• Are the Neuroprotective Effects of Exercise Training Systemically Mediated? 

      Tari, Atefe R; Norevik, Cecilie Skarstad; Scrimgeour, Nathan Robert; Kobro-Flatmoen, Asgeir; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Wrann, Christiane D; Selbæk, Geir; Kivipelt, Miia; Moreira, Jose Bianco Nascimento; Wisloff, Ulrik (Journal article; Peer reviewed, 2019)
      To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate ...
    • Comparative Contemplations on the Hippocampus 

      Witter, Menno; Kleven, Heidi; Kobro-Flatmoen, Asgeir (Journal article; Peer reviewed, 2017)
      The hippocampus in mammals is a morphologically well-defined structure, and so are its main subdivisions. To define the homologous structure in other vertebrate clades, using these morphological criteria has been difficult, ...
    • Effects on Tau Hyperphosphorylation as a Function of Lowering Levels of Reelin in Entorhinal Cortex Layer II Neurons 

      Lund, Tore Bryntesen (Master thesis, 2020)
      Alzheimers sykdom er en progressiv, og dødelig nevrodegenerativ sykdom, karakterisert av de nevropatpologiske kjennetegne amyloid-β plakk og nevrofibrillære floker. Det har blitt estimert at de patologiske celleforandringene ...
    • Entorhinal cell-specific changes as an initial cause of Alzheimer's disease 

      Kobro-Flatmoen, Asgeir (Doctoral theses at NTNU;2017:74, Doctoral thesis, 2017)
      Evidence shows that Alzheimer’s disease (AD) begins with subtle and anatomically restricted pathological changes within the brain, ultimately leading to widespread neuronal loss and dementia. While high numbers of ...
    • Establishing lateral entorhinal cortex layer II-neuron cultures as a tool for the investigation of early Alzheimer's disease related changes 

      Hanssen, Katrine Sjaastad (Master thesis, 2019)
      Alzheimer’s disease is a slowly progressing and ultimately fatal neurodegenerative disease affecting more than 46 million people worldwide in 2018. The entorhinal cortex (EC), in particular the layer II of the domains ...
    • Intracellular Amyloid Beta in the Normal Rodent Brain 

      Hormann, Thea Meier (Master thesis, 2021)
      Amyloid beta (Aβ) er et av kjennetegnene ved Alzheimers sykdom (AD) og er et fragment fra et større protein kalt amyloid forløperprotein (APP). Aβ har tradisjonelt blitt ansett som å kun finnes ekstracellulært som amyloid ...
    • Neuronal chemo‐architecture of the entorhinal cortex: A comparative review 

      Kobro-Flatmoen, Asgeir; Witter, Menno (Journal article; Peer reviewed, 2019)
      The identification of neuronal markers, that is, molecules selectively present in subsets of neurons, contributes to our understanding of brain areas and the networks within them. Specifically, recognizing the distribution ...
    • Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis 

      Roos, Tomas T; Garcia, Megg G; Martinsson, Isak; Mabrouk, Rana; Israelsson, Bodil; Deierborg, Tomas; Kobro-Flatmoen, Asgeir; Tanila, Heikki; Gouras, Gunnar K (Peer reviewed; Journal article, 2021)
      The amyloid-beta peptide (Aβ) is thought to have prion-like properties promoting its spread throughout the brain in Alzheimer's disease (AD). However, the cellular mechanism(s) of this spread remains unclear. Here, we show ...
    • Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy 

      Kobro-Flatmoen, Asgeir; Lagartos-Donate, Maria Jose; Aman, Yahyah; Edison, Paul; Witter, Menno; Fang, Fei (Peer reviewed; Journal article, 2021)
      The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex (EC) is a pivotal ...
    • Structural connectivity-based segmentation of the human entorhinal cortex 

      Syversen, Ingrid Framås; Witter, Menno P.; Kobro-Flatmoen, Asgeir; Goa, Pål Erik; Schröder, Tobias Navarro; Doeller, Christian F. (Peer reviewed; Journal article, 2021)
      The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic ...