Browsing NTNU Open by Author "Kissova, Miroslava"

Now showing items 1-3 of 3

    • Investigating the anti-tumoural effect of novel therapeutics in cell lines generated from patient-derived glioblastoma organoids 

      Lervåg, Hannah Lovise Bjørkavoll (Master thesis, 2024)
      Glioblastom (GBM) er klassifisert som en grad 4 hjernesvulst og er beryktet for sin aggressive og diffuse vekst. Etter diagnose har kreften en median overlevelse på under 15 måneder. Betydelige utfordringer oppstår på grunn ...

    • A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment 

      Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; lång, anna ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava; Almaas, Runar; Kusnierczyk, Anna; Siller, Richard; Shahrour, Maher; Al-Ashhab, Motee; Abu-Libdeh, Bassam; Tang, Wannan; Slupphaug, Geir; Elpeleg, Orly; Bøe, Stig Ove; Eide, Lars; Sullivan, Gareth John; Rinholm, Johanne Egge; Song, Hongjun; Ming, Guo-li; van Loon, Barbara; Edvardson, Simon; Ye, Jing; Bjørås, Magnar (Peer reviewed; Journal article, 2023)
      Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant ...

    • A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres 

      Mentegari, Elisa; Bertoletti, Federica; Kissova, Miroslava; Zucca, Elisa; Galli, Silvia; Tagliavini, Giulia; Garbelli, Anna; Maffia, Antonio; Bione, Silvia; Ferrari, Elena; d'Adda di Fagagna, Fabrizio; Francia, Sofia; Sabbioneda, Simone; Chen, Liuh-Yow; Lingner, Joachim; Bergoglio, Valerie; Hoffmann, Jean-Sebastien; Hübscher, Ulrich; Crespan, Emmanuele; Maga, Giovanni (Peer reviewed; Journal article, 2021)
      Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and ...