• Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium 

      Morris, Richard W.; Taylor, Amy E.; Fluharty, Meg E.; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Campbell, Archie; Marioni, Riccardo; Kumari, Meena; Korhonen, Tellervo; Männistö, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N.; Skaaby, Tea; Ahluwalia, Tarun Veer Singh; Treur, Jorien L.; Willemsen, Gonneke; Dale, Caroline; Wannamethee, S. Goya; Lahti, Jari; Palotie, Aarno; Räikkönen, Katri; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgård, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, David M.; Kennedy, Martin A.; Nohr, Ellen A.; Christiansen, Lene; Kyvik, Kirsten Ohm; Kuh, Diana; Watt, Graham; Eriksson, Johan G.; Whincup, Peter H.; Vink, Jacqueline M.; Boomsma, Dorret I.; Smith, George Davey; Lawlor, Debbie; Linneberg, Allan; Ford, Ian; Jukema, J. Wouter; Power, Chris; Hyppönen, Elina; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, Blair H.; Hayward, Caroline; Romundstad, Pål Richard; Sørensen, Thorkild I.A.; Munafo, Marcus R.; Sattar, Naveed (Journal article; Peer reviewed, 2015)
      Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: ...
    • Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium 

      Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken Elvestad; Bjørngaard, Johan Håkon; Flexeder, Claudia; Männistö, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Møllehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bønnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimäki, Mika; Kumari, Meena; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Power, Chris; Hyppönen, Elina; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pål Richard; Skorpen, Frank; Kaprio, Jaakko; Munafò, Marcus R.; Linneberg, Allan (Journal article; Peer reviewed, 2017)
      Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic ...
    • Obesity does not protect from subarachnoid haemorrhage: Pooled analysis of 3 large prospective Nordic cohorts 

      Rautalin, Ilari; Kaprio, Jaakko; Ingebrigtsen, Tor; Jousilahti, Pekka; Løchen, Maja-Lisa; Romundstad, Pål Richard; Salomaa, Veikko; Vik, Anne; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Sandvei, Marie Søfteland; Korja, Miikka (Journal article; Peer reviewed, 2021)
      Background and Purpose: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether ...
    • Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers 

      Taylor, Amy E; Morris, Richard W; Fluharty, Meg; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Campbell, A.; Marioni, Riccardo R.; Kumari, Meena; Hällfors, Jenni; Männistö, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N; Skaaby, Tea; Ahluwalia, Tarunveer Singh; Treur, Jorien L; Willemsen, Gonneke; Dale, Caroline; Wannamethee, SG; Lahti, J; Palotie, Aarno; Räikkönen, K; Kisialiou, Aliaksei; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgård, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, D; Kennedy, Martin A; Frayling, T; Nohr, Ellen A; Christiansen, Lene; Ohm Kyvik, K; Kuh, Diana; Watt, Graham; Eriksson, Johan; Whincup, Peter H; Vink, JM; Boomsma, Dorret I; Davey Smith, George; Lawlor, Debbie A; Linneberg, Allan; Ford, Ian; Jukema, J Wouter; Power, C; Hyppönen, E; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, BH; Hayward, Caroline; Romundstad, Pål Richard; Sørensen, Thorkild I.A.; Munafo, Marcus R; Sattar, Naveed (Journal article; Peer reviewed, 2014)
      We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a ...
    • Variants associated with HHIP expression have sex-differential effects on lung function 

      Fawcett, Katherine A.; Obeidat, Ma'en; Melbourne, Carl; Shrine, Nick; Guyatt, Anna L.; John, Catherine; Luan, Jian'an; Richmond, Anne; Moksnes, Marta R.; Granell, Raquel; Weiss, Stefan; Imboden, Medea; May-Wilson, Sebastian; Hysi, Pirro; Boutin, Thibaud S.; Portas, Laura; Flexeder, Claudia; Harris, Sarah E.; Wang, Carol A.; Lyytikäinen, Leo-Pekka; Palviainen, Teemu; Foong, Rachel E.; Keidel, Dirk; Minelli, Cosetta; Langenberg, Claudia; Bossé, Yohan; Berge, Maarten Van den; Sin, Don D.; Hao, Ke; Campbell, Archie; Porteous, David; Padmanabhan, Sandosh; Smith, Blair H.; Evans, David M.; Ring, Sue; Langhammer, Arnulf; Hveem, Kristian; Willer, Cristen J.; Ewert, Ralf; Stubbe, Beate; Pirastu, Nicola; Klaric, Lucija; Joshi, Peter K.; Patasova, Karina; Massimo, Mangino; Polasek, Ozren; Starr, John M.; Karrasch, Stefan; Strauch, Konstantin; Meitinger, Thomas; Rudan, Igor; Rantanen, Taina; Pietiläinen, Kirsi; Kähönen, Mika; Raitakari, Olli T.; Hall, GL; Sly, Peter D.; Pennell, CE; Kaprio, Jaakko; Lehtimäki, Terho; Vitart, Veronique; Deary, Ian J.; Jarvis, Deborah; Wilson, JF; Spector, Tim; Probst-Hensch, Nicole; Wareham, Nick; Völzke, Henry; Henderson, John; Strachan, David P.; Brumpton, Ben Michael; Hayward, Caroline; Hall, Ian P.; Tobin, Martin D.; Wain, Louise V. (Peer reviewed; Journal article, 2021)
      Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide ...