Browsing NTNU Open by Author "Hellum, Bent Håvard"
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In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport
Hellum, Bent Håvard (Doktoravhandlinger ved NTNU, 1503-8181; 2007:256, Doctoral thesis, 2007)Omsetningen av naturlegemidler og kosttilskudd har økt dramatisk de siste årene, og en økende aksept for urtebruk tilsier at forbruket fortsatt vil øke. Samtidig bruk av naturlegemidler/urter og legemidler forekommer ofte. ... -
Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product
Thu, Ole Kristian Forstrønen; Spigset, Olav; Hellum, Bent Håvard (Journal article; Peer reviewed, 2017)A commercial Rhodiola rosea (R. rosea) product has previously demonstrated CYP2C9 inhibition in humans. The purpose of this study was to provide in vitro inhibitory data for this particular interaction and to classify the ... -
Simultaneous determination of in vitro CYP activities in human microsomes using hops as a CYP trial inhibitor: A method development study
Gustavsen, Marita Helene (Master thesis, 2016)Cytochrome P450 (CYP) constitutes a superfamily of hemeproteins that plays a key role in the metabolism of drugs and other xenobiotics. Xenobiotic interactions are a major reason for druginduced toxicity and multiple drug ...