Blar i NTNU Open på forfatter "Hill, Deborah Katherine"
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APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer
Søgaard, Caroline Danielsen; Moestue, Siver Andreas; Rye, Morten Beck; Kim, Jana; Nepal, Anala; Liabakk, Nina-Beate; Bachke, Siri; Bathen, Tone Frost; Otterlei, Marit; Hill, Deborah Katherine (Journal article; Peer reviewed, 2018)Docetaxel is the chemotherapeutic choice for metastatic hormone-refractory prostate cancer, however, it only marginally improves the survival rate. The purpose of the present study was to examine if a peptide ... -
Classification and biomarker identification of prostate tissue from TRAMP mice with hyperpolarized 13C-SIRA
Frahm, Anne; Hill, Deborah Katherine; Katsikis, Sotirios; Andreassen, Trygve; Ardenkjær-Larsen, Jan Henrik; Bathen, Tone Frost; Moestue, Siver Andreas; Jensen, Pernille Rose; Lerche, Mathilde (Peer reviewed; Journal article, 2021)Hyperpolarized 13C isotope resolved spectroscopy boosts NMR signal intensity, which improves signal detection and allows metabolic fluxes to be analyzed. Such hyperpolarized flux data may offer new approaches to tissue ... -
Diffusion-weighted MRI for early detection and characterization of prostate cancer in the transgenic adenocarcinoma of the mouse prostate model
Hill, Deborah Katherine; Kim, Eugene; Teruel, Jose Ramon; Jamin, Yann; Widerøe, Marius; Søgaard, Caroline Danielsen; Størkersen, Øystein; Nava Rodriguez, Daniel; Heindl, Andreas; Yuan, Yinyin; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)Purpose To improve early diagnosis of prostate cancer to aid clinical decision-making. Diffusion-weighted magnetic resonance imaging (DW-MRI) is sensitive to water diffusion throughout tissues, which correlates with ... -
Metabolic Profiling of Prostate Cancer Tissue Using Magnetic Resonance Spectroscopy - An investigation into prostate heterogeneity and cancer characteristics in a transgenic mouse model, with a comparison to human disease
Løveng, Silje (Master thesis, 2017)Using 1H High-Resolution Magic Angle Spinning Magnetic Resonance Spectroscopy, tissue samples of both healthy mouse prostate and different grades of mouse prostate cancer in a transgenic mouse model were analysed to ... -
Metabolic response to everolimus in patient-derived triple negative breast cancer xenografts
Euceda, Leslie R.; Hill, Deborah Katherine; Stokke, Endre; Hatem, Rana; Botty, Rania; Bieche, Ivan; Marangoni, Elisabetta; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2017)Patients with triple-negative breast cancer (TNBC) are unresponsive to endocrine and anti-HER2 pharmacotherapy, limiting their therapeutic options to chemotherapy. TNBC is frequently associated with abnormalities in the ... -
Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model
Hill, Deborah Katherine; Heindl, Andreas; Zormpas-Petridis, Konstantinos; Collins, David J.; Euceda, Leslie R.; Rodrigues, Daniel; Moestue, Siver Andreas; Jamin, Yann; Koh, Dow-Mu; Yuan, Yinyin; Bathen, Tone Frost; Leach, Martin O; Blackledge, Matthew D. (Journal article; Peer reviewed, 2017)Diffusion-weighted magnetic resonance imaging (DWI) enables non-invasive, quantitative staging of prostate cancer via measurement of the apparent diffusion coefficient (ADC) of water within tissues. In cancer, more advanced ... -
Perfusion system for studying dynamic metabolomics in rat brain slices exposed to oxygen–glucose deprivation using proton and phosphorus nuclear magnetic resonance
Molska, Alicja Anna; Hill, Deborah Katherine; Andreassen, Trygve; Widerøe, Marius (Peer reviewed; Journal article, 2022)The aim of the current study was to establish a controlled and reproducible model to study metabolic changes during oxygen–glucose deprivation (OGD) in rat brain using a nuclear magnetic resonance (NMR)-compatible perfusion ... -
Ultrasound and magnetic resonance imaging for group stratification and treatment monitoring in the transgenic adenocarcinoma of the mouse prostate model
Fagerland, Stein-Martin Tilrum; Hill, Deborah Katherine; van Wamel, Annemieke; Davies, Catharina de Lange; Kim, Jana (Journal article; Peer reviewed, 2020)Background:The transgenic adenocarcinoma of the mouse prostate (TRAMP) is a widelyused genetically engineered spontaneous prostate cancer model. However, both thedegree of malignancy and time of cancer onset vary. While ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ...