Blar i NTNU Open på forfatter "Helland, Arne"
-
Comparison of driving simulator performance with real driving after alcohol intake: A randomised, single blind, placebo-controlled, cross-over trial
Helland, Arne; Jenssen, Gunnar Deinboll; Lervåg, Lone-Eirin; Westin, Andreas Austgulen; Moen, Terje; Sakshaug, Kristian; Lydersen, Stian; Mørland, Jørg; Slørdal, Lars (Journal article; Peer reviewed, 2013)The purpose of this study was to establish and validate a driving simulator method for assessing drug effects on driving. To achieve this, we used ethanol as a positive control, and examined whether ethanol affects driving ... -
Direct oral anticoagulant concentrations and adherence in stroke patients
Aakerøy, Rachel; Gynnild, Mari Nordbø; Løfblad, Lena; Dyrkorn, Roar; Ellekjær, Hanne; Lydersen, Stian; Helland, Arne; Spigset, Olav (Journal article; Peer reviewed, 2023)No therapeutic ranges linking drug concentrations of apixaban and rivaroxaban to clinical outcomes have been defined. We investigated whether direct oral anticoagulant (DOAC) concentrations among patients admitted to ... -
Driving Simulator Validation for Drug Impairment Research: Results from a randomized, controlled study comparing simulated and test track driving under the influence of ethanol
Helland, Arne (Doctoral theses at NTNU;2016:304, Doctoral thesis, 2016)Kjøresimulatorer brukes blant annet til å undersøke effekten av legemidler og rusmidler på kjøreatferd og trafikkrisiko. Slik anvendelse forutsetter at testene i kjøresimulatoren virkelig måler det samme som ved kjøring ... -
Enantiomeric separation and quantification of citalopram in serum by ultra-high performance supercritical fluid chromatography-tandem mass spectrometry
Hegstad, Solfrid; Havnen, Hilde; Helland, Arne; Falch, Berit Margrethe Hasle; Spigset, Olav (Journal article; Peer reviewed, 2017)A method for enantiomeric separation and quantification of R/S-citalopram in serum was developed and validated using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS). Sample ... -
Establishing Serum Reference Ranges for Antihypertensive Drugs
Rognstad, Stine; Søraas, Camilla Lund; Bergland, Ola Undrum; Høieggen, Aud; Strømmen, Magnus; Helland, Arne; Opdal, Mimi Stokke (Peer reviewed; Journal article, 2020)Background: Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate ... -
EtG/EtS in Serum by UHPLC-MS-MS in Suspected Sexual Assault Cases
Hegstad, Solfrid; Helland, Arne; Hagemann, Cecilie Therese; Spigset, Olav (Journal article; Peer reviewed, 2017)A method including semi-automated extraction of ethyl glucuronide (EtG) and ethyl sulfate (EtS) from serum followed by ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS-MS) has been developed and ... -
Illegalt eller medisinsk amfetamin – hva er inntatt
Frost, Joachim; Helland, Arne; Syrstad, Vigdis Elin Giæver; Aamo, Trond Oskar (Peer reviewed; Journal article, 2022) -
Oxycodone, Morphine, and Fentanyl in Patients with Chronic Pain: Proposal of Dose-Specific Concentration Ranges
Thaulow, Cecilie Hasselø; Helland, Arne; Kongsgaard, Ulf Erik; Høiseth, Gudrun (Peer reviewed; Journal article, 2023)Background: Interpreting opioid concentrations is challenging because of the lack of reference ranges. Therefore, the authors aimed to propose dose-specific concentration ranges in serum for oxycodone, morphine, and ... -
Recurrent malignant ventricular arrhythmias and paresthesia—a mystery revealed as aconitine poisoning: a case report
Mjølstad, Ole Christian; Radtke, Maria Anita; Brodtkorb, Eylert; Edvardsen, Frode; Wenche Rødseth, Brede; Aamo, Trond Oskar; Jacobsen, Dag; Stokke, Mathis Korseberg; Helland, Arne (Peer reviewed; Journal article, 2023)Background: We report a case of a clinical challenge lasting for 12 months, with severe and unresolved clinical features involving several medical disciplines. Case presentation: A 53-year-old Caucasian male, who had been ... -
Serum concentrations of paliperidone after administration of the long-acting injectable formulation
Helland, Arne; Spigset, Olav (Journal article; Peer reviewed, 2017)Background: The pharmacokinetics of long-acting intramuscular paliperidone in a naturalistic setting is not well documented. The objective of this study was to investigate the relationship between dose and serum concentrations ... -
Serum or Plasma for Quantification of Direct Oral Anticoagulants?
Aakerøy, Rachel; Stokes, Charlotte Lorentze; Tomic, Marija; Hegstad, Solfrid; Kristoffersen, Ann-Helen; Ellekjær, Hanne; Schjøtt, Jan Didrik; Spigset, Olav; Helland, Arne (Peer reviewed; Journal article, 2022)Background: Direct oral anticoagulants are increasingly replacing vitamin K antagonists for prevention of stroke in patients with atrial fibrillation, partly owing to the lack of a need for routine monitoring. Therapeutic ... -
Therapeutic drug monitoring of direct oral anticoagulants - Analytical issues and factors affecting drug concentrations
Aakerøy, Rachel (Doctoral theses at NTNU;2024:425, Doctoral thesis, 2024)Terapeutisk legemiddelmonitorering av direkte orale antikoagulantia: Analytiske forhold og faktorer som påvirker legemiddelkonsentrasjoner. Blodfortynnende legemidler i gruppen direktevirkende orale antikoagulantia (DOAK) ...