Browsing NTNU Open by Author "Klepper, Kjetil"

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    • Assessment of composite motif discovery methods 

      Klepper, Kjetil; Sandve, Geir Kjetil; Abul, Osman; Johansen, Jostein; Drabløs, Finn (Journal article; Peer reviewed, 2008)
      Background: Computational discovery of regulatory elements is an important area of bioinformatics research and more than a hundred motif discovery methods have been published. Traditionally, most of these methods have ...

    • c-Myb Binding Sites in Haematopoietic Chromatin Landscapes 

      Bengtsen, Mads; Klepper, Kjetil; Gundersen, Sveinung; Cuervo, Ignacio; Drabløs, Finn; Hovig, Johannes Eivind; Sandve, Geir Kjetil F.; Gabrielsen, Odd Stokke; Eskeland, Ragnhild (Journal article, 2015)
      Strict control of tissue-specific gene expression plays a pivotal role during lineage commit- ment. The transcription factor c-Myb has an essential role in adult haematopoiesis and func- tions as an oncogene when rearranged ...

    • Genetic and molecular functional characterization of variants within TNFSF13B, a positional candidate preeclampsia susceptibility gene on 13q 

      Fenstad, Mona Høysæter; Johnson, Matthew; Roten, Linda Tømmerdal; Aas, Per Arne; Forsmo, Siri; Klepper, Kjetil; East, Christine; Abraham, Lawrence j.; Blangero, John; Brennecke, Shaun P.; Austgulen, Rigmor; Moses, Eric K (Journal article; Peer reviewed, 2010)
      Background: Preeclampsia is a serious pregnancy complication, demonstrating a complex pattern of inheritance. The elucidation of genetic liability to preeclampsia remains a major challenge in obstetric medicine. We have ...

    • Integrated approaches for motif discovery in genomic regions 

      Klepper, Kjetil (Doktoravhandlinger ved NTNU, 1503-8181; 2013:143, Doctoral thesis, 2013)
      Recipes for all the proteins that are needed by an organism are described in its genes which are encoded in DNA. In order to create a new protein, a copy of the DNA recipe must first be transcribed into RNA and this ...

    • MotifLab: a tools and data integration workbench for motif discovery and regulatory sequence analysis 

      Klepper, Kjetil; Drabløs, Finn (Journal article; Peer reviewed, 2013)
      Background: Traditional methods for computational motif discovery often suffer from poor performance. In particular, methods that search for sequence matches to known binding motifs tend to predict many non-functional ...

    • Norwegian e-Infrastructure for Life Sciences (NeLS) 

      Tekle, Kidane M; Gundersen, Sveinung; Klepper, Kjetil; Bongo, Lars Ailo; Raknes, Inge Alexander; Li, Xiaxi; Zhang, Wei; Andreetta, Christian; Mulugeta, Teshome Dagne; Kalaš, Matúš; Rye, Morten Beck; Hjerde, Erik; Antony Samy, Jeevan Karloss; Fornous, Ghislain; Azab, Abdulrahman; Våge, Dag Inge; Hovig, Eivind; Willassen, Nils Peder; Drabløs, Finn; Nygård, Ståle; Petersen, Kjell; Jonassen, Inge (Journal article; Peer reviewed, 2018)
      The Norwegian e-Infrastructure for Life Sciences (NeLS) has been developed by ELIXIR Norway to provide its users with a system enabling data storage, sharing, and analysis in a project-oriented fashion. The system is ...