Browsing NTNU Open by Author "Hertel, Jens Kristoffer"

Now showing items 1-11 of 11

    • Camp-based family treatment of childhood obesity: randomised controlled trial 

      Benestad, Beate; Lekhal, Samira; Småstuen, Milada C; Hertel, Jens Kristoffer; Halsteinli, Vidar; Ødegård, Rønnaug Astri; Hjelmesæth, Jøran (Peer reviewed; Journal article, 2017)
      Objective To compare the effectiveness of a 2-year camp-based family treatment programme and an outpatient programme on obesity in two generations. Design Pragmatic randomised controlled trial. Setting Rehabilitation ...

    • Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range 

      Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida (Journal article; Peer reviewed, 2022)
      Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising ...

    • Effect of Aerobic Exercise Intensity on Energy Expenditure and Weight Loss in Severe Obesity-A Randomized Controlled Trial 

      Berge, Jarle; Hjelmesæth, Jøran; Hertel, Jens Kristoffer; Gjevestad, Espen Svendsen; Småstuen, Milada Cvancarova; Johnson, Line Kristin; Martins, Catia; Andersen, Eivind; Helgerud, Jan; Støren, Øyvind (Peer reviewed; Journal article, 2021)
      Objective This study aimed to compare the effects of two aerobic exercise programs of different intensities on energy expenditure. Methods This was a single‐center randomized controlled trial of patients with severe obesity ...

    • Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial 

      Berge, Jarle; Hjelmesæth, Jøran Sture; Kolotkin, Ronette Loganzo; Støren, Øyvind; Bratland-Sanda, Solfrid; Hertel, Jens Kristoffer; Gjevestad, Espen Svendsen; Småstuen, Milada Cvancarova; Helgerud, Jan; Bernklev, Tomm (Peer reviewed; Journal article, 2022)
      Background Aerobic exercise is an important part of obesity treatment and may improve health-related quality of life (HRQOL). The objective of this study was to compare the effect of two different exercise programs on ...

    • Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study) 

      Hertel, Jens Kristoffer; Johansson, Stefan; Ræder, Helge; Platou, Carl Geoffrey Parrinder; Midthjell, Kristian; Hveem, Kristian; Molven, Anders; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2011)
      Background Chronic hyperglycemia confers increased risk for long-term diabetes-associated complications and repeated hemoglobin A1c (HbA1c) measures are a widely used marker for glycemic control in diabetes treatment ...

    • Health-related quality of life after camp-based family obesity treatment: an RCT 

      Benestad, Beate; Karlsen, Tor-Ivar; Småstuen, Milada Cvancarova; Lekhal, Samira; Hertel, Jens Kristoffer; Steinsbekk, Silje; Kolotkin, Ronette L.; Ødegård, Rønnaug; Hjelmesæth, Jøran (Journal article; Peer reviewed, 2019)
      Objective To compare the effects of a 2-year camp-based immersion family treatment for obesity with an outpatient family-based treatment for obesity on health-related quality of life (HRQoL) in two generations. Design ...

    • Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL) 

      Hjelmesæth, Jøran; Åsberg, Anders; Andersson, Shalini; Sandbu, Rune; Robertsen, Ida; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Hertel, Jens Kristoffer; Skovlund, Eva; Heijer, Maria; Ek, Anna-Lena; Krogstad, Veronica; Karlsen, Tor-Ivar; Christensen, Hege Staaland; Andersson, Tommy B; Karlsson, Cecilia (Journal article; Peer reviewed, 2018)
      Introduction: Roux-en-Y gastric bypass (GBP) is associated with changes in cardiometabolic risk factors and bioavailability of drugs, but whether these changes are induced by calorie restriction, the weight loss or surgery ...

    • Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity 

      Kvitne, Kine Eide; Åsberg, Anders; Johnson, Line Kristin; Wegler, Christine; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia Elisabeth; Andersson, Shalini; Sandbu, Rune; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Hjelmesæth, Jøran Sture; Robertsen, Ida (Peer reviewed; Journal article, 2022)
      Previous studies have not accounted for the close link between type 2 diabetes mellitus (T2DM) and obesity when investigating the impact of T2DM on cytochrome P450 (CYP) activities. The aim was to investigate the effect ...

    • Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity 

      Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin; Kringen, Marianne K.; Hovd, Markus Herberg; Hertel, Jens Kristoffer; Heijer, Maria; Sandbu, Rune; Skovlund, Eva; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran Sture; Åsberg, Anders; Jansson-Löfmark, Rasmus; Christensen, Hege; Robertsen, Ida (Peer reviewed; Journal article, 2022)
      Aim Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and ...

    • The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) 

      Helgeland, Øyvind; Hertel, Jens Kristoffer; Molven, Anders; Ræder, Helge; Platou, Carl Geoffrey Parrinder; Midthjell, Kristian; Hveem, Kristian; Nygård, Ottar; Njølstad, Pål Rasmus; Johansson, Stefan (Journal article; Peer reviewed, 2015)
      Background. Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD).The precise location and number of risk variants have not ...

    • Type 2 diabetes genes : present status and data from Norwegian studies 

      Hertel, Jens Kristoffer; Johansson, Stefan; Midthjell, Kristian; Nygård, Ottar; Njølstad, Pål Rasmus; Molven, Anders (Journal article; Peer reviewed, 2013)
      The worldwide rise in prevalence of type 2 diabetes has led to an intense search for the genetic risk factors of this disease. In type 2 diabetes and other complex disorders, multiple genetic and environmental factors, as ...