• Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids 

      Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Peer reviewed, 2023)
    • Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M 

      Hansen, Marianne Dore; Johnsen, Ingvild Bjellmo; Stiberg, Kim Andre Ha; Sherstova, Tatyana; Wakita, Takaji; Richard, Gabriel Mary; Kandasamy, Richard Kumaran; Meurs, Eliane F.; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2017)
      Positive-stranded RNA viruses, such as hepatitis C virus (HCV), assemble their viral replication complexes by remodeling host intracellular membranes to a membranous web. The precise composition of these replication complexes ...
    • Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis 

      Bruland, Torunn; Østvik, Ann Elisabet; Sandvik, Arne Kristian; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)
      Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and ...
    • The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the golgi apparatus during hepatitis C virus infection 

      Daussy, Coralie F.; Monard, Sarah C.; Guy, Coralie; Muñoz-González, Sara; Chazal, Maxime; Anthonsen, Marit Walbye; Jouvenet, Nolwenn; Henry, Thomas; Dreux, Marlène; Meurs, Eliane F.; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)
      Hepatitis C virus (HCV) infection triggers Golgi fragmentation through the Golgi-resident protein immunity-related GTPase M (IRGM). Here, we report the roles of NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) and ...
    • Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT 

      Dabo, Stephanie; Maillard, Patrick; Rodriguez, Milagros Collados; Hansen, Marianne Dore; Mazouz, Sabrina; Bigot, Donna-Joe; Tible, Marion; Janvier, Geneviève; Helynck, Oliver; Cassonnet, Patricia; Jacob, Yves; Bellalou, Jacques; Gatignol, Anne; Patel, Rekha C; Hugon, Jacques; Munier-Lehmann, Hélène; Meurs, Eliane F. (Journal article; Peer reviewed, 2017)
      PKR is a cellular kinase involved in the regulation of the integrative stress response (ISR) and pro-inflammatory pathways. Two N-terminal dsRNA Binding Domains (DRBD) are required for activation of PKR, by interaction ...
    • Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium 

      Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2022)
      Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory ...