Browsing NTNU Open by Author "Hamilton, Brett R."

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    • A Versatile and Robust Serine Protease Inhibitor Scaffold from Actinia tenebrosa 

      Chen, Xingchen; Leahy, Darren; Van Haeften, Jessica; Hartfield, Perry; Prentis, Peter J.; van der Burg, Chloé; Surm, Joachim M.; Pavasovic, Ana; Madio, Bruno; Hamilton, Brett R.; King, Glenn F.; Undheim, Eivind Andreas Baste; Brattsand, Maria; Harris, Jonathan M. (Journal article; Peer reviewed, 2019)
      Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for ...

    • Mapping enzyme activity on tissue by functional mass spectrometry imaging 

      Hamilton, Brett R.; Marshall, David L.; Casewell, Nicholas R.; Harrison, Robert A.; Blanksby, Stephen J.; Undheim, Eivind Andreas Baste (Peer reviewed; Journal article, 2019)
      Enzymes are central components of most physiological processes, and are consequently implicated in various pathologies. High‐resolution maps of enzyme activity within tissues therefore represent powerful tools for elucidating ...