Browsing NTNU Open by Author "Hammarström, Per"

Now showing items 1-9 of 9

    • ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype 

      Caesar, Ina; Nilsson, K. Peter R.; Hammarström, Per; Lindgren, Olof Mikael; Prokop, Stefan; Heppner, Frank L.; Schmeidler, James; Haroutunian, Vahram; Holtzman, David M.; Hof, Patrick R.; Gandy, Sam (Peer reviewed; Journal article, 2023)
      Background: The apolipoprotein E (APOE, gene; apoE, protein) ε4 allele is the most commonly identified genetic risk factor for typical late-onset sporadic Alzheimer’s disease (AD). Each APOE ε4 allele roughly triples the ...

    • Contrast Enhanced Magnetic Resonance Imaging of Amyloid-β Plaques in a Murine Alzheimer's Disease Model 

      Sulheim, Einar; Widerøe, Marius; Bäck, Marcus; Nilsson, K Peter R; Hammarström, Per; Nilsson, Lars; Davies, Catharina de Lange; Åslund, Karl Olof Andreas (Journal article; Peer reviewed, 2023)
      Background: Early detection of amyloid-β (Aβ) aggregates is a critical step to improve the treatment of Alzheimer’s disease (AD) because neuronal damage by the Aβ aggregates occurs before clinical symptoms are apparent. ...

    • In Vitro Cell Model Investigation of Alpha-Synuclein Aggregate Morphology Using Spectroscopic Imaging 

      Swaminathan, Priyanka; Klingstedt, Therése; Theologidis, Vasileios; Gram, Hjalte; Larsson, Johan; Hagen, Lars; Liabakk, Nina-Beate; Gederaas, Odrun Arna; Hammarström, Per; Nilsson, K. Peter R.; Van Den Berge, Nathalie; Lindgren, Mikael (Peer reviewed; Journal article, 2024)
      Recently, it has been hypothesized that alpha-synuclein protein strain morphology may be associated with clinical subtypes of alpha-synucleinopathies, like Parkinson’s disease and multiple system atrophy. However, direct ...

    • Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity† 

      Yuzu, Keisuke; Lindgren, Mikael; Nyström, Sofie; Zhang, Jun; Mori, Wakako; Kunitomi, Risako; Nagase, Terumasa; Iwaya, Keiichi; Hammarström, Per; Zako, Tamotsu (Peer reviewed; Journal article, 2020)
      Amyloid specific fluorescent probes are becoming an important tool for studies of disease progression and conformational polymorphisms in diseases related to protein misfolding and aggregation such as localized and systemic ...

    • Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation 

      Psonka-Antonczyk, Katarzyna Maria; Hammarström, Per; Johansson, Leif B. G.; Lindgren, Mikael; Stokke, Bjørn Torger; Nilsson, K. Peter R.; Nyström, Sofie (Peer reviewed; Journal article, 2016)
      Amyloid plaques composed of fibrillar Amyloid-β (Aβ) are hallmarks of Alzheimer's disease. However, Aβ fibrils are morphologically heterogeneous. Conformation sensitive luminescent conjugated oligothiophenes (LCOs) are ...

    • Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States 

      Psonka-Antonczyk, Katarzyna Maria; Duboisset, Julien; Stokke, Bjørn Torger; Zako, Tamotsu; Kobayashi, Takahiro; Maeda, Mizuo; Nyström, Sofie; Mason, Jeffrey; Hammarström, Per; Nilsson, K. Peter R.; Lindgren, Mikael (Journal article; Peer reviewed, 2012)
      Two different conformational isoforms or amyloid strains of insulin with different cytotoxic capacity have been described previously. Herein these filamentous and fibrillar amyloid states of insulin were investigated using ...

    • Some Fluorescent Ligands for Studying Amyloid Uptake in Human Cell Models 

      Sundnes, Marikken Lærum (Master thesis, 2023)
      Det er økende forekomst av patologier kjennetegnet av amyloidose, der proteiner feilfoldes til giftige, uløselige aggregater kjent som amyloider. Et slikt misfoldende protein er transportproteinet Transthyretin (TTR), som ...

    • trans-Stilbenoids with Extended Fluorescence Lifetimes for the Characterization of Amyloid Fibrils 

      Zhang, Jun; Sandberg, Alexander; Wu, Xiongyu; Nyström, Sofie; Lindgren, Mikael; Konradsson, Peter; Hammarström, Per (Journal article; Peer reviewed, 2017)
      It was previously reported that two naphthyl-based trans-stilbene probes, (E)-4-(2-(naphthalen-1-yl)vinyl)benzene-1,2-diol (1) and (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol (3), can bind to both native transthyretin ...

    • Tyrosine Side-Chain Functionalities at Distinct Positions Determine the Chirooptical Properties and Supramolecular Structures of Pentameric Oligothiophenes 

      Bäck, Marcus; Selegård, Robert; Todarwal, Yogesh; Nyström, Sofie; Norman, Patrick; Linares, Mathieu; Hammarström, Per; Lindgren, Mikael; Nilsson, K. Peter R. (Peer reviewed; Journal article, 2020)
      Control over the photophysical properties and molecular organization of π-conjugated oligothiophenes is essential to their use in organic electronics. Herein we synthesized and characterized a variety of anionic pentameric ...