Browsing NTNU Open by Author "Kobro-Flatmoen, Asgeir"
Now showing items 1-19 of 19
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Are the Neuroprotective Effects of Exercise Training Systemically Mediated?
Tari, Atefe R; Norevik, Cecilie Skarstad; Scrimgeour, Nathan Robert; Kobro-Flatmoen, Asgeir; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Wrann, Christiane D; Selbæk, Geir; Kivipelt, Miia; Moreira, Jose Bianco Nascimento; Wisloff, Ulrik (Journal article; Peer reviewed, 2019)To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate ... -
Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons
Omholt, Stig William; Lejneva, Raissa; Donate Lagartos, Maria Jose; Caponio, Domenica; Fang, Fei; Kobro-Flatmoen, Asgeir (Journal article; Peer reviewed, 2024)In layer II of the entorhinal cortex, the principal neurons that project to the dentate gyrus and the CA3/2 hippocampal fields markedly express the large glycoprotein reelin (Re + ECLII neurons). In rodents, neurons located ... -
Can exercise training teach us how to treat Alzheimer's disease?
Huuha, Aleksi Matias; Norevik, Cecilie Skarstad; Moreira, Jose Bianco Nascimento; Kobro-Flatmoen, Asgeir; Scrimgeour, Nathan Robert; Kivipelto, Miia; Van Praag, Henriette; Ziaei, Maryam; Sando, Sigrid Botne; Wisløff, Ulrik; Tari, Atefe R (Peer reviewed; Journal article, 2022)Alzheimer’s disease (AD) is the most common cause of dementia and there is currently no cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence and costs of dementia are needed. Physical ... -
Comparative Contemplations on the Hippocampus
Witter, Menno; Kleven, Heidi; Kobro-Flatmoen, Asgeir (Journal article; Peer reviewed, 2017)The hippocampus in mammals is a morphologically well-defined structure, and so are its main subdivisions. To define the homologous structure in other vertebrate clades, using these morphological criteria has been difficult, ... -
Dissecting the complexities of Alzheimer's disease: Engineering selectively vulnerable neural networks in vitro
Hanssen, Katrine Sjaastad (Doctoral theses at NTNU;2023:365, Doctoral thesis, 2023)Alzheimer’s disease (AD) is a progressive, neurodegenerative disease where accumulation of neuropathology can start up to two decades before symptom onset. With no cure for the disease, relevant models of AD are needed to ... -
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
Hanssen, Katrine Sjaastad; Witter, Menno Peter; Sandvig, Axel; Sandvig, Ioanna; Kobro-Flatmoen, Asgeir (Peer reviewed; Journal article, 2023)Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part ... -
Effects on Tau Hyperphosphorylation as a Function of Lowering Levels of Reelin in Entorhinal Cortex Layer II Neurons
Lund, Tore Bryntesen (Master thesis, 2020)Alzheimers sykdom er en progressiv, og dødelig nevrodegenerativ sykdom, karakterisert av de nevropatpologiske kjennetegne amyloid-β plakk og nevrofibrillære floker. Det har blitt estimert at de patologiske celleforandringene ... -
Entorhinal cell-specific changes as an initial cause of Alzheimer's disease
Kobro-Flatmoen, Asgeir (Doctoral theses at NTNU;2017:74, Doctoral thesis, 2017)Evidence shows that Alzheimer’s disease (AD) begins with subtle and anatomically restricted pathological changes within the brain, ultimately leading to widespread neuronal loss and dementia. While high numbers of ... -
Establishing lateral entorhinal cortex layer II-neuron cultures as a tool for the investigation of early Alzheimer's disease related changes
Hanssen, Katrine Sjaastad (Master thesis, 2019)Alzheimer’s disease is a slowly progressing and ultimately fatal neurodegenerative disease affecting more than 46 million people worldwide in 2018. The entorhinal cortex (EC), in particular the layer II of the domains ... -
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain
Norevik, Cecilie Skarstad; Huuha, Aleksi Matias; Røsbjørgen, Ragnhild; Bergersen, Linda Hildegard; Jacobsen, Kamilla; Miguel dos Santos, Rodrigo; Ryan, Liv; Skender, Belma; Bianco Nascimento Moreira, Jose; Kobro-Flatmoen, Asgeir; Witter, Menno Peter; Scrimgeour, Nathan Robert; Rafiee Tari, Atefe (Peer reviewed; Journal article, 2023)Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ... -
Extraction and culturing of adult hippocampal and entorhinal neurons from Alzheimer model-animals
Niethammer, Salome Nora (Master thesis, 2022)Abstract will be available on 2027-12-31 -
Intracellular Amyloid Beta in the Normal Rodent Brain
Hormann, Thea Meier (Master thesis, 2021) -
Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer's Disease
Kobro-Flatmoen, Asgeir; Hormann, Thea Meier; Gouras, Gunnar (Journal article; Peer reviewed, 2023) -
Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β
Kobro-Flatmoen, Asgeir; Battistin, Claudia; Raveendran Nair, Rajeevkumar; Bjorkli, Christiana; Skender, Belma; Kentros, Clifford George; Gouras, Gunnar; Witter, Menno Peter (Peer reviewed; Journal article, 2023)Projection neurons in the anteriolateral part of entorhinal cortex layer II are the predominant cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in prodromal Alzheimer’s disease. A ... -
Neuronal chemo‐architecture of the entorhinal cortex: A comparative review
Kobro-Flatmoen, Asgeir; Witter, Menno (Journal article; Peer reviewed, 2019)The identification of neuronal markers, that is, molecules selectively present in subsets of neurons, contributes to our understanding of brain areas and the networks within them. Specifically, recognizing the distribution ... -
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis
Roos, Tomas T; Garcia, Megg G; Martinsson, Isak; Mabrouk, Rana; Israelsson, Bodil; Deierborg, Tomas; Kobro-Flatmoen, Asgeir; Tanila, Heikki; Gouras, Gunnar K (Peer reviewed; Journal article, 2021)The amyloid-beta peptide (Aβ) is thought to have prion-like properties promoting its spread throughout the brain in Alzheimer's disease (AD). However, the cellular mechanism(s) of this spread remains unclear. Here, we show ... -
Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy
Kobro-Flatmoen, Asgeir; Lagartos-Donate, Maria Jose; Aman, Yahyah; Edison, Paul; Witter, Menno; Fang, Fei (Peer reviewed; Journal article, 2021)The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex (EC) is a pivotal ... -
Structural connectivity-based segmentation of the human entorhinal cortex
Syversen, Ingrid Framås; Witter, Menno P.; Kobro-Flatmoen, Asgeir; Goa, Pål Erik; Schröder, Tobias Navarro; Doeller, Christian F. (Peer reviewed; Journal article, 2021)The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic ... -
Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT)
Tari, Atefe R; Selbæk, Geir; Franklin, Barry A.; Bergh, Sverre; Skjellegrind, Håvard; Sallis, Robert E.; Bosnes, Ingunn; Stordal, Eystein; Ziaei, Maryam; Lydersen, Stian; Kobro-Flatmoen, Asgeir; Huuha, Aleksi Matias; Nauman, Javaid; Wisløff, Ulrik (Peer reviewed; Journal article, 2022)Background The Personal Activity Intelligence (PAI) translates heart rate during daily activity into a weekly score. Obtaining a weekly PAI score ≥100 is associated with reduced risk of premature morbidity and mortality ...