Browsing NTNU Open by Author "Johnsen, Erik"

Now showing items 1-16 of 16

    • Antidepressive Effectiveness of Amisulpride, Aripiprazole, and Olanzapine in Patients with Schizophrenia Spectrum Disorders: A Secondary Outcome Analysis of a Pragmatic, Randomized Trial (BeSt InTro) 

      Kjelby, Eirik; Gjestad, Rolf; Fathian, Farivar; Sinkeviciute, Igne; Alisauskiene, Renata; Anda, Liss; Løberg, Else-Marie; Reitan, Solveig Klæbo; Joa, Inge; Larsen, Tor Kjetil; Rettenbacher, Maria; Berle, Jan Øystein; Fasmer, Ole Bernt; Kroken, Rune Andreas; Johnsen, Erik (Peer reviewed; Journal article, 2023)
      Background Depressive symptoms are frequent in schizophrenia and associated with a poorer outcome. Currently, the optimal treatment for depressive symptoms in schizophrenia remains undetermined. Amisulpride, aripiprazole, ...

    • Association between C-reactive protein levels and antipsychotic treatment during 12 months follow-up period after acute psychosis 

      Fathian, Farivar; Gjestad, Rolf; Kroken, Rune Andreas; Løberg, Else-Marie; Reitan, Solveig Merete Klæbo; Fleichhacker, W. Wolfgang; Rettenbacher, Maria; Larsen, Tor Ketil; Joa, Inge; Stabell, Lena Antonsen; Kjelby, Eirik; Sinkevicute, Igne; Alisauskiene, Renata; Steen, Vidar Martin; Johnsen, Erik (Peer reviewed; Journal article, 2022)
      Background - A potential role of inflammatory pathways in the pathology of schizophrenia has been suggested for at least a subgroup of patients. Elevated levels of the inflammatory marker C-reactive protein (CRP) have been ...

    • The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study 

      Larsen, Jeanette Brun; Reitan, Solveig Merete Klæbo; Løberg, Else-Marie; Rettenbacher, Maria; Bruserud, Øystein; Larsen, Tor Ketil; Anda, Liss Gøril; Bartz-Johannessen, Christoffer; Johnsen, Erik; Kroken, Rune Andreas (Peer reviewed; Journal article, 2021)
      Background In schizophrenia, impaired psychomotor speed is a common symptom predicting worse functional outcome. Inflammation causes changes in white matter integrity, which may lead to reduced psychomotor speed. Therefore, ...

    • Clinical insight among persons with schizophrenia spectrum disorders treated with amisulpride, aripiprazole or olanzapine: a semi-randomised trial 

      Stabell, Lena Antonsen; Johnsen, Erik; Kroken, Rune Andreas; Løberg, Else-Marie; Blindheim, Anne Alnes; Joa, Inge; Reitan, Solveig Klæbo; Rettenbacher, M.; Munk-Jørgensen, P.; Gjestad, Rolf (Peer reviewed; Journal article, 2023)
      Background Antipsychotic treatment may improve clinical insight. However, previous studies have reported inconclusive findings on whether antipsychotics improve insight over and above the reduction in symptoms of ...

    • Depression trajectories and cytokines in schizophrenia spectrum disorders - A longitudinal observational study 

      Hoprekstad, Gunnhild Eldhuset; Kjelby, Eirik; Gjestad, Rolf; Fathian, Farivar; Larsen, Tor Ketil; Reitan, Solveig Klæbo; Rettenbacher, Maria; Torsvik, Anja; Skrede, Silje; Johnsen, Erik; Kroken, Rune Andreas (Peer reviewed; Journal article, 2023)
      Depression occurs frequently in all phases of schizophrenia spectrum disorders. Altered activity in the immune system is seen in both depression and schizophrenia. We aimed to uncover depressive trajectories in a sample ...

    • Differential Effectiveness of Atypical Antipsychotics on Hallucinations: A Pragmatic Randomized Controlled Trial 

      Sinkeviciute, Igne; Hugdahl, Kenneth Jan; Bartz-Johannessen, Christoffer; Kroken, Rune Andreas; Løberg, Else-Marie; Kjelby, Eirik; Rettenbacher, maria; Joa, Inge; Reitan, Solveig Merete Klæbo; Alisauskiene, Renata; Fathian, Farivar; Johnsen, Erik (Peer reviewed; Journal article, 2021)
      Background Most studies investigating antipsychotic effectiveness report either total psychopathology or symptom cluster findings. Studies focusing on a separate symptom, such as hallucinations, a hallmark symptom in ...

    • Does drug use affect the efficacy of amisulpride, aripiprazole and olanzapine in patients with schizophrenia spectrum disorders? Results from a pragmatic, randomised study 

      Alisauskiene, Renata; Johnsen, Erik; Gjestad, Rolf; Kroken, Rune Andreas; Kjelby, Eirik; Sinkeviciute, Igne; Fathian, Farivar; Joa, Inge; Reitan, Solveig Klæbo; Rettenbacher, Maria; Løberg, Else-Marie (Peer reviewed; Journal article, 2023)
      Objectives Drug use is prevalent in patients with schizophrenia spectrum disorders (SSD) but there is limited knowledge about the influence of drug use on the effectiveness of antipsychotic medication. This secondary ...

    • Elevated Systemic Levels of Markers Reflecting Intestinal Barrier Dysfunction and Inflammasome Activation Are Correlated in Severe Mental Illness 

      Jensen, Søren Beck; Sheikh, Mashhood Ahmed; Akkouh, Ibrahim Ahmed; Szabo, Attila; O'Connell, Kevin Sean; Lekva, Tove; Engh, John; Agartz, Ingrid; Elvsåshagen, Torbjørn; Ormerod, Monica Bettina E. Greenwood; Weibell, Melissa Anne Elin Authen; Johnsen, Erik; Kroken, Rune Andreas; Melle, Ingrid; Drange, Ole Kristian; Nærland, Terje; Vaaler, Arne; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Peer reviewed; Journal article, 2022)
      Abstract Background and Hypothesis Gut microbiota alterations have been reported in severe mental illness (SMI) but fewer studies have probed for signs of gut barrier disruption and inflammation. We hypothesized that ...

    • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 

      Szabo, Attila; O’Connell, Kevin; Ueland, Thor; Ahmed, Mashhood Sheikh; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John Abel; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Auten Weibell, Melissa; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Peer reviewed; Journal article, 2022)
      Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...

    • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 

      Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Peer reviewed; Journal article, 2021)
      Background -Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...

    • Long term outcomes and causal modelling of compulsory inpatient and outpatient mental health care using Norwegian registry data : protocol for a controversies in psychiatry research project 

      Hofstad, Tore; Nyttingnes, Olav; Markussen, Simen; Johnsen, Erik; Killackey, Eoin; McDaid, David; Rinaldi, Miles; Dean, Kimberlie; Brinchmann, Beate; Douglas, Kevin Stewart; Gröning, Linda; Bjørkly, Stål Kapstø; Palmstierna, Tom Krisman Kule; Strømme, Maria Fagerbakke; Blindheim, Anne Alnes; Rugkåsa, Jorun; Hofmann, Bjørn Morten; Pedersen, Reidar; Widding-Havnerås, Tarjei; Rypdal, Knut; Mykletun, Arnstein (Peer reviewed; Journal article, 2023)
      Objectives: Compulsory mental health care includes compulsory hospitalisation and outpatient commitment with medication treatment without consent. Uncertain evidence of the effects of compulsory care contributes to large ...

    • Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

      Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Peer reviewed; Journal article, 2021)
      Background Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ...

    • Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study 

      Engh, John; Ueland, Thor; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Wedervang-Resell, Kirsten; Weibell, Melissa; Westlye, Lars Tjelta; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole (Peer reviewed; Journal article, 2021)
      Background Immune dysfunction has been implicated in the pathogenesis of schizophrenia and other nonaffective psychosis (SCZ), bipolar spectrum disorder (BIP) and major depressive disorder (MDD). The cytokines B cell-activating ...

    • Quality of clinical management of cardiometabolic risk factors in patients with severe mental illness in a specialist mental health care setting 

      Ringen, Petter Andreas; Lund-Stenvold, Elisabeth Haug; Andreassen, Ole; Gaarden, Torfinn Lødøen; Hartberg, Cecilie Bhandari; Johnsen, Erik; Myklatun, Silje; Osnes, Kåre; Sørensen, Kirsten; Sørensen, Kjetil; Vaaler, Arne; Tonstad, Serena; Engh, John; Høye, Anne (Peer reviewed; Journal article, 2022)
      Purpose: Cardiometabolic disease in patients with severe mental illness is a major cause of shortened life expectancy. There is sparse evidence of real-world clinical risk prevention practice. We investigated levels of ...

    • Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation 

      Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed; Osete, Jordi Requena; Agartz, Ingrid; Engh, John; Andreou, Dimitrios; Boye, Birgitte; Bøen, Erlend; Elvsåshagen, Torbjørn; Hope, Sigrun; Werner, Maren Caroline Frogner; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Drange, Ole Kristian; Morken, Gunnar; Nærland, Terje; Sørensen, Kjetil; Vaaler, Arne; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Peer reviewed; Journal article, 2022)
      Background Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated ...

    • The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations 

      Kompus, Kristiina; Falkenberg, Liv Eggset; Bless, Josef J; Johnsen, Erik; Kroken, Rune; Kråkvik, Bodil; Larøi, Frank; Løberg, Else-Marie; Vedul-Kjelsås, Einar; Westerhausen, René; Hugdahl, Kenneth (Journal article; Peer reviewed, 2013)
      Auditory verbal hallucinations (AVHs) are a subjective experience of “hearing voices” in the absence of corresponding physical stimulation in the environment. The most remarkable feature of AVHs is their perceptual quality, ...