Browsing NTNU Open by Author "Jager, Neeltina M."

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    • Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys 

      Jager, Neeltina M.; Venema, Leonie H.; Arykbaeva, Asel S.; Meter-Arkema, Anita H.; Ottens, Petra J.; van Kooten, Cees; Mollnes, Tom Eirik; Alwayn, Ian P. J.; Leuvenink, Henri G. D.; Pischke, Soeren (Peer reviewed; Journal article, 2022)
      Background: The gap between demand and supply of kidneys for transplantation necessitates the use of kidneys from extended criteria donors. Transplantation of these donor kidneys is associated with inferior results, reflected ...

    • Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition 

      de Boer, Eline; Sokolova, Marina; Jager, Neeltina M.; Schjalm, Camilla; Weiss, Marc G.; Liavåg, Olav Magnus Ivar; Maassen, Hanno; van Goor, Harry; Thorgersen, Ebbe Billmann; Pettersen, Kristin; Christiansen, Dorte; Ludviksen, Judith K; Jespersen, Bente; Mollnes, Tom Eirik; Leuvenink, Henri G. D.; Pischke, Soeren (Peer reviewed; Journal article, 2024)
      Normothermic machine perfusion (NMP) is a clinical strategy to reduce renal ischemia-reperfusion injury (IRI). Optimal NMP should restore metabolism and minimize IRI induced inflammatory responses. Microdialysis was used ...