Blar i NTNU Open på forfatter "Hegstad, Solfrid"
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Association between low body weight and cytochrome P-450 enzyme activity in patients with anorexia nervosa
Sandvik, Pål; Lydersen, Stian; Hegstad, Solfrid; Spigset, Olav (Peer reviewed; Journal article, 2020)Very little is known to which extent severe underweight could affect cytochrome P-450 (CYP) enzyme activity. In this study, 24 patients with anorexia nervosa at two occasions ingested single oral doses of five test drugs ... -
Bestemmelse av tuberkulostatika i blod ved LC-MSMS: Litteraturstudie
Axell, Alexander D. Larsen; Fjellanger, Kristin L.; Thorbjørnsen, Helene Ställvik (Bachelor thesis, 2020)Metoder for kvantitering av tuberkulostatika (rifampicin, isoniazid og acetylisoniazid) i blod ved bruk av LC-MSMS har blitt studert. Referanser fra litteraturstudiet er hentet fra databasene Medline og Embase. Søket ble ... -
Conductive vial electromembrane extraction of opioids from oral fluid
Skaalvik, Tonje Gottenberg; Zhou, Chen; Øiestad, Elisabeth Leere; Hegstad, Solfrid; Trones, Roger; Pedersen-Bjergaard, Stig (Peer reviewed; Journal article, 2023)The use of oral fluid as sample matrix has gained significance in the analysis of drugs of abuse due to its non-invasive nature. In this study, the 13 opioids morphine, oxycodone, codeine, O-desmethyl tramadol, ethylmorphine, ... -
Determination of amphetamine enantiomers in urine by conductive vial electromembrane extraction and ultra-high performance supercritical fluid chromatography tandem mass spectrometry
Skaalvik, Tonje Gottenberg; Øiestad, Elisabeth Leere; Pedersen-Bjergaard, Stig; Hegstad, Solfrid (Peer reviewed; Journal article, 2023)Separation and quantification of amphetamine enantiomers are commonly used to distinguish between consumption of prescription amphetamine (mostly S ‐amphetamine) and illicit forms of the drug (racemate). In this study, ... -
Determination of psychoactive drugs in serum using conductive vial electromembrane extraction combined with UHPLC-MS/MS
Skaalvik, Tonje Gottenberg; Øiestad, Elisabeth Leere; Trones, Roger; Pedersen-Bjergaard, Stig; Hegstad, Solfrid (Peer reviewed; Journal article, 2021)Conductive vial electromembrane extraction (EME) with prototype equipment was applied for the first time to extract lipophilic basic drugs from serum. With this equipment, traditional platinum electrodes were replaced with ... -
Enantiomeric separation and quantification of citalopram in serum by ultra-high performance supercritical fluid chromatography-tandem mass spectrometry
Hegstad, Solfrid; Havnen, Hilde; Helland, Arne; Falch, Berit Margrethe Hasle; Spigset, Olav (Journal article; Peer reviewed, 2017)A method for enantiomeric separation and quantification of R/S-citalopram in serum was developed and validated using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS). Sample ... -
EtG and EtS in autopsy blood samples with and without putrefaction using UPLC-MS-MS
Hegstad, Solfrid; Kristoffersen, Lena; Liane, Veronica Horpestad; Spigset, Olav (Journal article; Peer reviewed, 2017)Analytical challenges related to postmortem specimens are well known. The degree of putrefaction of the corpse will influence the quality of the blood samples, and both the efficiency of sample preparation and the subsequent ... -
EtG/EtS in Serum by UHPLC-MS-MS in Suspected Sexual Assault Cases
Hegstad, Solfrid; Helland, Arne; Hagemann, Cecilie Therese; Spigset, Olav (Journal article; Peer reviewed, 2017)A method including semi-automated extraction of ethyl glucuronide (EtG) and ethyl sulfate (EtS) from serum followed by ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS-MS) has been developed and ... -
Serum Concentrations and Pharmacokinetics of Tranexamic Acid after Two Means of Topical Administration in Massive Weight Loss Skin-Reducing Surgery
Ausen, Kjersti; Pleym, Hilde; Liu, Jiayin; Hegstad, Solfrid; Nordgård, Håvard Bersås; Pavlovic, Ivan; Spigset, Olav (Journal article; Peer reviewed, 2019)Background: Topical administration of tranexamic acid to reduce bleeding is receiving increasing attention, as it is inexpensive, simple, and possibly beneficial in most surgery. Concerns regarding potential systemic adverse ... -
Serum or Plasma for Quantification of Direct Oral Anticoagulants?
Aakerøy, Rachel; Stokes, Charlotte Lorentze; Tomic, Marija; Hegstad, Solfrid; Kristoffersen, Ann-Helen; Ellekjær, Hanne; Schjøtt, Jan Didrik; Spigset, Olav; Helland, Arne (Peer reviewed; Journal article, 2022)Background: Direct oral anticoagulants are increasingly replacing vitamin K antagonists for prevention of stroke in patients with atrial fibrillation, partly owing to the lack of a need for routine monitoring. Therapeutic ... -
Validering av analysemetode for amfetaminer, ecstasy-stoffer og ritalinsyre i humant serum med bruk av pipetteringsrobot og UHPLC-MS/MS
Hansen, Miriam (Master thesis, 2018)Sentralstimulerende midler brukes både som illegale rusmidler og til medisinsk bruk. Konsentrasjonsbestemmelse i serum utføres for å avdekke misbruk eller som kontroll i for- bindelse med terapeutisk legemiddelmonitorering. ...