Browsing NTNU Open by Author "Hanssen-Bauer, Audun"
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An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells
Sousa, Mirta; Zub, Kamila Anna; Aas, Per Arne; Hanssen-Bauer, Audun; Demirovic, Aida; Sarno, Antonio; Tian, Erming; Liabakk, Nina-Beate; Slupphaug, Geir (Journal article; Peer reviewed, 2013)Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 ... -
P38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage
Sousa, Mirta; Bjørås, Karine; Hanssen-Bauer, Audun; Solvang-Garten, Karin; Otterlei, Marit (Journal article; Peer reviewed, 2017)XRCC1 is a scaffold protein involved in base excision repair and single strand break repair. It is a phosphoprotein that contains more than 45 phosphorylation sites, however only a few of these have been characterized and ... -
X-ray repair cross complementing protein 1 in base excision repair
Hanssen-Bauer, Audun; Solvang-Garten, Karin; Akbari, Mansour; Otterlei, Marit (Journal article; Peer reviewed, 2012)X-ray Repair Cross Complementing protein 1 (XRCC1) acts as a scaffolding protein in the converging base excision repair (BER) and single strand break repair (SSBR) pathways. XRCC1 also interacts with itself and rapidly ... -
X-ray repair cross-complementing protein 1 associated multiprotein complexes in base excision repair
Hanssen-Bauer, Audun (Doktoravhandlinger ved NTNU, 1503-8181; 2012:116, Doctoral thesis, 2012)XRCC1 assoierte multiproteinkomplekser i base eksisjonsreparasjon Arvestoffet (DNA) degraderes konstant av ytre faktorer, som stråling og kjemikalier, og indre faktorer, som produkter av metabolismen. Slik degradering ...