• Characteristics of preeclampsia in donor cell gestations 

      Ervaala, Attina; Laivuori, Hannele; Gissler, Mika; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Kajantie, Eero Olavi; Heinonen, Seppo; Wedenoja, Satu (Peer reviewed; Journal article, 2022)
      Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among ...
    • Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia 

      Dijkstra, Douwe Jan; Lokki, A Inkeri; Gierman, Lobke; Borggreven, Nicole Veronique; van der Keur, Carin; Eikmans, Michael; Gelderman, Kyra Andrea; Laivuori, Hannele; Heinonen, Seppo; Kajantie, Eero Olavi; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Iversen, Ann-Charlotte; van der Hoorn, Marie-Louise P; Trouw, Leendert Adrianus (Peer reviewed; Journal article, 2022)
      Preeclampsia (PE) generally manifests in the second half of pregnancy with hypertension and proteinuria. The understanding of the origin and mechanism behind PE is incomplete, although there is clearly an immune component ...
    • External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis 

      Snell, Kym I.E.; Allotey, John; Smuk, Melanie; Hooper, Richard; Chan, Claire; Ahmed, Asif; Chappell, Lucy C.; Von Dadelszen, Peter; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid; Mol, Ben W.; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne Cathrine; Smith, Gordon C.S.; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony; Arenas Ramírez, Javier; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, Ahmet A.; Seed, Paul T.; Prefumo, Federico; da Silva Costa, Fabricio; Groen, Henk; Audibert, Francois; Masse, Jacques; Skråstad, Ragnhild Bergene; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, Chie; Rumbold, Alice R.; Heinonen, Seppo; Askie, Lisa; Smits, Luc; Vinter, Christina; Magnus, Per; Eero, Kajantie; Villa, Pia M.; Jenum, Anne Karen; Andersen, Louise B.; Norman, Jane E.; Ohkuchi, Akihide; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala; Galindo, Alberto; Herraiz, Ignacio; Carbillon, Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Browne, Joyce L.; Moons, Karel G.M.; Riley, Richard D.; Thangaratinam, Shakila (Peer reviewed; Journal article, 2020)
      Background Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk during pregnancy is required to plan management. Although there are many published ...
    • Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia 

      Wedenoja, Satu; Yoshihara, Masahito; Teder, Hindrek; Sariola, Hannu; Gissler, Mika; Katayama, Shintaro; Wedenoja, Juho; Häkkinen, Inka M.; Ezer, Sini; Linder, Nina; Lundin, Johan; Skoog, Tiina; Sahlin, Ellika; Iwarsson, Erik; Pettersson, Karin; Kajantie, Eero Olavi; Mokkonen, Mikael; Heinonen, Seppo; Laivuori, Hannele; Krjutškov, Kaarel; Kere, Juha (Peer reviewed; Journal article, 2020)
      Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other ...
    • Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene 

      Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K (Journal article; Peer reviewed, 2012)
      Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry ...
    • Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis 

      Allotey, John; Snell, Kym I.E.; Smuk, Melanie; Hooper, Richard; Chan, Claire; Ahmed, Asif; Chappell, Lucy C.; von Dadelszen, Peter; Dodds, Julie; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid S.; Mol, Ben W.; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne Cathrine; Smith, Gordon C.S.; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony O.; Ramírez, Javier A.; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, AA; Seed, PT; Prefumo, F; da Silva Costa, F; Groen, H; Audibert, F; Masse, J; Skråstad, Ragnhild Bergene; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, C; Rumbold, Alice R.; Heinonen, Seppo; Askie, LM; Smits, LJ; Vinter, CA; Magnus, Per; Kajantie, Eero Olavi; Villa, PM; Jenum, Anne Karen; Andersen, LB; Norman, JE; Ohkuchi, A; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala M.; Galindo, Alberto; Herraiz, Ignacio; Carbillon, , Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Teede, Helena J.; Browne, Joyce L; Moons, Karel G.M.; Riley, Richard D; Thangaratinam, Shakila (Peer reviewed; Journal article, 2020)
      Background: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk is needed to plan management. Objectives: To assess the performance of existing pre-eclampsia ...