Browsing NTNU Open by Author "Lappegård, Knut Tore"
Now showing items 1-9 of 9
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Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Hovland, Anders; Retterstøl, Kjetil; Mollnes, Tom Eirik; Halvorsen, Bente Evy; Aukrust, Pål; Lappegård, Knut Tore (Peer reviewed; Journal article, 2020)Objectives. Inflammatory responses are closely knit with low-density lipoprotein (LDL)-cholesterol in driving atherosclerosis. Even if LDL-cholesterol is causative to atherosclerotic diseases and LDL-cholesterol lowering ... -
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
Lau, Corinna; Nygård, Ståle; Fure, Hilde; Olstad, Ole Kristoffer; Holden, Marit; Lappegård, Knut Tore; Brekke, Ole Lars; Espevik, Terje; Hovig, Johannes Eivind; Mollnes, Tom Eirik (Journal article, 2015)Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by ... -
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
Landsem, Anne; Fure, Hilde; Ludviksen, Judith K; Christiansen, Dorte; Lau, Corinna; Mathisen, Monica Dammen; Bergseth, Grete; Nymo, Stig Haugset; Lappegård, Knut Tore; Woodruff, T. M.; Espevik, Terje; Mollnes, Tom Eirik; Brekke, Ole-Lars (Journal article; Peer reviewed, 2018)There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully ... -
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
Lau, Corinna; Olstad, Ole Kristoffer; Holden, Marit; Nygård, Ståle; Fure, Hilde; Lappegård, Knut Tore; Brekke, Ole Lars; Espevik, Terje; Hovig, Johannes Eivind; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2015)Non-sterile pathogen-induced sepsis and sterile inflammation like in trauma or ischemia–reperfusion injury may both coincide with the life threatening systemic inflammatory response syndrome and multi-organ failure. ... -
Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5‐deficient individual
Hardersen, Randolf Inge; Enebakk, Terje; Christiansen, Dorte; Bergseth, Grete; Brekke, Ole-Lars; Mollnes, Tom Eirik; Lappegård, Knut Tore; Hovland, Anders (Journal article, 2018)The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5‐deficient (C5D) individual, comparing it to C5‐deficient blood reconstituted ... -
Hands-free continuous carotid Doppler ultrasound for detection of the pulse during cardiac arrest in a porcine model
Faldaas, Bjørn Ove; Nielsen, Erik Waage; Storm, Benjamin; Lappegård, Knut Tore; How, Ole-Jakob; Nilsen, Bent Aksel; Kiss, Gabriel Hanssen; Skogvoll, Eirik; Torp, Hans; Ingul, Charlotte Ingeborg Björk (Peer reviewed; Journal article, 2023)Background/Purpose Pulse palpation is an unreliable method for diagnosing cardiac arrest. To address this limitation, continuous hemodynamic monitoring may be a viable solution. Therefore, we developed a novel, hands-free ... -
High-density lipoprotein subfractions: Much ado about nothing or clinically important?
Lappegård, Knut Tore; Kjellmo, Christian Abendstein; Hovland, Anders (Peer reviewed; Journal article, 2021)High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with ... -
Real-time feedback on chest compression efficacy by hands-free carotid Doppler in a porcine model
Faldaas, Bjørn Ove; Nielsen, Erik Waage; Storm, Benjamin Stage; Lappegård, Knut Tore; Nilsen, Bent Aksel; Kiss, Gabriel Hanssen; Skogvoll, Eirik; Torp, Hans; Ingul, Charlotte Ingeborg Björk (Journal article; Peer reviewed, 2024)Aim: Current guidelines for cardiopulmonary resuscitation (CPR) recommend a one-size-fits-all approach in relation to the positioning of chest compressions. We recently developed RescueDoppler, a hands-free Doppler ultrasound ... -
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
Hovland, Anders; Jonasson, Lena; Garred, Peter; Yndestad, Arne; Aukrust, Pål; Lappegård, Knut Tore; Espevik, Terje; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2015)Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier ...