, Xiao-Ou; Zheng, Wei; Yuan, Jian-Min; Koh, Woon-Puay; Visvanathan, Kala; Sesso, Howard D.; Zhang, Xuehong; Gaziano, J. Michael; Fanidi, Anouar; Robbins, Hilary A.; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Peer reviewed; Journal article, 2023)
      Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ). Neopterin ...
    • Low free testosterone and prostate cancer risk: A collaborative analysis of 20 prospective studies 

      Watts, Eleanor L.; Appleby, Paul N.; Perez-Cornago, Aurora; Bueno-De-Mesquita, Hendrik Bastiaan; Chan, June M.; Chen, Chu; Cohn, Barbara A.; Cook, Michael B.; Flicker, Leon; Freedman, Neal D.; Giles, Graham G.; Giovannucci, Edward; Gislefoss, Randi Elin; Hankey, Graeme J.; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurence N.; Kubo, Tatsuhiko; Le Marchand, Loïc; Luben, Robert N.; Luostarinen, Tapio; Männistö, Satu; Metter, E. Jeffrey; Mikami, Kazuya; Milne, Roger L.; Ozasa, Kotaro; Platz, Elizabeth A.; Quirós, José Ramón; Rissanen, Harri; Sawada, Norie; Stampfer, Meir; Stanczyk, Frank Z.; Stattin, Pär; Tamakoshi, Akiko; Tangen, Catherine M.; Thompson, Ian M.; Tsilidis, Konstantinos K.; Tsugane, Shoichiro; Ursin, Giske; Vatten, Lars Johan; Weiss, Noel S.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Peer reviewed, 2018)
      Background Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in ...
    • No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3) 

      Muller, David C.; Hodge, Allison M.; Fanidi, Anouar; Albanes, Demetrius; Mai, Xiao-Mei; Shu, Xiao Ou; Weinstein, Stephanie J.; Larose, Tricia L; Zhang, Xuehong; Han, Jingquan; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Ma, Jing; Gaziano, John Michael; Sesso, Howard D.; Stevens, Victoria L.; McCullough, Marjorie L.; Layne, Tracy M.; Prentice, Ross; Pettinger, Mary; Thomson, Cynthia A.; Zheng, Wei; Gao, Yutang; Rothman, Nathaniel; Xiang, Yong-Bing; Cai, Hui; Wang, Rui; Yuan, Jian-Min; Koh, Woon-Puay; Butler, Lesley M.; Cai, Qiuyin; Blot, William James; Wu, Jie; Ueland, Per Magne; Midttun, Øivind; Langhammer, Arnulf; Hveem, Kristian; Johansson, Mikael B.; Hultdin, Johan; Grankvist, Kjell; Arslan, Alan A.; Le Marchand, Loïc; Severi, Gianluca; Johansson, Mattias; Brennan, Paul (Journal article; Peer reviewed, 2018)
      Background There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in ...