Browsing NTNU Open by Author "Hautakangas, Heidi"

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    • Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor 

      Winsvold, Bendik Kristoffer Slagsvold; Harder, Aster V. E.; Ran, Caroline; Chalmer, Mona A.; Dalmasso, Maria Carolina; Ferkingstad, Egil; Tripathi, Kumar Parijat; Bacchelli, Elena; Børte, Sigrid; Fourier, Carmen; Petersen, Anja S.; Vijfhuizen, Lisanne S.; Magnusson, Sigurdur H.; O'Connor, Emer; Bjornsdottir, Gyda; Häppölä, Paavo; Wang, Yen-Feng; Callesen, Ida; Kelderman, Tim; Gallardo, Victor J; de Boer, Irene; Olofsgård, Felicia Jennysdotter; Heinze, Katja; Lund, Nunu; Thomas, Laurent Francois; Hsu, Chia-Lin; Pirinen, Matti; Hautakangas, Heidi; Ribasés, Marta; Guerzoni, Simona; Sivakumar, Prasanth; Yip, Janice; Heinze, Axel; Küçükali, Fahri; Ostrowski, Sisse R.; Pedersen, Ole B.; Kristoffersen, Espen Saxhaug; Martinsen, Amy; Artigas, María S.; Lagrata, Susie; Cainazzo, Maria Michela; Adebimpe, Joycee; Quinn, Olivia; Göbel, Carl; Cirkel, Anna; Volk, Alexander E.; Heilmann-Heimbach, Stefanie; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Wilbrink, Leopoldine A.; Danno, Daisuke; Mehta, Dwij; Guðbjartsson, Daníel F.; Rosendaal, Frits Richard; Willems van Dijk, Ko; Fronczek, Rolf; Wagner, Michael; Scherer, Martin; Göbel, Hartmut; Sleegers, Kristel; Sveinsson, Olafur A.; Pani, Luca; Zoli, Michele; Ramos-Quiroga, Josep A.; Dardiotis, Efthimios; Steinberg, Anna; Riedel-Heller, Steffi; Sjöstrand, Christina; Thorgeirsson, Thorgeir E.; Stefansson, Hreinn; Southgate, Laura; Trembath, Richard C.; Vandrovcova, Jana; Noordam, Raymond; Paemeleire, Koen; Stefansson, Kari; Fann, Cathy Shen-Jang; Waldenlind, Elisabet; Tronvik, Erling Andreas; Jensen, Rigmor H.; Chen, Shih-Pin; Houlden, Henry; Terwindt, Gisela M.; Kubisch, Christian; Maestrini, Elena; Vikelis, Michail; Pozo-Rosich, Patricia; Belin, Andrea C.; Matharu, Manjit; van den Maagdenberg, Arn M.J.M.; Hansen, Thomas; Ramirez, Alfredo; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2023)
      Objective The objective of this study was to aggregate data for the first genomewide association study meta-analysis of cluster headache, to identify genetic risk variants, and gain biological insights. Methods A ...

    • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles 

      Hautakangas, Heidi; Winsvold, Bendik K S; Ruotsalainen, Sanni; Bjornsdottir, Gyda; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben Michael; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Gabrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke-Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen Saxhaug; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W. J. H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits Richard; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2022)
      Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ...

    • HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study 

      Qu, Kang; Li, Ming-Xi; Yu, Peng; Palotie, Aarno; Pressman, Alice; Belin, Andrea C.; Bjornsdottir, Anna; van den Maagdenberg, Arn M. J. M.; Harder, Aster V. E.; Winsvold, Bendik Kristoffer Slagsvold; Müller-Myhsok, Bertram; Cormand, Bru; Ran, Caroline; Northover, Carrie; Kubisch, Christian; van Duijn, Cornelia; Nyholt, Dale R.; Chasman, Daniel I.; Posthuma, Danielle; Lessel, Davor; Boomsma, Dorret I.; Hämäläinen, Eija; Kristoffersen, Espen Saxhaug; Cuenca-Leon, Ester; Davey-Smith, George; Terwindt, Gisela M.; Sigurdardottir, Gudrun R.; Bjornsdottir, Gyda; Hautakangas, Heidi; Stefansson, Hreinn; de Boer, Irene; Kaprio, Jaakko; Olesen, Jes; Zwart, John Anker Henrik; Stefansson, Kari; Ligthart, Lannie; Launer, Lenore; Pedersen, Linda Margareth; Kogelman, Lisette J. A.; Griffiths, Lyn R.; Ikram, M. Arfan; Wessman, Maija; Kaunisto, Mari; Hrafnsdottir, Maria G.; Hiekkala, Marjo; Järvelin, Marjo-Riitta; Dichgans, Martin; Pirinen, Matti; Kallela, Mikko; Kurki, Mitja; Chalmer, Mona A.; Pedersen, Nancy; Sveinsson, Olafur A.; Raitakari, Olli; Gormley, Padhraig; Pozo-Rosich, Patricia; Palta, Priit; Malik, Rainer; Kajanne, Risto; Børte, Sigrid; Magnusson, Sigurdur H.; Lehtimäki, Terho; Hansen, Thomas F; Thorgeirsson, Thorgeir E.; Freilinger, Tobias; Kurth, Tobias; Esko, Tonu; Anttila, Verneri; Artto, Ville; Wu, Bai-Hua; Shi, Miao; Dong, Ming (Peer reviewed; Journal article, 2024)
      Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We used four types of genetic ...