• Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy 

      Suica, Viorel I.; Uyy, Elena; Ivan, Luminita; Boteanu, Raluca M.; Cerveanu-Hogas, Aurel; Hansen, Rune; Antohe, Felicia (Peer reviewed; Journal article, 2022)
      Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of ...
    • Dual-frequency Transducers for Ultrasound Imaging and Therapy 

      Myhre, Ola Finneng (Doctoral theses at NTNU;2017:206, Doctoral thesis, 2017)
      Chemotherapy is a widely used treatment option for managing cancer disease. It is a systemically administered treatment, meaning that when applied, it affects the whole body. Only a small fraction of the drug reaches the ...
    • Effect of acoustic radiation force on displacement of nanoparticles in collagen gels 

      Løvmo, Mia Kvåle; Yemane, Petros Tesfamichael; Bjørkøy, Astrid; Hansen, Rune; Cleveland, Robin O.; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)
      Penetration of nanoscale therapeutic agents into the extracellular matrix (ECM) of a tumor is a limiting factor for the sufficient delivery of drugs in tumors. Ultrasound (US) in combination with microbubbles causing ...
    • Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time 

      Yemane, Petros Tesfamichael; Åslund, Andreas K. O.; Snipstad, Sofie; Bjørkøy, Astrid; Grendstad, Kristin; Berg, Sigrid; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Hansen, Rune; Davies, Catharina de Lange (Journal article; Peer reviewed, 2019)
      Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect ...
    • Estimation of nonlinear bulk elasticity parameter for cancer tumors 

      Helgedagsrud, Hanne Maren (Master thesis, 2021)
      Tofrekvens-ultralyd har blitt brukt til å estimere ikke-lineær bulk elastisitet for adenokarsinom i bukspyttkjertelen (PDAC svulst), den vanligste krefttypen i bukspyttkjertelen. Svulstene har vokst i KPC-mus, men målingene ...
    • Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery 

      Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild; Snipstad, Sofie; Murvold, Elsa Thodesen; Jouleh, Tæraneh; Berg, Sigrid; Hansen, Rune; Popa, Mihaela-Lucia; Mccormack, Emmet Matin; Gilja, Odd Helge; Poortinga, Albert (Peer reviewed; Journal article, 2022)
      The aim of this study was to develop high load-capacity antibubbles that can be visualized using diagnostic ultrasound and the encapsulated drug can be released and delivered using clinically translatable ultrasound. The ...
    • Hepatic Alarmins and Mitochondrial Dysfunction under Residual Hyperlipidemic Stress Lead to Irreversible NAFLD 

      Ivan, Luminita; Uyy, Elena; Suica, Viorel; Boteanu, Raluca; Cerveanu-Hogas, Aurel; Hansen, Rune; Antohe, Felicia (Peer reviewed; Journal article, 2022)
      Background and Aims Nonalcoholic fatty liver disease (NAFLD) includes a range of progressive disorders generated by excess lipid accumulation in the liver leading to hepatic steatosis and eventually fibrosis. We aimed ...
    • Intravascular Targets for Molecular Contrast-Enhanced Ultrasound Imaging 

      Moestue, Siver Andreas; Gribbestad, Ingrid S; Hansen, Rune (Journal article; Peer reviewed, 2012)
      Molecular targeting of contrast agents for ultrasound imaging is emerging as a new medical imaging modality. It combines advances in ultrasound technology with principles of molecular imaging, thereby allowing non-invasive ...
    • Multimodal Phantom of Liver Tissue 

      Chmarra, Magdalena Karolina; Hansen, Rune; Mårvik, Ronald; Langø, Thomas (Journal article; Peer reviewed, 2013)
      Medical imaging plays an important role in patients' care and is continuously being used in managing health and disease. To obtain the maximum benefit from this rapidly developing technology, further research is needed. ...
    • Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles 

      Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)
      The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ...
    • Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound 

      Einen, Caroline; Price, Sebastian Everard Nordby; Ulvik, Kim; Gjennestad, Magnus Aashammer; Hansen, Rune; Kjelstrup, Signe; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)
      Pulsed focused ultrasound (FUS) in combination with microbubbles has been shown to improve delivery and penetration of nanoparticles in tumors. To understand the mechanisms behind this treatment, it is important to evaluate ...
    • Nanoparticle uptake by brain endothelial cells and focused ultrasound-mediated transport across the blood-brain barrier 

      Baghirov, Habib (Doctoral theses at NTNU;2017:3, Doctoral thesis, 2016)
      More and more people in the world suffer from various brain diseases such as Parkinson’s disease, Alzheimer’s disease and brain cancer. One of the reasons it is so difficult to treat them is the blood-brain barrier (BBB) ...
    • Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery 

      Mørch, Ýrr Asbjørg; Hansen, Rune; Berg, Sigrid; Åslund, Andreas; Glomm, Wilhelm; Eggen, Siv; Schmid, Ruth; Johnsen, Heidi; Kubowicz, Stephan; Snipstad, Sofie; Sulheim, Einar; Hak, Sjoerd; Singh, Gurvinder; McDonagh, Birgitte Hjelmeland; Blom, Hans; Davies, Ruth Catharina de Lange; Stenstad, Per Martin (Journal article, 2015)
      Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ...
    • Regulated cell death joins in atherosclerotic plaque silent progression 

      Uyy, Elena; Suica, Viorel I.; Boteanu, Raluca M.; Cerveanu-Hogas, Aurel; Ivan, Luminita; Hansen, Rune; Antohe, Felicia (Peer reviewed; Journal article, 2022)
      Non-apoptotic regulated cell death (ferroptosis and necroptosis) leads to the release of damage-associated molecular patterns (DAMPs), which initiate and perpetuate a non-infectious inflammatory response. We hypothesize ...
    • Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel 

      Snipstad, Sofie; Mørch, Ýrr; Sulheim, Einar; Åslund, Andreas; Pedersen, André; Hansen, Rune; Davies, Catharina de Lange; Berg, Sigrid (Peer reviewed; Journal article, 2021)
      Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ...
    • The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy 

      Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)
      Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ...
    • Transmit Beams Adapted to Reverberation Noise Suppression Using Dual-Frequency SURF Imaging 

      Näsholm, Sven Peter; Hansen, Rune; Måsøy, Svein-Erik; Johansen, Tonni Franke; Angelsen, Bjørn Atle J. (Peer reviewed; Journal article, 2009)
      A method that uses dual-frequency pulse complexes of widely separated frequency bands to suppress noise caused by multiple scattering or multiple reflections in medical ultrasound imaging is presented. The excitation pulse ...
    • Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation 

      van Wamel, Annemieke; Mühlenpfordt, Melina; Hansen, Rune; Healey, Andrew; Villanueva, Flordeliza S.; Kotopoulis, Spiros; Davies, Catharina de Lange; Chen, Xucai (Peer reviewed; Journal article, 2022)
      Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ...
    • Ultrasound for the delivery of a nanocarrier across biological barriers in tumors: impact of cavitation and acoustic radiation force 

      Yemane, Petros Tesfamichael (Doctoral theses at NTNU;2020:56, Doctoral thesis, 2020)
      Ultrasound for the delivery of a nanocarrier across biological barriers in tumors: impact of cavitation and acoustic radiation force Although conventional chemotherapy is the still one of the most important treatment ...
    • Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts 

      Snipstad, Sofie; Berg, Sigrid; Mørch, Ýrr Asbjørg; Bjørkøy, Astrid; Sulheim, Einar; Hansen, Rune; Grimstad, Ingeborg; van Wamel, Annemieke; Maaland, Astri Fjelde; Torp, Sverre Helge; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)
      Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ...