• Sensing of HIV-1 by TLR8 activates human T cells and reverses latency 

      Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Zhenyi; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, Hang; Damås, Jan Kristian; Flo, Trude Helen (Journal article; Peer reviewed, 2020)
      During HIV infection, cell-to-cell transmission results in endosomal uptake of the virus by target CD4+ T cells and potential exposure of the viral ssRNA genome to endosomal Toll-like receptors (TLRs). TLRs are instrumental ...
    • TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria 

      Ehrnstrøm, Birgitta; Kojen, June Frengen; Giambelluca, Miriam; Ryan, Liv; Moen, Siv Helen; Hu, Zhenyi; Yin, Hang; Mollnes, Tom Eirik; Damås, Jan Kristian; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2020)
      We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated ...