• Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial 

      Ikeme, Jesse C.; Katz, Ronit; Muiru, Anthony N.; Estrella, Michelle M.; Scherzer, Rebecca; Garimella, Pranav S.; Hallan, Stein; Peralta, Carmen A.; Ix, Joachim H.; Shlipak, Michael G. (Peer reviewed; Journal article, 2022)
      BACKGROUND Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule ...
    • Estimated Kidney Tubular Secretion and Kidney, Cardiovascular, and Mortality Outcomes in CKD: The Systolic Blood Pressure Intervention Trial 

      Ascher, Simon B.; Shlipak, Michael G.; Katz, Ronit; Bullen, Alexander L.; Scherzer, Rebecca; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Seegmiller, Jesse C.; Ix, Joachim H.; Garimella, Pranav S. (Peer reviewed; Journal article, 2022)
      Rational & Objective Many drugs, metabolites, and toxins are cleared by the kidneys via tubular secretion. Whether novel endogenous measures of tubular secretion provide information about kidney, cardiovascular, and ...
    • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function 

      Pattaro, Cristian; Teumer, Alexander; Gorski, Mathias; Chu, Audrey Y.; Li, Man; Mijatovic, Vladan; Garnaas, Maija; Tin, Adrienne; Sorice, Rossella; Li, Yong; Taliun, Daniel; Olden, Matthias; Foster, Meredith; Yang, Qiong; Chen, Ming-Huei; Pers, Tune H.; Johnson, Andrew D.; Ko, Yi-An; Fuchsberger, Christian; Tayo, Bamidele; Nalls, Michael; Feitosa, Mary F.; Isaacs, Aaron; Dehghan, Abbas; D'Adamo, Pio; Adeyemo, Adebowale; Dieffenbach, Aida Karina; Zonderman, Alan B.; Nolte, Ilja M.; van der Most, Peter J.; Wright, Alan F.; Shuldiner, Alan R.; Morrison, Alanna C.; Hofman, Albert; Smith, Albert V.; Dreisbach, Albert W.; Franke, Andre; Uitterlinden, André G.; Metspalu, Andres; Tonjes, Anke; Lupo, Antonio; Robino, Antonietta; Johansson, Åsa; Demirkan, Ayse; Kollerits, Barbara; Freedman, Barry I.; Ponte, Belen; Oostra, Ben A.; Paulweber, Bernhard; Krämer, Bernhard K.; Mitchell, Braxton D.; Buckley, Brendan M.; Peralta, Carmen A.; Hayward, Caroline; Helmer, Catherine; Rotimi, Charles N.; Shaffer, Christian M.; Müller, Christian; Sala, Cinzia; Van Duijn, Cornelia M.; Saint-Pierre, Aude; Ackermann, Daniel; Shriner, Daniel; Ruggiero, Daniela; Toniolo, Daniela; Lu, Yingchang; Cusi, Daniele; Czamara, Darina; Ellinghaus, David; Siscovick, David S; Ruderfer, Douglas; Gieger, Christian; Grallert, Harald; Rochtchina, Elena; Atkinson, Elizabeth J; Holliday, Elizabeth G; Boerwinkle, Eric; Salvi, Erika; Bottinger, Erwin P; Murgia, Federico; Rivadeneira, Fernando; Ernst, Florian; Kronenberg, Florian; Hu, Frank B; Navis, Gerjan J; Curhan, Gary C; Ehret, George B; Homuth, Georg; Coassin, Stefan; Thun, Gian-Andri; Pistis, Giorgio; Gambaro, Giovanni; Malerba, Giovanni; Montgomery, Grant W; Eiriksdottir, Gudny; Jacobs, Gunnar; Li, Guo; Wichmann, H-Erich; Campbell, Harry; Schmidt, Helena; Wallaschofski, Henri; Völzke, Henry; Brenner, Hermann; Kroemer, Heyo K; Kramer, Holly; Lin, Honghuang; Leach, I Mateo; Ford, Ian; Guessous, Idris; Rudan, Igor; Prokopenko, Inga; Borecki, Ingrid; Heid, Iris M; Kolcic, Ivana; Persico, Ivana; Jukema, J Wouter; Wilson, James F; Felix, Janine F; Divers, Jasmin; Lambert, Jean-Charles; Stafford, Jeanette M; Gaspoz, Jean-Michel; Smith, Jennifer A; Faul, Jessica D; Wang, Jie Jin; Ding, Jingzhong; Hirschhorn, Joel N; Attia, John; Whitfield, John B; Chalmers, John; Viikari, Jorma; Coresh, Josef; Denny, Joshua C; Karjalainen, Juha; Fernandes, Jyotika K; Endlich, Karlhans; Butterbach, Katja; Keene, Keith L; Lohman, Kurt; Portas, Laura; Launer, Lenore J; Lyytikäinen, Leo-Pekka; Yengo, Loic; Franke, Lude; Ferrucci, Luigi; Rose, Lynda M; Kedenko, Lyudmyla; Rao, Madhumathi; Struchalin, Maksim; Kleber, Marcus E; Cavalieri, Margherita; Haun, Margot; Cornelis, Marilyn C; Ciullo, Marina; Pirastu, Mario; De Andrade, Mariza; McEvoy, Mark A; Woodward, Mark; Adam, Martin; Cocca, Massimiliano; Nauck, Matthias; Imboden, Medea; Waldenberger, Melanie; Pruijm, Menno; Metzger, Marie; Stumvoll, Michael; Evans, Michele K; Sale, Michele M; Kähönen, Mika; Boban, Mladen; Bochud, Murielle; Rheinberger, Myriam; Verweij, Niek; Bouatia-Naji, Nabila; Martin, Nicholas G; Hastie, Nick; Probst-Hensch, Nicole; Soranzo, Nicole; Devuyst, Olivier; Raitakari, Olli; Gottesman, Omri; Franco, Oscar H; Polasek, Ozren; Gasparini, Paolo; Munroe, Patricia B; Ridker, Paul M; Mitchell, Paul; Muntner, Paul; Meisinger, Christa; Smit, Johannes H; Abecasis, Goncalo R; Adair, Linda S; Alexander, Myriam; Altshuler, David; Amin, Najaf; Arking, Dan E; Arora, Pankaj; Aulchenko, Yurii; Bakker, Stephan JL; Bandinelli, Stefania; Barroso, Ines; Beckmann, Jacques S; Beilby, John P; Bergman, Richard N; Bergmann, Sven; Bis, Joshua C; Boehnke, Michael; Bonnycastle, Lori L; Bornstein, Stefan R; Bots, Michiel L; Bragg-Gresham, Jennifer L; Brand, Stefan-Martin; Brand, Eva; Braund, Peter S; Brown, Morris J; Burton, Paul R; Casas, Juan P; Caulfield, Mark J; Chakravarti, Aravinda; Chambers, John C; Chandak, Giriraj R; Chang, Yen-Pei C; Charchar, Fadi J; Chaturvedi, Nish; Cho, Yoon Shin; Clarke, Robert; Collins, Francis S; Collins, Rory; Connell, John M; Cooper, Jackie A; Cooper, Matthew N; Cooper, Richard S; Corsi, Anna Maria; Dörr, Marcus; Dahgam, Santosh; Danesh, John; Smith, George Davey; Day, Ian NM; Deloukas, Panos; Denniff, Matthew; Dominiczak, Anna F; Dong, Yanbin; Doumatey, Ayo; Elliott, Paul; Elosua, Roberto; Erdmann, Jeanette; Eyheramendy, Susana; Farrall, Martin; Fava, Cristiano; Forrester, Terrence; Fowkes, F Gerald R; Fox, Ervin R; Frayling, Timothy M; Galan, Pilar; Ganesh, Santhi K; Garcia, Melissa; Gaunt, Tom R; Glazer, Nicole L; Go, Min Jin; Goel, Anuj; Grässler, Jurgen; Grobbee, Diederick E; Groop, Leif; Guarrera, Simonetta; Guo, Xiuqing; Hadley, David; Hamsten, Anders; Han, Bok-Ghee; Hardy, Rebecca; Hartikainen, Anna-Liisa; Heath, Simon; Heckbert, Susan R; Hedblad, Bo; Hercberg, Serge; Hernandez, Dena; Hicks, Andrew A; Hilton, Gina; Hingorani, Aroon D; Hoffman Bolton, Judith A; Hopewell, Jemma C; Howard, Philip; Humphries, Steve E; Hunt, Steven C; Hveem, Kristian; Ikram, M Arfan; Islam, Muhammad; Iwai, Naoharu; Jarvelin, Marjo-Riitta; Jackson, Anne U; Jafar, Tazeen H; Janipalli, Charles S; Johnson, Toby; Kathiresan, Sekar; Khaw, Kay-Tee; Kim, Hyung-Lae; Kinra, Sanjay; Kita, Yoshikuni; Kivimaki, Mika; Kooner, Jaspal S; Kumar, MJ Kranthi; Kuh, Diana; Kulkarni, Smita R; Kumari, Meena; Kuusisto, Johanna; Kuznetsova, Tatiana; Laakso, Markku; Laan, Maris; Laitinen, Jaana; Lakatta, Edward G; Langefeld, Carl D; Larson, Martin G; Lathrop, Mark; Lawlor, Debbie A; Lawrence, Robert W; Lee, Jong-Young; Lee, Nanette R; Levy, Daniel; Li, Yali; Longstreth, Will T; Luan, Jian'an; Lucas, Gavin; Ludwig, Barbara; Mangino, Massimo; Mani, K Radha; Marmot, Michael G; Mattace-Raso, Francesco US; Matullo, Giuseppe; McArdle, Wendy L; McKenzie, Colin A; Meitinger, Thomas; Melander, Olle; Meneton, Pierre; Meschia, James F; Miki, Tetsuro; Milaneschi, Yuri; Mohlke, Karen L; Mooser, Vincent; Morken, Mario A; Morris, Richard W; Mosley, Thomas H; Najjar, Samer; Narisu, Narisu; Newton-Cheh, Christopher; Nguyen, Khanh-Dung Hoang; Nilsson, Peter; Nyberg, Fredrik; O'Donnell, Christopher J; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ong, Rick Twee-Hee; Ongen, Halit; Onland-Moret, N Charlotte; O'Reilly, Paul F; Org, Elin; Orru, Marco; Palmas, Walter; Palmen, Jutta; Palmer, Lyle J; Palmer, Nicholette D; Parker, Alex N; Peden, John F; Peltonen, Leena; Perola, Markus; Pihur, Vasyl; Platou, Carl Geoffrey Parrinder; Plump, Andrew; Prabhakaran, Dorairajan; Psaty, Bruce M; Raffel, Leslie J; Rao, Dabeeru C; Rasheed, Asif; Ricceri, Fulvio; Rice, Kenneth M; Rosengren, Annika; Rotter, Jerome I; Rudock, Megan E; Sober, Siim; Salako, Tunde; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J; Schwartz, Steven M; Schwarz, Peter EH; Scott, Laura J; Scott, James; Scuteri, Angelo; Sehmi, Joban S; Seielstad, Mark; Seshadri, Sudha; Sharma, Pankaj; Shaw-Hawkins, Sue; Shi, Gang; Shrine, Nick RG; Sijbrands, Eric JG; Sim, Xueling; Singleton, Andrew; Sjögren, Marketa; Smith, Nicholas L; Artigas, Maria Soler; Spector, Tim D; Staessen, Jan A; Stancakova, Alena; Steinle, Nanette I; Strachan, David P; Stringham, Heather M; Sun, Yan V; Swift, Amy J; Tabara, Yasuharu; Tai, E-Shyong; Talmud, Philippa J; Taylor, Andrew; Terzic, Janos; Thelle, Dag Steinar; Tobin, Martin D; Tomaszewski, Maciej; Tripathy, Vikal; Tuomilehto, Jaakko; Tzoulaki, Ioanna; Uda, Manuela; Ueshima, Hirotsugu; Uiterwaal, Cuno SPM; Umemura, Satoshi; Van Der Harst, Pim; Van Der Schouw, Yvonne T; Van Gilst, Wiek H; Vartiainen, Erkki; Vasan, Ramachandran S; Veldre, Gudrun; Verwoert, Germaine C; Viigimaa, Margus; Vinay, DG; Vineis, Paolo; Voight, Benjamin F; Vollenweider, Peter; Wagenknecht, Lynne E; Wain, Louise V; Wang, Xiaoling; Wang, Thomas J; Wareham, Nicholas J; Watkins, Hugh; Weder, Alan B; Whincup, Peter H; Wiggins, Kerri L; Witteman, Jacqueline CM; Wong, Andrew; Wu, Ying; Yajnik, Chittaranjan S; Yao, Jie; Young, JH; Zelenika, Diana; Zhai, Guangju; Zhang, Weihua; Zhang, Feng; Zhao, Jing Hua; Zhu, Haidong; Zhu, Xiaofeng; Zitting, Paavo; Zukowska-Szczechowska, Ewa; Okada, Yukinori; Wu, Jer-Yuarn; Gu, Dongfeng; Takeuchi, Fumihiko; Takahashi, Atsushi; Maeda, Shiro; Tsunoda, Tatsuhiko; Chen, Peng; Lim, Su-Chi; Wong, Tien-Yin; Liu, Jianjun; Young, Terri L; Aung, Tin; Teo, Yik-Ying; Kim, Young Jin; Kang, Daehee; Chen, Chien-Hsiun; Tsai, Fuu-Jen; Chang, Li-Ching; Fann, S-J Cathy; Mei, Hao; Hixson, James E; Chen, Shufeng; Katsuya, Tomohiro; Isono, Masato; Albrecht, Eva; Yamamoto, Kazuhiko; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Kato, Norihiro; He, Jiang; Chen, Yuan-Tsong; Tanaka, Toshihiro; Reilly, Muredach P; Schunkert, Heribert; Assimes, Themistocles L; Hall, Alistair; Hengstenberg, Christian; König, Inke R; Laaksonen, Reijo; McPherson, Ruth; Thompson, John R; Thorsteinsdottir, Unnur; Ziegler, Andreas; Absher, Devin; Chen, Li; Cupples, L Adrienne; Halperin, Eran; Li, Mingyao; Musunuru, Kiran; Preuss, Michael; Schillert, Arne; Thorleifsson, Gudmar; Wells, George A; Holm, Hilma; Roberts, Robert; Stewart, Alexandre FR; Fortmann, Stephen; Go, Alan; Hlatky, Mark; Iribarren, Carlos; Knowles, Joshua; Myers, Richard; Quertermous, Thomas; Sidney, Steven; Risch, Neil; Tang, Hua; Blankenberg, Stefan; Schnabel, Renate; Sinning, Christoph; Lackner, Karl J; Tiret, Laurence; Nicaud, Viviane; Cambien, Francois; Bickel, Christoph; Rupprecht, Hans J; Perret, Claire; Proust, Carole; Munzel, Thomas F; Barbalic, Maja; Chen, Ida Yii-Der; Demissie-Banjaw, Serkalem; Folsom, Aaron; Lumley, Thomas; Marciante, Kristin; Taylor, Kent D; Volcik, Kelly; Gretarsdottir, Solveig; Gulcher, Jeffrey R; Kong, Augustine; Stefansson, Kari; Thorgeirsson, Gudmundur; Andersen, Karl; Fischer, Marcus; Grosshennig, Anika; Linsel-Nitschke, Patrick; Stark, Klaus; Schreiber, Stefan; Aherrahrou, Zouhair; Bruse, Petra; Doering, Angela; Klopp, Norman; Diemert, Patrick; Loley, Christina; Medack, Anja; Nahrstedt, Janja; Peters, Annette; Wagner, Arnika K; Willenborg, Christina; Böhm, Bernhard O; Dobnig, Harald; Grammer, Tanja B; Hoffmann, Michael M; Meinitzer, Andreas; Winkelmann, Bernhard R; Pilz, Stefan; Renner, Wilfried; Scharnagl, Hubert; Stojakovic, Tatjana; Tomaschitz, Andreas; Winkler, Karl; Guiducci, Candace; Burtt, Noel; Gabriel, Stacey B; Dandona, Sonny; Jarinova, Olga; Qu, Liming; Wilensky, Robert; Matthai, William; Hakonarson, Hakon H; Devaney, Joe; Burnett, Mary Susan; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Knouff, Christopher W; Waterworth, Dawn M; Walker, Max C; Epstein, Stephen E; Rader, Daniel J; Nelson, Christopher P; Wright, Benjamin J; Balmforth, Anthony J; Ball, Stephen G; Loehr, Laura R; Rosamond, Wayne D; Benjamin, Emelia; Haritunians, Talin; Couper, David; Murabito, Joanne; Wang, Ying A; Stricker, Bruno H; Chang, Patricia P; Willerson, James T; Felix, Stephan B; Watzinger, Norbert; Aragam, Jayashri; Zweiker, Robert; Lind, Lars; Rodeheffer, Richard J; Greiser, Karin Halina; Deckers, Jaap W; Stritzke, Jan; Ingelsson, Erik; Kullo, Iftikhar; Haerting, Johannes; Reffelmann, Thorsten; Redfield, Margaret M; Werdan, Karl; Mitchell, Gary F; Arnett, Donna K; Gottdiener, John S; Blettner, Maria; Friedrich, Nele; Kovacs, Peter; Wild, Philipp S; Froguel, Philippe; Rettig, Rainer; Mägi, Reedik; Biffar, Reiner; Schmidt, Reinhold; Middelberg, Rita P S; Carroll, Robert J; Penninx, Brenda W; Scott, Rodney J; Katz, Ronit; Sedaghat, Sanaz; Wild, Sarah H; Kardia, Sharon L R; Ulivi, Sheila; Hwang, Shih-Jen; Enroth, Stefan; Kloiber, Stefan; Trompet, Stella; Stengel, Benedicte; Hancock, Stephen J; Turner, Stephen T; Rosas, Sylvia E; Stracke, Sylvia; Harris, Tamara B; Zeller, Tanja; Zemunik, Tatijana; Lehtimäki, Terho; Illig, Thomas; Aspelund, Thor; Nikopensius, Tiit; Esko, Tonu; Tanaka, Toshiko; Gyllensten, Ulf; Völker, Uwe; Emilsson, Valur; Vitart, Veronique; Aalto, Ville; Gudnason, Vilmundur; Chouraki, Vincent; Chen, Wei-Min; Igl, Wilmar; März, Winfried; Koenig, Wolfgang; Lieb, Wolfgang; Loos, Ruth J F; Liu, Yongmei; Snieder, Harold; Pramstaller, Peter P; Parsa, Afshin; O'Connell, Jeffrey R; Susztak, Katalin; Hamet, Pavel; Tremblay, Johanne; De Boer, Ian H; Böger, Carsten A; Goessling, Wolfram; Chasman, Daniel I; Köttgen, Anna; Kao, W H Linda; Fox, Caroline S. (Peer reviewed; Journal article, 2016)
      Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ...
    • Implementing the European Renal Best Practice Guidelines suggests that prediction equations work well to differentiate risk of end-stage renal disease vs. death in older patients with low estimated glomerular filtration rate 

      Hallan, Stein; Rifkin, Dena E; Potok, O Alison; Katz, Ronit; Langlo, Knut Asbjørn Rise; Bansal, Nisha; Ix, Joachim H (Journal article; Peer reviewed, 2019)
      Recent European guidelines suggest using the kidney failure risk equation (KFRE) and mortality risk equation for kidney disease (MREK) to guide decisions on whether elderly patients with chronic kidney disease should be ...
    • Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD 

      Bullen, Alexander L.; Ascher, Simon B.; Scherzer, Rebecca; Garimella, Pranav S.; Katz, Ronit; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Malhotra, Rakesh; Seegmiller, Jesse C.; Shlipak, Michael G.; Ix, Joachim H. (Peer reviewed; Journal article, 2022)
      Significance Statement SPRINT demonstrated in individuals with hypertension and high cardiovascular disease (CVD) risk that intensive BP lowering was associated with decreased risk of CVD events and all-cause mortality. ...