Browsing NTNU Open by Author "Kaynov, Denis"

Now showing items 1-5 of 5

    • Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in nonhuman primates 

      Hermet, Paule; Delache, Benoît; Herate, Cecile; Wolf, Esther; Kivi, Gaily; Juronen, Erkki; Mumm, Karl; Žusinaite, Eva; Kaynov, Denis; Sankovski, Eve; Virumäe, Kai; Planken, Anu; Merits, Andres; Besaw, Jessica E.; Yee, Ai Woon; Morizumi, Takefumi; Kim, Kyumhyuk; Kuo, Anling; Berriche, Asma; Dereuddre-Bosquet, Nathalie; Sconosciuti, Quentin; Naninck, Thibaut; Relouzat, Francis; Cavarelli, Mariangela; Wilson, Derek; Ernst, Oliver P.; Männik, Andres; LeGrand, Roger; Ustav, Mart (Peer reviewed; Journal article, 2023)
      The COVID-19 pandemic represents a global challenge that has impacted and is expected to continue to impact the lives and health of people across the world for the foreseeable future. The rollout of vaccines has provided ...

    • Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response 

      Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi; Crombag, Marie-Rose B.S.; Peppelenbosch, Maikel P.; Kaynov, Denis; Pan, Qiuwei (Peer reviewed; Journal article, 2023)
      Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ...

    • Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells 

      Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.; Bjørås, Magnar; Espevik, Terje; Kaynov, Denis; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      COVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced extensive evidence on host-pathogen interactions and potential therapeutic ...

    • A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery 

      Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Heidi Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, D; Fossum, Even; Vikse, Elisabeth Lea; Albecka, Anna; Ianevski, Aleksandr; Kaynov, Denis; Karlsen, Karine Flem; Sakya, Siri Aastedatter; Nyquist-Andersen, Mari; gjølberg, torleif; Moe, Morten Carsten; Bjørås, Magnar; Sandlie, Inger; James, Leo C.; Andersen, Jan Terje (Peer reviewed; Journal article, 2023)
      Immunocompromised patients often fail to raise protective vaccine-induced immunity against the global emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Although monoclonal antibodies have ...

    • Therapeutic Effectiveness of Interferon-α2b against COVID-19 with Community-Acquired Pneumonia: The Ukrainian Experience 

      Kamyshnyi, Aleksandr; Koval, Halyna; Kobevko, Olha; Buchynskyi, Mykhailo; Oksenych, Valentyn; Kaynov, Denis; Lyubomirskaya, Katerina; Kamyshna, Iryna; Potters, Geert; Moshynets, Olena (Peer reviewed; Journal article, 2023)
      Despite several targeted antiviral drugs against SARS-CoV-2 currently being available, the application of type I interferons (IFNs) still deserves attention as an alternative antiviral strategy. This study aimed to assess ...