Browsing NTNU Open by Author "Helland, Arne"
Now showing items 1-10 of 10
-
Comparison of driving simulator performance with real driving after alcohol intake: A randomised, single blind, placebo-controlled, cross-over trial
Helland, Arne; Jenssen, Gunnar Deinboll; Lervåg, Lone-Eirin; Westin, Andreas Austgulen; Moen, Terje; Sakshaug, Kristian; Lydersen, Stian; Mørland, Jørg; Slørdal, Lars (Journal article; Peer reviewed, 2013)The purpose of this study was to establish and validate a driving simulator method for assessing drug effects on driving. To achieve this, we used ethanol as a positive control, and examined whether ethanol affects driving ... -
Driving Simulator Validation for Drug Impairment Research: Results from a randomized, controlled study comparing simulated and test track driving under the influence of ethanol
Helland, Arne (Doctoral theses at NTNU;2016:304, Doctoral thesis, 2016)Kjøresimulatorer brukes blant annet til å undersøke effekten av legemidler og rusmidler på kjøreatferd og trafikkrisiko. Slik anvendelse forutsetter at testene i kjøresimulatoren virkelig måler det samme som ved kjøring ... -
Enantiomeric separation and quantification of citalopram in serum by ultra-high performance supercritical fluid chromatography-tandem mass spectrometry
Hegstad, Solfrid; Havnen, Hilde; Helland, Arne; Falch, Berit Margrethe Hasle; Spigset, Olav (Journal article; Peer reviewed, 2017)A method for enantiomeric separation and quantification of R/S-citalopram in serum was developed and validated using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS). Sample ... -
Establishing Serum Reference Ranges for Antihypertensive Drugs
Rognstad, Stine; Søraas, Camilla Lund; Bergland, Ola Undrum; Høieggen, Aud; Strømmen, Magnus; Helland, Arne; Opdal, Mimi Stokke (Peer reviewed; Journal article, 2020)Background: Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate ... -
EtG/EtS in Serum by UHPLC-MS-MS in Suspected Sexual Assault Cases
Hegstad, Solfrid; Helland, Arne; Hagemann, Cecilie Therese; Spigset, Olav (Journal article; Peer reviewed, 2017)A method including semi-automated extraction of ethyl glucuronide (EtG) and ethyl sulfate (EtS) from serum followed by ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS-MS) has been developed and ... -
Illegalt eller medisinsk amfetamin – hva er inntatt
Frost, Joachim; Helland, Arne; Syrstad, Vigdis Elin Giæver; Aamo, Trond Oskar (Peer reviewed; Journal article, 2022) -
Oxycodone, Morphine, and Fentanyl in Patients with Chronic Pain: Proposal of Dose-Specific Concentration Ranges
Thaulow, Cecilie Hasselø; Helland, Arne; Kongsgaard, Ulf Erik; Høiseth, Gudrun (Peer reviewed; Journal article, 2023)Background: Interpreting opioid concentrations is challenging because of the lack of reference ranges. Therefore, the authors aimed to propose dose-specific concentration ranges in serum for oxycodone, morphine, and ... -
Recurrent malignant ventricular arrhythmias and paresthesia—a mystery revealed as aconitine poisoning: a case report
Mjølstad, Ole Christian; Radtke, Maria Anita; Brodtkorb, Eylert; Edvardsen, Frode; Wenche Rødseth, Brede; Aamo, Trond Oskar; Jacobsen, Dag; Stokke, Mathis Korseberg; Helland, Arne (Peer reviewed; Journal article, 2023)Background: We report a case of a clinical challenge lasting for 12 months, with severe and unresolved clinical features involving several medical disciplines. Case presentation: A 53-year-old Caucasian male, who had been ... -
Serum concentrations of paliperidone after administration of the long-acting injectable formulation
Helland, Arne; Spigset, Olav (Journal article; Peer reviewed, 2017)Background: The pharmacokinetics of long-acting intramuscular paliperidone in a naturalistic setting is not well documented. The objective of this study was to investigate the relationship between dose and serum concentrations ... -
Serum or Plasma for Quantification of Direct Oral Anticoagulants?
Aakerøy, Rachel; Stokes, Charlotte Lorentze; Tomic, Marija; Hegstad, Solfrid; Kristoffersen, Ann-Helen; Ellekjær, Hanne; Schjøtt, Jan Didrik; Spigset, Olav; Helland, Arne (Peer reviewed; Journal article, 2022)Background: Direct oral anticoagulants are increasingly replacing vitamin K antagonists for prevention of stroke in patients with atrial fibrillation, partly owing to the lack of a need for routine monitoring. Therapeutic ...