Browsing NTNU Open by Author "Klæstad, Elise"
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CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis
Valla, Marit; Klæstad, Elise; Ytterhus, Borgny; Bofin, Anna M. (Peer reviewed; Journal article, 2022)CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and ... -
Long term trends of breast cancer incidence according to proliferation status
Klæstad, Elise; Opdahl, Signe; Raj, Sunil Xavier; Valla, Marit; Bofin, Anna M. (Peer reviewed; Journal article, 2022)Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. ... -
MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes
Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J; Ytterhus, Borgny; Wik, Elisabeth; Bofin, Anna Mary; Valla, Marit (Peer reviewed; Journal article, 2020)Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 ... -
Påvirker 5-metylcytosin i det humane genom fjerning av uracil?
Klæstad, Elise (Master thesis, 2020)UNG2 (uracil DNA-glykosylase) er det dominerende enzymet som fjerner uracil i det humane genomet. Metylert cytosin (5-metylcytosin (5-mC)) utgjør omtrent 1% av det humane DNA, og er med det den vanligste epigenetiske ... -
Proliferation in molecular subtypes of breast cancer
Klæstad, Elise (Doctoral theses at NTNU;2023:30, Doctoral thesis, 2023)Breast cancer is a heterogeneous disease. Using immunohistochemistry (IHC) and in situ hybridization (ISH) breast cancers can be divided into molecular subtypes with different prognosis and response to treatment. Increased ...