Browsing NTNU Open by Author "Kirsebom, Bjørn-Eivind"
Now showing items 1-13 of 13
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The ANeED study – ambroxol in new and early dementia with Lewy bodies (DLB): protocol for a phase IIa multicentre, randomised, double-blinded and placebo-controlled trial
Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Kirsebom, Bjørn-Eivind; Selnes, Per; Fløvig, John Christian Jøraholmen; Knapskog, Anne Brita; Skogseth, Ragnhild Eide; Hubbers, Jessica; Holst-Larsen, Elin; Rongve, Arvid (Peer reviewed; Journal article, 2023)Background: Currently, there are no disease-modifying pharmacological treatment options for dementia with Lewy bodies (DLB). The hallmark of DLB is pathological alpha-synuclein (aS) deposition. There are growing amounts ... -
Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
Kirsebom, Bjørn-Eivind; Nordengen, Kaja; Selnes, Per; Waterloo, Knut; Torsetnes, Silje Bøen; Gisladottir, Berglind; Brix, Britta; Eugeen, Vanmechelen; Bråthen, Geir; Hessen, Erik; Aarsland, Dag; Fladby, Tormod (Journal article; Peer reviewed, 2018)Introduction The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ) clearance. We hypothesize that ... -
Demographically adjusted CERAD wordlist test norms in a Norwegian sample from 40 to 80 years
Kirsebom, Bjørn-Eivind; Espenes, Ragna; Hessen, Erik; Waterloo, Knut; Johnsen, Stein Harald; Gundersen, Elisabeth; Sando, Sigrid Botne; Grøntvedt, Gøril Rolfseng; Timón, Santiago; Fladby, Tormod (Journal article; Peer reviewed, 2019)Background/Objective: In recent years, several slightly younger cohorts have been established in order to study the preclinical and prodromal phases of dementia. The Consortium to Establish a Registry for Alzheimer’s Disease ... -
Demographically adjusted trail making test norms in a Scandinavian sample from 41 to 84 years
Espenes, Johan Jacob; Hessen, Erik; Eliassen, Ingvild Vøllo; Waterloo, Knut; Eckerström, Marie; Sando, Sigrid Botne; Timón, Santiago; Wallin, Anders; Fladby, Tormod; Kirsebom, Bjørn-Eivind (Peer reviewed; Journal article, 2020)Objective The trail making test (TMT) is one of the most widely used neuropsychological tests. TMT-A provides measures of visual scanning/visuomotor speed and TMT-B involves additional demands on executive functions. ... -
Glial activation and inflammation along the Alzheimer's disease continuum
Nordengen, Kaja; Kirsebom, Bjørn-Eivind; Henjum, Kristi; Selnes, Per; Gisladottir, Berglind; Wettergreen, Marianne; Torsetnes, Silje Bøen; Grøntvedt, Gøril Rolfseng; Waterloo, Knut; Aarsland, Dag; Nilsson, Lars; Fladby, Tormod (Journal article; Peer reviewed, 2019)Background Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer’s disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum, ... -
In Brief Neuropsychological Assessment, Amnestic Mild Cognitive Impairment (MCI) Is associated with Cerebrospinal Fluid Biomarkers for Cognitive Decline in Contrast to the Prevailing NIA-AA MCI Criterion
Hessen, Erik; Kirsebom, Bjørn-Eivind; Eriksson, Cecilia Magdalena; Eliassen, Carl Fredrik Andestad; Nakling, Arne; Bråthen, Geir; Waterloo, Knut; Aarsland, Dag; Fladby, Tormod (Journal article; Peer reviewed, 2019)Background: In the care of persons with cognitive problems, it is important to use a valid mild cognitive impairment (MCI) criterion that discriminates well between normal and pathological aging. Objective: To find ... -
Investigating the relationship between allocentric spatial working memory and biomarker status in preclinical and prodromal Alzheimer’s disease.
Lorentzen, Ingrid Myrvoll; Espenes, Johan Jacob; Eliassen, Ingvild Vøllo; Hessen, Erik; Waterloo, Knut K; Nakling, Arne Exner; Gisladottir, Berglind; Jarholm, Jonas Alexander; Fladby, Tormod; Kirsebom, Bjørn-Eivind (Peer reviewed; Journal article, 2023)The 4 Mountain Test (4MT) is a test of allocentric spatial working memory and has been proposed as an earlier marker of predementia Alzheimer’s disease (AD) than episodic verbal memory. We here compare the 4MT to the CERAD ... -
Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort
Jarholm, Jonas Alexander; Bjørnerud, Atle; Dalaker, Turi Olene; Akhavi, Mehdi Sadat; Kirsebom, Bjørn-Eivind; Pålhaugen, Lene; Nordengen, Kaja; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Teceläo, Sandra Raquel Ramos; Fladby, Tormod; Selnes, Per (Peer reviewed; Journal article, 2023)Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical ... -
Predictive and diagnostic utility of brief neuropsychological assessment in detecting Alzheimer's pathology and progression to dementia
Eliassen, Ingvild Vøllo; Fladby, Tormod; Kirsebom, Bjørn-Eivind; Waterloo, Knut; Eckerström, Marie; Wallin, Anders; Bråthen, Geir; Aarsland, Dag; Hessen, Erik (Peer reviewed; Journal article, 2020)Objective: To assess the role of brief neuropsychological assessments in prediction and identification of Alzheimer’s disease (AD) pathology and progression to AD dementia. Method: Adults (N = 255; range = 40–81 years) ... -
Regression-Based Cognitive Change Norms Applied in Biochemically Defined Predementia Alzheimer’s Disease
Eliassen, Ingvild Vøllo; Kirsebom, Bjørn-Eivind; Fladby, Tormod; Waterloo, Knut; Sando, Sigrid Botne; Hemminghyth, Mathilde Suhr; Aarsland, Dag; Reina, Santiago Timon; Wallin, Anders; Öhman, Fredrik; Eckerström, Marie; Hessen, Erik (Peer reviewed; Journal article, 2022)Objective: We aim to develop 2-year cognitive change norms for adults ages 41–84 for six cognitive tests, and to evaluate these norms in groups with AD biomarkers. Background: Practice effects are common in repeated ... -
Regression-based norms for the FAS phonemic fluency test for ages 40–84 based on a Norwegian sample
Lorentzen, Ingrid Myrvoll; Espenes, Johan Jacob; Hessen, Erik; Waterloo, Knut; Bråthen, Geir; Timón, Santiago; Aarsland, Dag; Fladby, Tormod; Kirsebom, Bjørn-Eivind (Journal article; Peer reviewed, 2021)The FAS phonemic fluency test is a commonly used neuropsychological test of executive function and processing speed. Although Norwegian discrete norms have been developed for the FAS test, American regression-based norms ... -
Regression‐based normative data for the Rey Auditory Verbal Learning Test in Norwegian and Swedish adults aged 49–79 and comparison with published norms
Espenes, Jacob; Eliassen, Ingvild Vøllo; Öhman, Fredrik; Hessen, Erik; Waterloo, Knut K; Eckerström, Marie; Lorentzen, Ingrid Myrvoll; Øien-Bergland, Cecilie; Niska, Madelene Halvari; Reina, Santiago Timon; Wallin, Anders; Fladby, Tormod; Kirsebom, Bjørn-Eivind (Peer reviewed; Journal article, 2022)The Rey Auditory Verbal Learning Test (RAVLT) is a widely used measure of episodic verbal memory. To our knowledge, culturally adapted and demographically adjusted norms for the RAVLT are currently not available for Norwegian ... -
Stable cerebrospinal fluid neurogranin and β-site amyloid precursor protein cleaving enzyme 1 levels differentiate predementia Alzheimer's disease patients
Kirsebom, Bjørn-Eivind; Richter, Grit; Nordengen, Kaja; Aarsland, Dag; Bråthen, Geir; Tijms, Betty M; Visser, Pieter Jelle; Nilsson, Johanna; Selnes, Per; Kramberger, Milica G.; Winblad, Bengt; Waterloo, Knut; Gísladóttir, Berglind; Blennow, Kaj; Fladby, Tormod (Peer reviewed; Journal article, 2022)Cerebrospinal fluid (CSF) β-site amyloid precursor protein cleaving enzyme 1 (BACE1), neurogranin and the neurogranin/BACE1 ratio are proposed markers for Alzheimer’s disease. BACE1 is also a drug target. However, CSF ...