• Adaptive computerized working memory training in patients with mild cognitive impairment. A randomized double-blind active controlled trial 

      Flak, Marianne Møretrø; Hol, Haakon Ramsland; Hernes, Susanne M S; Chang, Linda; Engvig, Andreas; Bjuland, Knut Jørgen; Pripp, Are Hugo; Madsen, Bengt-Ove; Knapskog, Anne Brita; Ulstein, Ingun; Lona, Trine Eli.B.; Skranes, Jon Sverre; Løhaugen, Gro (Journal article; Peer reviewed, 2019)
      Objective: We investigated if a 5-week computerized adaptive working memory training program (Cogmed®) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions ...
    • The ANeED study – ambroxol in new and early dementia with Lewy bodies (DLB): protocol for a phase IIa multicentre, randomised, double-blinded and placebo-controlled trial 

      Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Kirsebom, Bjørn-Eivind; Selnes, Per; Fløvig, John Christian Jøraholmen; Knapskog, Anne Brita; Skogseth, Ragnhild Eide; Hubbers, Jessica; Holst-Larsen, Elin; Rongve, Arvid (Peer reviewed; Journal article, 2023)
      Background: Currently, there are no disease-modifying pharmacological treatment options for dementia with Lewy bodies (DLB). The hallmark of DLB is pathological alpha-synuclein (aS) deposition. There are growing amounts ...
    • Association between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinics 

      Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Barca, Maria Lage; Knapskog, Anne Brita; Cavallin, Lena; Engedal, Knut; Skovlund, Eva; Saltvedt, Ingvild; Selbaek, Geir (Journal article; Peer reviewed, 2018)
      Background: Vascular risk factors increase the risk of Alzheimer’s disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of this ...
    • Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease 

      Henjum, Kristi; Watne, Leiv; Godang, Kristin; Halaas, Nathalie Bodd; Eldholm, Rannveig Sakshaug; Blennow, Kaj; Zetterberg, Henrik; Saltvedt, Ingvild; Bollerslev, Jens; Knapskog, Anne Brita (Journal article; Peer reviewed, 2022)
      Noradrenergic and dopaminergic neurons are involved in cognitive functions, relate to behavioral and psychological symptoms in dementia and are affected in Alzheimer’s disease (AD). Amyloid plaques (A), neurofibrillary ...
    • Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification 

      Knapskog, Anne Brita; Henjum, Kristi; Idland, Ane-Victoria; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Saltvedt, Ingvild; Watne, Leiv; Engedal, Knut; Nilsson, Lars N.G. (Peer reviewed; Journal article, 2020)
      Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia. Its cleaved fragments, soluble TREM2 (sTREM2), can be measured in the cerebrospinal fluid (CSF). Previous studies ...
    • Cognitive Profiles and Atrophy Ratings on MRI in Senior Patients With Mild Cognitive Impairment 

      Flak, Marianne Møretrø; Hol, Haakon Ramsland; Hernes, Susanne M S; Chang, Linda; Ernst, Thomas; Engvig, Andreas; Bjuland, Knut Jørgen; Madsen, Bengt-Ove; Lindland, Elisabeth Margrete Stokke; Knapskog, Anne Brita; Ulstein, Ingun; Lona, Trine Eli.B.; Skranes, Jon Sverre; Løhaugen, Gro (Journal article; Peer reviewed, 2018)
      In this cross-sectional study, we sought to describe cognitive and neuroimaging profiles of Memory clinic patients with Mild Cognitive Impairment (MCI). 51 MCI patients and 51 controls, matched on age, sex, and socio-economic ...
    • Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) - a national research and quality registry with a biomaterial collection 

      Medbøen, Ingrid Tøndel; Persson, Karin Ester Torun; Nåvik, Marit; Totland, Torunn Holm; Bergh, Sverre; Treviño, Cathrine Selnes; Ulstein, Ingun; Engedal, Knut; Knapskog, Anne Brita; Brækhus, Anne; Øksengård, Anne Rita; Horndalsveen, Peter Otto; Saltvedt, Ingvild; Lyngroth, Anne Liv; Ranhoff, Anette Hylen; Skrettingland, Dagny B; Naik, Mala; Soares, Jelena Zugic; Johnsen, Bente; Selbæk, Geir (Peer reviewed; Journal article, 2022)
      Purpose The Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) was established to harmonise and improve the quality of diagnostic practice across clinics assessing persons with cognitive symptoms in ...
    • Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients 

      Knapskog, Anne Brita; Eldholm, Rannveig Sakshaug; Brækhus, Anne; Engedal, Knut; Saltvedt, Ingvild (Journal article; Peer reviewed, 2017)
      Background The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ), phospho tau (P-tau) and total tau (T-tau) are used increasingly to support a clinical diagnosis of Alzheimer’s disease. The diagnostic power of these ...
    • Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers 

      Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Athanasiu, Lavinia; Bahrami, Shahram; Bergh, Sverre; Djurovic, Srdjan; Fladby, Tormod; Jarholm, Jonas Alexander; Knapskog, Anne Brita; Pålhaugen, Lene; Saltvedt, Ingvild; Selbæk, Geir; Selnes, Per; Andreassen, Ole; Shadrin, Alexey; Skoog, Ingmar; Soininen, Hilkka; Tsolaki, Magda; Van Broeckhoven, Christine; Van Dongen, Jasper; van Swieten, John C.; Vandenberghe, Rik; Vidal, Jean-Sébastien; Visser, Pieter J.; Vogelgsang, Jonathan; Waern, Margda; Wagner, Michael; Wiltfang, Jens; Wittens, Mandy M.J.; Zetterberg, Henrik; Zulaica, Miren; van Duijn, Cornelia M.; Bjerke, Maria; Engelborghs, Sebastiaan; Jessen, Frank; Teunissen, Charlotte E.; Pastor, Pau; Hiltunen, Mikko; Ingelsson, Martin; Clarimón, Jordi; Sleegers, Kristel; Ruiz, Agustín; Ramirez, Alfredo; Cruchaga, Carlos; Lambert, Jean-Charles; van der Flier, Wiesje M. (Peer reviewed; Journal article, 2022)
      Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European ...
    • A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease 

      Edwin, Trine Holt; Henjum, Kristi; Nilsson, Lars N. G.; Watne, Leiv; Persson, Karin Ester Torun; Eldholm, Rannveig Sakshaug; Saltvedt, Ingvild; Halaas, Nathalie Bodd; Selbæk, Geir; Engedal, Knut; Strand, Bjørn Heine; Knapskog, Anne Brita (Peer reviewed; Journal article, 2020)
      Introduction: The progression rate of Alzheimer's disease (AD) varies and might be affected by the triggering receptor expressed on myeloid cells (TREM2) activity. We explored if cerebrospinal fluid (CSF) soluble TREM2 ...
    • Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease 

      Knapskog, Anne Brita; Aksnes, Mari; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Saltvedt, Ingvild Tina; Solvang, Stein-Erik Hafstad; Watne, Leiv (Peer reviewed; Journal article, 2023)
      INTRODUCTION The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a ...
    • The Impact of Classification Models, Stroke Subtype, and Vascular Risk Factors on Courses of Poststroke Cognitive Impairment 

      Aam, Stina (Doctoral theses at NTNU;2021:237, Doctoral thesis, 2021)
      Forekomsten av hjerneslag og demens øker eksponentielt med alder. Grunnet økende antall eldre i befolkningen de nærmeste årene vil denne forekomsten øke betydelig. Behandlingen av hjerneslag har bedret seg de senere årene ...
    • Impact of different methods defining post-stroke neurocognitive disorder: The Nor-COAST study 

      Munthe-Kaas, Ragnhild; Aam, Stina; Ihle-Hansen, Hege; Lydersen, Stian; Knapskog, Anne Brita; Wyller, Torgeir Bruun; Fure, Brynjar; Thingstad, Pernille; Askim, Torunn; Beyer, Mona K.; Næss, Halvor; Seljeseth, Yngve Müller; Ellekjær, Hanne; Pendlebury, Sarah T.; Saltvedt, Ingvild (Peer reviewed; Journal article, 2020)
      Introduction Post‐stroke neurocognitive disorder (NCD) is common; prevalence varies between studies, partially related to lack of consensus on how to identify cases. The aim was to compare the prevalence of post‐stroke ...
    • The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study 

      Aam, Stina; Gynnild, Mari Nordbø; Munthe-Kaas, Ragnhild; Saltvedt, Ingvild; Lydersen, Stian; Knapskog, Anne Brita; Ihle-Hansen, Hege; Ellekjær, Hanne; Eldholm, Rannveig Sakshaug; Fure, Brynjar (Peer reviewed; Journal article, 2021)
      Introduction: Post-stroke cognitive impairment (PSCI) is common, but evidence on the impact of vascular risk factors is lacking. We explored the association between pre-stroke vascular risk factors and PSCI and studied the ...
    • Is long-bout sedentary behaviour associated with long-Term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study 

      Alme, Katinka Nordheim; Knapskog, Anne Brita; Næss, Halvor; Naik, Mala; Beyer, Mona K.; Ellekjær, Hanne; English, Coralie; Ihle-Hansen, Hege; Kummeneje, Camilla S.; Munthe-Kaas, Ragnhild; Saltvedt, Ingvild; Seljeseth, Yngve Müller; Tan, Xiang chun; Thingstad, Pernille; Askim, Torunn (Peer reviewed; Journal article, 2020)
      Background and purpose Sedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, ...
    • MRI-assessed atrophy subtypes in Alzheimer’s disease and the cognitive reserve hypothesis 

      Persson, Karin; Eldholm, Rannveig Sakshaug; Barca, Maria Lage; Cavallin, Lena; Ferreira, Daniel; Knapskog, Anne Brita; Selbæk, Geir; Brækhus, Anne; Saltvedt, Ingvild; Westman, Eric; Engedal, Knut (Journal article; Peer reviewed, 2017)
      Background/Aims MRI assessment of the brain has demonstrated four different patterns of atrophy in patients with Alzheimer’s disease dementia (AD): typical AD, limbic-predominant AD, hippocampal-sparing AD, and a subtype ...
    • Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke 

      Alme, Katinka Nordheim; Ulvik, Arve; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Knapskog, Anne Brita (Peer reviewed; Journal article, 2021)
      Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation ...
    • Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study 

      Sandvig, Heidi Vihovde; Aam, Stina; Alme, Katinka Nordheim; Askim, Torunn; Beyer, Mona K.; Ellekjær, Hanne; Ihle-Hansen, Hege Beathe; Lydersen, Stian; Mollnes, Tom Eirik; Munthe-Kaas, Ragnhild; Næss, Halvor; Saltvedt, Ingvild Tina; Seljeseth, Yngve Müller; Thingstad, Anne Pernille Mæhle; Wethal, Torgeir; Knapskog, Anne Brita (Peer reviewed; Journal article, 2023)
      Background: Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers ...
    • Post-stroke Cognitive Impairment—Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study 

      Aam, Stina; Einstad, Marte Stine; Munthe-Kaas, Ragnhild; Lydersen, Stian; Ihle-Hansen, Hege; Knapskog, Anne Brita; Ellekjær, Hanne; Seljeseth, Yngve Müller; Saltvedt, Ingvild (Peer reviewed; Journal article, 2020)
      Background: Post-stroke cognitive impairment (PSCI) is common, but evidence of cognitive symptom profiles, course over time, and pathogenesis is scarce. We investigated the significance of time and etiologic stroke subtype ...
    • Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study 

      Schellhorn, Till; Zucknick, Manuela; Askim, Torunn; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege; Seljeseth, Yngve Müller; Knapskog, Anne Brita; Næss, Halvor; Ellekjær, Hanne; Thingstad, Pernille; Wyller, Torgeir Bruun; Saltvedt, Ingvild; Beyer, Mona Kristiansen (Peer reviewed; Journal article, 2021)
      Background Chronic brain pathology and pre-stroke cognitive impairment (PCI) is predictive of post-stroke dementia. The aim of the current study was to measure pre-stroke neurodegenerative and vascular disease burden ...