Browsing NTNU Open by Author "Langaas, Mette"
Now showing items 1-20 of 71
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A Semi-Supervised Approach to the Application of Sensor-based ChangePoint Detection for Failure Prediction in Industrial Instruments
Kazemi, Amirhossein (Master thesis, 2019)I dette prosjektet analyserer vi muligheten til å anvende statistiske metoder for change-pointdeteksjon for å oppdage anomaliteter som forårsaker feil i industrielle instrumenter. I tillegg gir vi en oversikt over ulike ... -
A statistical simulation-based framework for sample size considerations in case-control SNP association studies
Edsberg, Erik (Master thesis, 2008)In the thesis, a statistical simulation-based framework is presented that is intended for making sample size and power considerations prior to case-control association studies. It reviews biological background and biallelic ... -
Adhd and mental health symptoms in the identification of young adults with increased risk of alcohol dependency in the general population—the hunt4 population study
Lauvsnes, Anders Dahlen Forsmo; Langaas, Mette; Olsen, Alexander; Vassileva, Jasmin; Spigset, Olav; Gråwe, Rolf Wilhelm (Peer reviewed; Journal article, 2021)Symptoms of ADHD are strongly associated with alcohol use disorders, and mental health symptoms attenuate this relationship. There is limited knowledge about how specific symptoms of inattentiveness and hyperactivity/impulsivity ... -
Analysis of commom cause failures in complex safety instrumented systems
Lilleheier, Torbjørn (Master thesis, 2008)Common cause failures (CCFs) have been an important issue in reliability analysis for several decades, especially when dealing with safety instrumented systems (SIS). Different approaches have been used in order to describe ... -
Applied statistical methods and network analysis for identifying similarities and differences in biological data for various traits.
Hall, Martina (Doctoral theses at NTNU;2024:421, Doctoral thesis, 2024)"Observing differences in various traits, such as differences in human height, why some people are more susceptible to certain diseases, or why some species survive in certain environments, we often question why and how ... -
Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study
Bjørnland, Thea; Langaas, Mette; Mostad, Ingrid Løvold; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2017)Background Our aim was to assess the influence of age, gender and lifestyle factors on the effect of the obesity-promoting alleles of FTO and MCR4. Methods The HUNT study comprises health information on the ... -
Associations between the FTO rs9939609 genotypes and insulin sensitivity, glucose tolerance, energy metabolism, appetite hormones, and diet in patients with severe obesity
de Soysa, Ann Kristin Hjelle (Doctoral theses at NTNU;2022:398, Doctoral thesis, 2022) -
Bruk av digitale øvinger i grunnutdanningen i matematikk
Rønning, Frode; Buan, Aslak Bakke; Langaas, Mette; Thaule, Marius (Journal article; Peer reviewed, 2017)Siden høsten 2013 har det vært gjort betydelige endringer i strukturen på grunnemnene i matematikk og statistikk ved NTNU, fra januar 2014 innenfor rammene av prosjektet KTDiM (Kvalitet, tilgjengelighet og differensiering ... -
Changepoint model selection in Gaussian data by maximization of approximate Bayes Factors with the Pruned Exact Linear Time algorithm
Bakka, Kristin Benedicte (Master thesis, 2018)In this thesis we consider the changepoint detection in independently distributed Gaussian data. Detection of multiple changepoints in a data set is treated as a model selection problem where the model complexity is ... -
Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT study.
Velle-Forbord, Torbjørn; Eidlaug, Maria; Debik, Julia Barbara; Sæther, Julie Caroline; Follestad, Turid; Nauman, Javaid; Gigante, Bruna; Røsjø, Helge; Omland, Torbjørn; Langaas, Mette; Bye, Anja (Peer reviewed; Journal article, 2019)Background and aims Several risk prediction models for coronary heart disease (CHD) are available today, however, they only explain a modest proportion of the incidence. Circulating microRNAs (miRs) have recently been ... -
Combining the MAX test with methods for Family-wise error rate
Risberg, Marita (Master thesis, 2008)In chapter 1 the necessary biological background for this thesis is provided. Here the definition of a SNP is provided and the connection between the human genom, DNA and SNPs. Chapter 2 gives the notation and definitions ... -
Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models
Halle, Kari Krizak; Bakke, Øyvind; Djurovic, Srdjan; Bye, Anja; Ryeng, Einar; Wisløff, Ulrik; Andreassen, Ole Andreas; Langaas, Mette (Peer reviewed; Journal article, 2020)In genetic association studies, detecting phenotype–genotype association is a primary goal. We assume that the relationship between the data—phenotype, genetic markers and environmental covariates—can be modeled by a ... -
Detecting Neuronal Activity with Lasso Penalized Logistic Regression
Kristiansen, Dag Johnsrud (Master thesis, 2019)Hjernen er det mest komplekse organet i dyr, der det kontinuerlig overføres signaler mellom dens cellulære komponenter. Vi vil i denne oppgaven undersøke hvordan slik informasjon flyter, og prøve å fastslå enkelte koblinger. ... -
Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age
Lian, Ingrid Alsos; Langaas, Mette; Moses, Eric; Johansson, Åsa (Journal article; Peer reviewed, 2013)Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational ... -
Estimating Time-Continuous Gene Expression Profiles Using the Linear Mixed Effects Framework
Page, Christian Magnus (Master thesis, 2012)With the first generation of microarray experiments there were discussions and important arguments on how the samples should be treated. This included what kind of transformation and normalization procedures that the data ... -
Explainability and validity of statistical methods for genome-wide association studies: Extending Shapley-based explanation methods and adapting saddlepoint approximations
Johnsen, Pål Vegard (Doctoral theses at NTNU;2022:26, Doctoral thesis, 2022) -
Explaining random forest predictions with partial dependence and accumulated local effects plots
Henninen, Rasmus Hilmer (Bachelor thesis, 2021)Denne bacheloroppgaven tar for seg potensielle bruskområder for to XAI metoder for å analysere svart boks modeller. For å gjøre dette brukes en svart boks model fra statistisk læring, for denne oppgaven er det valgt å bruke ... -
Exploring Dietary Intake in Adults with Severe Obesity and Associations with the FTO rs9939609 Genotypes
De Soysa, Ann Kristin Hjelle; Alho Letra Martins, Catia Patricia; Langaas, Mette; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Peer reviewed; Journal article, 2023)Background Few have studied the associations between rs9939609 genotypes in the obesity candidate locus FTO and energy and nutrient intakes and meal frequencies in adults with severe obesity. We are unaware of studies ... -
Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study
Nordeidet, Ada Nilsen; Klevjer, Marie; Wisløff, Ulrik; Langaas, Mette; Bye, Anja (Journal article; Peer reviewed, 2023)Low cardiorespiratory fitness, measured as maximal oxygen uptake (V̇o2max), is associated with all-cause mortality and disease-specific morbidity and mortality and is estimated to have a large genetic component (∼60%). ... -
The fat mass and obesity-associated (FTO) gene allele rs9939609 and glucose tolerance, hepatic and total insulin sensitivity, in adults with obesity
De Soysa, Ann Kristin Hjelle; Langaas, Mette; Jakic, Anida; Shojaee-Moradie, Fariba; Umpleby, A. Margot; Grill, Valdemar Erik Robert; Mostad, Ingrid Løvold (Peer reviewed; Journal article, 2021)The objective of the study was to assess associations of the rs9939609 FTO allele to glucose tolerance, hepatic and total insulin sensitivity (IS) in individuals with obesity. From a low-dose hyperinsulinemic euglycemic ...