Browsing NTNU Open by Author "Johansen, Berit"
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A Diet Rich in Carbohydrates Induces Changes in Serum microRNA Levels Associated with Type 2 Diabetes Development.
Rundblad, Sarah Amanda (Master thesis, 2012)It is known that the level of serum microRNAs, small RNA molecules involved in regulation of gene expression, is altered in diabetic patients compared to healthy individuals and that microRNAs may be involved in the ... -
A novel compound isolated from Sclerochloa dura has anti-inflammatory effects
Bukhari, Syed Majid; Feuerherm, Astrid Jullumstrø; Tunset, Hanna Maja; Isaksen, Stian Moe; Sæther, Mari; Thvedt, Thor Håkon Krane; Villa Gonzalez, Susana; Schmid, Rudolf; Brunsvik, Anders; Fuglseth, Erik; Zlatković, Bojan; Johansen, Berit; Simic, Nebojsa (Journal article; Peer reviewed, 2016)The activation of phospholipase A2 (PLA2) by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. Through cyclooxygenases ... -
A survey of NRPS genes from Planktothrix in Lake Kolbotnvannet
Ballestad, Hanne (Master thesis, 2008)Lake Kolbotnvannet is dominated by the Cyanobacteria Planktothrix. Cyanobacteria produce oligopeptides by nonribosomal peptide synthetases (NRPS), which have unknown biological functions. NRPS genes encoding the NRPS ... -
Anti-angiogenic therapy affects the relationship between tumor vascular structure and function: a correlation study between micro-CT angiography and DCE-MRI
Kim, Eugene; Cebulla, Jana; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016) -
Anti-inflammatory and antioxidant activities of Sclerochloa dura (Poaceae)
Bukhari, Syed Majid; Feuerherm, Astrid Jullumstrø; Boulfrad, Fayssal; Zlatkovic, Bojan; Johansen, Berit; Simic, Nebojsa (Journal article; Peer reviewed, 2014)The plant Sclerochloa dura is traditionally used in South-East Serbia to treat menstrual disorders characterized by pain and excessive bleeding. According to subjects’ statements, a reduction in bleeding and pain is ... -
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model
Kim, Eugene; Tunset, Hanna Maja; Cebulla, Jana; Vettukattil, Muhammad Riyas; Helgesen, Heidi; Feuerherm, Astrid Jullumstrø; Engebråten, Olav; Mælandsmo, Gunhild; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)Background: Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, ... -
Cellular Effects of Insulin in Human THP-1 Monocytes
Naderi, Jamal (Master thesis, 2015)Excess of insulin in the circulating blood relative to the level of glucose (Hyperinsulinemia) may be linked to systemic low-grade inflammation and some chronic disease such as the metabolic syndrome, type 2 diabetes ... -
Characterization of how cytosolic phospholipase A2 alpha regulate cell viability in CCRF-CEM cells, as a model for acute lymphoblastic leukaemia
Halvei, Marthe Skånøy (Master thesis, 2021)Abstract will be available on 2024-05-15 -
Characterization of Vitamin k2 FUNTIONS IN Saos-2 osteoblasts
Strand, Siv Kristine Sola (Master thesis, 2012)MK-7 as a potential treatment against osteoporosis, favoring bone formation, was explored in this thesis. Today most treatments for bone loss target suppression of osteoclastogenesis. Biological activity and cytotoxicity ... -
The Copenhagen Actinic Keratosis Study (COAKS). A decentralised clinical trial to evaluate tolerability, safety and efficacy of daily field-directed topical treatment with cytosolic phospholipase A<inf>2</inf> inhibitor, AVX001, in participants with actinic keratosis: protocol for a randomised controlled phase I/IIa trial
Ortner, Vinzent Kevin; Johansen, Berit; Kilov, Kim; Castillo Mondragón, Alejandro; Duvold, Tore; Kihl, Jesper; Ashcroft, Felicity; Feuerherm, Astrid Jullumstrø; Pind Laugesen, Charlotte; Marcker Espersen, Maiken Lise; Manole, Ionela; Isberg, Ari Pall; Andersen, Anders Daniel; Rakvaag, Elin; Zibert, John R.; Haedersdal, Merete (Peer reviewed; Journal article, 2022)ntroduction Actinic keratosis (AK) is the most common precancerous skin condition caused by long-term UV exposure. Given the high recurrence rate of 15%–53%, identifying safe and effective treatment options is warranted. ... -
cPLA2α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation
Ashcroft, Felicity; Mahammad, Nur; Flatekvål, Helene Midtun; Feuerherm, Astrid Jullumstrø; Johansen, Berit (Journal article, 2020)As a regulator of cellular inflammation and proliferation, cytosolic phospholipase A2 α (cPLA2α) is a promising therapeutic target for psoriasis; indeed, the cPLA2α inhibitor AVX001 has shown efficacy against plaque psoriasis ... -
Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen induced arthritis
Feuerherm, Astrid Jullumstrø; Dennis, Edward A.; Johansen, Berit (Journal article; Peer reviewed, 2019)Background: Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the ... -
Cytosolic phospholipase A2 alpha in aggressive breast cancer: Linking inflammation, angiogenesis, and metastasis
Tunset, Hanna Maja (Doctoral theses at NTNU;2018:340, Doctoral thesis, 2018) -
Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells
Tunset, Hanna Maja; Feuerherm, Astrid Jullumstrø; Selvik, Linn-Karina M.; Johansen, Berit; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with ... -
Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes
Sommerfelt, Randi Magnus; Feuerherm, Astrid Jullumstrø; Skuland, Trine; Johansen, Berit (Journal article; Peer reviewed, 2015)Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis leading to destruction of cartilage and bone. PLA2 enzymes are key players in inflammation regulating the release of unsaturated fatty ... -
Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes
Sommerfelt, Randi Magnus; Feuerherm, Astrid Jullumstrø; Jones, Kymry; Johansen, Berit (Journal article; Peer reviewed, 2013)Introduction: Rheumatoid arthritis (RA) is an inflammatory disease of the joint characterized by chronic synovitis causing pain, swelling and loss of function due to destruction of cartilage and bone. The complex series ... -
Detection and differentiation of breast cancer sub-types using a cPLA2a activatable fluorophore
Chiorazzo, MG; Tunset, Hanna Maja; Popov, AV; Johansen, Berit; Moestue, Siver Andreas; Delikatny, EJ (Journal article; Peer reviewed, 2019)Cytosolic phospholipase A2α (cPLA2α) has been shown to be elevated in breast cancer and is a potential biomarker in the differentiation of molecular sub-types. Using a cPLA2α activatable fluorophore, DDAO arachidonate, we ... -
Detection of Pso p27 in Prostate Cancer
Resellmo, Ester Ljones (Master thesis, 2012)AbstractThe mechanisms causing psoriasis and other autoimmune diseases are not known with certainty, although it has been indicated that the factors behind them are similar. These similarities are, among others, heredity ... -
Dietary composition, overlap and competition between impala and domestic goat as revealed by DNA metabarcoding
Fossum, Ingrid Aase Lingaas (Master thesis, 2017)In a world with a rapidly growing human population and limited resources, it is important to understand how we interact with wildlife to ensure their conservation. In Tanzania, the human population has more than tripled ... -
Effects of cPLA2a inhibition in the MDA-MB-468 cell model system for basal-like breast cancer and/or triple negative breast cancer
Hussin, Anfal (Master thesis, 2016)Basal-like breast cancer (BLBC) is a highly aggressive breast cancer sub-type and represents ~15% of all breast cancers. BLBC are often associated with early age of onset, early relapse and poor overall survival in contrast ...