• A systems approach to study immuno- and neuro-modulatory properties of antiviral agents 

      Zusinaite, Eva; Ianevski, Alexandr; Niukkanen, Diana; Poranen, Minna M.; Bjørås, Magnar; Afset, Jan Egil; Tenson, Tanel; Velagapudi, Vidya; Merits, Andres; Kainov, Denis (Journal article; Peer reviewed, 2018)
      There are dozens of approved, investigational and experimental antiviral agents. Many of these agents cause serious side effects, which can only be revealed after drug administration. Identification of the side effects ...
    • An Agile Approach to Novel Recombinant Antithrombin Production for use in Biologics Development 

      DeBenedictis, Francis (Master thesis, 2019)
      Background: Sepsis is a deadly medical condition caused by a runaway inflammatory response to systemic infection in which the release of extracellular cytotoxic histones has been linked to disease progression. Heparin ...
    • Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins 

      Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik; Kakkola, Laura; Nandania, Jatin; Turunen, Laura; Ohman, Tiina; Ala-Hongisto, Hanna; Pesonen, Hanna M; Kuisma, Marika S; Honkimaa, Anni; Walton, Emma Louise; Oksenych, Valentyn; Lorey, Martina B.; Guschin, Dmitry; Shim, Jungmin; Kim, Jinhee; Than, Thoa T; Chang, So Young; Hukkanen, Veijo; Kulesskiy, Evgeny; Marjomaki, Varpu S; Julkunen, Ilkka; Nyman, Tuula Anneli; Matikainen, Sampsa; Saarela, Jani S; Sane, Famara; Hober, Didier; Gabriel, Gulsah; De Brabander, Jef K; Martikainen, Miika; Windisch, Marc P; Min, Ji-Young; Bruzzone, Roberto; Aittokallio, Tero; Vaha-Koskela, Markus; Vapalahti, Olli; Pulk, Arto; Velagapudi, Vidya; Kainov, Denis (Journal article; Peer reviewed, 2017)
      Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, ...
    • Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis 

      Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Evandro Fei; Kainov, Denis (Journal article; Peer reviewed, 2020)
      Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ...
    • Common nodes of virus–host interaction revealed through an integrated network analysis 

      Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)
      Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ...
    • Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik; Wang, Timothy Cragin; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ...
    • Discovery of Broad-Spectrum Antiviral Agents by Drug Repurposing for Rapid Response to Emergent Viral Pandemics: Building Digital Tools to Advance Translational Research 

      Yao, Rouan (Master thesis, 2021)
      The ongoing COVID-19 pandemic caused by the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in 2019 has highlighted urgency for a more efficient and comprehensive paradigm for antiviral development. ...
    • Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses 

      Ladner, Jason T.; Henson, Sierra N.; Boyle, Annalee S.; Engelbrektson, Anna L.; Fink, Zane W.; Rahee, Fatima; D'ambrozio, Jonathan; Schaecher, Kurt E.; Stone, Mars; Dong, Wenjuan; Dadwal, Sanjeet; Yu, Jianhua; Caligiuri, Michael A.; Cieplak, Piotr; Bjørås, Magnar; Fenstad, Mona H.; Nordbø, Svein Arne; Kainov, Denis; Muranaka, Norihito; Chee, Mark S.; Shiryaev, Sergey A.; Altin, John A. (Peer reviewed; Journal article, 2021)
      The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity ...
    • Expanding the activity spectrum of antiviral agents 

      Ianevski, Aleksandr; Andersen, Petter I.; Merits, Andres; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2019)
    • Identification and Tracking of Antiviral Drug Combinations 

      Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)
      Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ...
    • Influenza virus infection, interferon response, viral counter-response, and apoptosis 

      Shim, Jung Min; Kim, Jinhee; Tenson, Tanel; Min, Ji-Young; Kainov, Denis (Journal article; Peer reviewed, 2017)
      Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new ...
    • Intracellular Survival and Immune System Activation Following Viral Scavenging in Murine Liver Sinusoidal Endothelial Cells 

      Lænsman, Eirik Abrahamsen (Master thesis, 2021)
      Lever sinusformede endotelceller (LSEC) er profesjonelle endocytter med en ekstraordinær evne til å fjerne forskjellige avfallsmaterialer som kan være tilstede i blodet. LSECene blir i økende grad anerkjent som sentrale ...
    • Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018 

      Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca Jane; Tenson, Tanel; Merits, Andres; Kainov, Denis (Journal article; Peer reviewed, 2019)
      With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ...
    • Neural signaling modulates metabolism of gastric cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis; Wang, Timothy Cragin; Lundgren, Steinar; Grønbech, Jon Erik; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that ...
    • Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. 

      Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli; Lysvand, Hilde; Løseth, Kirsti; Landsem, Veslemøy Malm; Fossum, Janne; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Pettersen, Caroline Hild; Tenson, Tanel; Afset, Jan Egil; Nordbø, Svein Arne; Bjørås, Magnar; Kainov, Denis; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ...