• Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation 

      Pinto, Sneha M.; Kim, Hera; Subbannayya, Yashwanth; Giambelluca, Miriam S.; Bösl, Korbinian; Ryan, Liv; Sharma, Animesh; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2021)
      Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage ...
    • Decoding the Metabolic Reprogramming Underlying Toll-like Receptor Signaling 

      Kim, Hera (Doctoral theses at NTNU;2021:297, Doctoral thesis, 2021)
    • Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells 

      Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.; Bjørås, Magnar; Espevik, Terje; Kaynov, Denis; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      COVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced extensive evidence on host-pathogen interactions and potential therapeutic ...
    • Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo 

      Nilsen, Kaja Elisabeth; Zhang, Boyao; Skjesol, Astrid; Ryan, Liv; Vagle, Hilde; Bøe, Maren Helene; Orning, Pontus; Kim, Hera; Bakke, Siril Skaret; Elamurugan, Kirusika; Mestvedt, Ingvild Bergdal; Stenvik, Jørgen; Husebye, Harald; Lien, Egil; Espevik, Terje; Yurchenko, Mariya (Peer reviewed; Journal article, 2023)
      Inflammation plays a crucial role in the development and progression of many diseases, and is often caused by dysregulation of signalling from pattern recognition receptors, such as TLRs. Inhibition of key protein–protein ...
    • The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2 

      Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Journal article; Peer reviewed, 2019)
      Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ...
    • The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2 

      Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Peer reviewed; Journal article, 2019)
      Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ...
    • UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis 

      Kim, Hera; Subbannayya, Yashwanth; Humphries, Fiachra; Skjesol, Astrid; Pinto, Sneha M.; Giambelluca, Miriam; Espevik, Terje; Fitzgerald, Katherine A.; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2021)
      Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. Activation of ...