Blar i NTNU Open på forfatter "Henriksen, Silje"
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Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors
Han, Jin; Henriksen, Silje; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2016)The present study describes our continuous effort to develop epidermal growth factor receptor (EGFR) inhibitors based on the 6-aryl-pyrrolo[2,3-d]pyrimidin-4-amine scaffold. The activity-ADME space has been evaluated by ... -
Synthesis of 6-Aryl-pyrrolopyrimidines - Effect of ortho Substituents on EGFR Inhibitory Activity
Henriksen, Silje (Master thesis, 2015)The goal of this project was to synthesise new and active epidermal growth factor receptor (EGFR) inhibitors which hopefully can be used in treatment of cancer. Seven new biological active pyrrolopyrimidines have been ...