Browsing NTNU Open by Author "Hjelde, Astrid"
Now showing items 1-7 of 7
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Blood gene expression and vascular function biomarkers in professional saturation diving
Kiboub, Fatima Zohra; Møllerløkken, Andreas; Hjelde, Astrid; Flatberg, Arnar; Loennechen, Øyvind; Eftedal, Ingrid (Journal article; Peer reviewed, 2018)Saturation diving is an established way to conduct subsea operations with human intervention. While working, the divers must acclimatize to the hyperbaric environments. In this study, genome-wide gene expression and selected ... -
Evaluating PAI-1 as a biomarker for stress in diving: human serum total PAI-1 is unaltered after 2 h dry exposures to 280 kPa hyperbaric air
Eftedal, Ingrid; Fredriksen, Hallvard Aglen; Hjelde, Astrid; Møllerløkken, Andreas (Journal article; Peer reviewed, 2015)Plasminogen activator inhibitor (PAI-1) is induced in the vasculature and secreted into the vascular lumen in response to inflammation and oxidative stress. We have previously reported a fivefold increase in plasma PAI-1 ... -
Functional profiling reveals altered metabolic activity in divers’ oral microbiota during commercial heliox saturation diving
Monnoyer, Roxane; Eftedal, Ingrid; Hjelde, Astrid; Deb, Sanjoy Kumar; Haugum, Kjersti; Lautridou, Jacky (Peer reviewed; Journal article, 2021)Background: The extreme environment in saturation diving affects all life forms, including the bacteria that reside on human skin and mucosa. The oral cavity alone is home to hundreds of different bacteria. In this study, ... -
Hemoglobin during and following a four-week commercial saturation dive to 200 meters
Luczynski, Damian; Lautridou, Jacky; Hjelde, Astrid; Monnoyer, Roxane; Eftedal, Ingrid (Journal article; Peer reviewed, 2019)Commercial saturation divers must acclimatize to hyperbaric hyperoxia in their work environment, and subsequently readjust to breathing normal air when their period in saturation is over. In this study, we measured hemoglobin ... -
Shifts in the oral microbiota during a four-week commercial saturation dive to 200 meters
Monnoyer, Roxane; Haugum, Kjersti; Lautridou, Jacky; Flatberg, Arnar; Hjelde, Astrid; Eftedal, Ingrid (Peer reviewed; Journal article, 2021)During commercial saturation diving, divers live and work under hyperbaric and hyperoxic conditions. The myriads of bacteria that live in and on the human body must adjust to the resultant hyperbaric stress. In this study, ... -
Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action
Arum, Carl-Jørgen; Gederaas, Odrun Arna; Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Hjelde, Astrid; Krokan, Hans Einar; Svaasand, Lars O.; Chen, Duan; Zhao, Chun-Mei (Journal article; Peer reviewed, 2011)Orthotopic bladder cancer model in rats mimics human bladder cancer with respect to urothelial tumorigenesis and progression. Utilizing this model at pT1 (superficial stage), we analyze the tissue responses to hexyl ... -
Using Salivary Biomarkers for Stress Assessment in Offshore Saturation Diving: a Pilot Study
Monnoyer, Roxane; Lautridou, Jacky; Deb, Sanjoy Kumar; Hjelde, Astrid; Eftedal, Ingrid (Peer reviewed; Journal article, 2021)Health monitoring during offshore saturation diving is complicated due to restricted access to the divers, the desire to keep invasive procedures to a minimum, and limited opportunity for laboratory work onboard dive support ...