• A Complex Interaction between Rickettsia conorii and Dickkopf-1 - Potential Role in Immune Evasion Mechanisms in Endothelial Cells 

      Astrup, Elisabeth; Lekva, Tove; Davi, Giovanni; Otterdal, Kari; Santilli, Francesca; Øie, Erik; Halvorsen, Bente; Damås, Jan Kristian; Raoult, Didier; Vitale, Giustina; Olano, Juan P; Ueland, Thor; Aukrust, Pål (Journal article; Peer reviewed, 2012)
      The pathophysiological hallmark of spotted fever group rickettsioses comprises vascular inflammation. Based on the emerging importance of the wingless (Wnt) pathways in inflammation and vascular biology, we hypothesized ...
    • Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction 

      Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud; Alfsnes, Katrine; Øgaard, Jonas; Rashidi, Azita; Skulberg, Vidar Magne; Yang, Mingyi; Fonseca, Davi de Miranda; Sharma, Animesh; Aronsen, Jan Magnus; Schrumpf, Elisabeth; Ahmed, Muhammad Shakil; Dahl, Christen Peder; Nyman, Tuula Anneli; Ueland, Thor; Melum, Espen; Halvorsen, Bente; Bjørås, Magnar; Attramadal, Håvard; Sjaastad, Ivar; Aukrust, Pål; Yndestad, Arne (Peer reviewed; Journal article, 2020)
      An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function ...
    • The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure 

      Shahini, Negar; Bjørkelund, Elisabeth; Bendz, Christina; Massey, Richard J; Schjalm, Camilla; Halvorsen, Bente; Broch, Kaspar; Ueland, Thor; Gullestad, Lars; Nilsson, Per H.; Aukrust, Pål; Mollnes, Tom Eirik; Louwe, Maria Cornelia (Journal article; Peer reviewed, 2021)
      Objective Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase ...
    • Atrial fibrillation in cryptogenic stroke and TIA patients in the nordic atrial fibrillation and stroke The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Main results 

      Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Al-Ani, R.; Arntzen, Kathrine Grønning; Bakkejord, G.K.; Bekkeseth, H.M.O.; Bjerkeli, Vigdis; Eldøen, Guttorm; Gulsvik, Anne Kristine; Halvorsen, Bente; Høie, G.A.; Ihle-Hansen, Håkon; Ihle-Hansen, Hege; Ingebrigtsen, S.; Johansen, H; Kremer, C.; Krogseth, S.B.; Kruuse, C.; Kurz, Friedrich Martin Wilhelm; Nakstad, Ingvild; Novotny, Vojtech; Næss, Halvor; Qazi, Rehman Ul-Haq; Rezaj, M.K.; Rørholt, Dag Marius Nitschke; Steffensen, Linn Hofsøy; Sømark, Jesper; Tobro, Håkon; Truelsen, T.C.; Wassvik, L.; Ægidius, K.L.; Atar, Dan; Aamodt, Anne Hege (Peer reviewed; Journal article, 2022)
      Introduction: Secondary stroke prevention depends on proper identification of the underlying etiology and initiation of optimal treatment after the index event. The aim of the NOR-FIB study was to detect and quantify ...
    • Atrial fibrillation in cryptogenic stroke and transient ischaemic attack – The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and design 

      Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Johansen, Henriette; Halvorsen, Bente; Bjerkeli, Vigdis; Russell, David; Sandset, Else Charlotte; Ihle-Hansen, Hege; Eriksen, Erik; Næss, Halvor; Novotny, Vojtech; Khanevski, Andrej; Truelsen, Thomas; Idicula, Titto; Ægidius, Karen L.; Tobro, Håkon; Bohne Krogseth, Siv; Ihle-Hansen, Håkon; Hagberg, Guri; Kruuse, Christina; Arntzen, Kathrine; Bakkejord, Grete K.; Villseth, Maja; Nakstad, Ingvild; Eldøen, Guttorm; Shafiq, Raheel; Gulsvik, Anne Kristine; Kurz, Martin; Rezai, Mehdi; Sømark, Jesper; Tingvoll, Stein-Helge; Jonassen, Christine M; Ingebrigtsen, Susanne; Steffensen, Linn Hofsøy; Kremer, Christine; Atar, Dan; Aamodt, Anne Hege (Journal article; Peer reviewed, 2019)
      Purpose Paroxysmal atrial fibrillation is often suspected as a probable cause of cryptogenic stroke. Continuous long-term ECG monitoring using insertable cardiac monitors is a clinically effective technique to screen for ...
    • Cholesterol crystals activate the lectin complement pathway via ficolin-2 and mannose-binding lectin: Implications for the progression of atherosclerosis 

      Pilely, Katrine; Rosbjerg, Anne; Genster, Ninette; Gál, Peter; Pál, Gábor; Halvorsen, Bente; Holm, Sverre; Aukrust, Pål; Bakke, Siril Skaret; Sporsheim, Bjørnar; Nervik, Ingunn; Niyonzima, Nathalie; Bartels, Emil D.; Stahl, Gregory L.; Mollnes, Tom Eirik; Espevik, Terje; Garred, Peter (Journal article, 2016)
      Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown. We hypothesized ...
    • Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor 

      Gravastrand, Caroline S.; Steinkjer, Bjørg; Halvorsen, Bente; Landsem, Anne; Skjelland, Mona; Jacobsen, Eva Astrid; Woodruff, Trent M.; Lambris, John D.; Mollnes, Tom Eirik; Brekke, Ole-Lars; Espevik, Terje; Rokstad, Anne Mari (Journal article; Peer reviewed, 2019)
      Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we ...
    • Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis 

      Niyonzima, Nathalie; Bakke, Siril S.; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang; Sporsheim, Bjørnar; Ryan, Liv; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Skjelland, Mona; Sørensen, Kirsten; Rokstad, Anne Mari A.; Yndestad, Arne; Latz, Eicke; Gullestad, Lars; Andersen, Geir Øystein; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Halvorsen, Bente; Espevik, Terje (Peer reviewed; Journal article, 2020)
      Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ...
    • Complement activation by cholesterol crystals triggers a subsequent cytokine response 

      Niyonzima, Nathalie; Halvorsen, Bente; Sporsheim, Bjørnar; Garred, Peter; Aukrust, Pål; Mollnes, Tom Eirik; Espevik, Terje (Journal article; Peer reviewed, 2017)
      In the host a diverse collection of endogenous danger signals is constantly generated consisting of waste material as protein aggregates or crystalline materials that are recognized and handled by soluble pattern recognition ...
    • Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming 

      Zimmer, Sebastian; Grebe, Alena; Bakke, Siril Skaret; Bode, Niklas; Halvorsen, Bente; Ulas, Thomas; Skjelland, Mona; De Nardo, Dominic; Labzin, Larisa I.; Kerksiek, Anja; Hempel, Chris; Heneka, Michael T.; Hawxhurst, Victoria; Fitzgerald, Michael L.; Trebicka, Jonel; Björkhem, Ingemar; Gustafsson, Jan Åke; Westerterp, Marit; Tall, Alan R.; Wright, Samuel D.; Espevik, Terje; Schultze, Joachim L.; Nickenig, Georg; Lütjohann, Dieter; Latz, Eicke (Journal article, 2016)
      Atherosclerosis is an inflammatory disease linked to elevated blood cholesterol concentrations. Despite ongoing advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains the leading cause ...
    • Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation 

      Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article, 2017)
      Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ...
    • Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation 

      Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article; Peer reviewed, 2017)
      Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ...
    • Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab 

      Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar; Tøllefsen, Ingvild Maria; Ryan, Liv; Bendz, Bjørn; Hopp, Einar; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Andersen, Geir Øystein; Gullestad, Lars; Wiseth, Rune; Amundsen, Brage H.; Damås, Jan Kristian; Kleveland, Ola (Peer reviewed; Journal article, 2023)
      Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab ...
    • Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma 

      Kong, Xiang Yi; Vik, Erik Sebastian; Nawaz, Meh Sameen; Berges, Natalia; Dahl, Tuva Børresdatter; Vågbø, Cathrine; Suganthan, Rajikala; Segers, Filip; Holm, Sverre; Quiles-Jimenez, Ana; Gregersen, Ida; Fladeby, Cathrine; Aukrust, Pål; Bjørås, Magnar; Klungland, Arne; Halvorsen, Bente; Alseth, Ingrun (Peer reviewed; Journal article, 2020)
      Endonuclease V (EndoV) is a conserved inosine-specific ribonuclease with unknown biological function. Here, we present the first mouse model lacking EndoV, which is viable without visible abnormalities. We show that ...
    • DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development 

      Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi; Yang, Kuan; Kong, Xiang Yi; Lauritzen, Knut Husø; Olsen, Maria Belland; Karlsen, Tom Rune; Nyman, Tuula Anneli; Sagen, Ellen Lund; Bjerkeli, Vigdis; Suganthan, Rajikala; Nygård, Ståle; Scheffler, Katja; Prins, Jurriën; Van der Veer, Eric; Øgaard, Jonas; Fløisand, Yngvar; Jørgensen, Helle F.; Holven, Kirsten Bjørklund; Biessen, Erik A.L.; Nilsen, Hilde; Dahl, Tuva Børresdatter; Holm, Sverre; Bennett, Martin R.; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente (Peer reviewed; Journal article, 2021)
      Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ...
    • DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients 

      Olsen, Maria Belland; Huse, Camilla; Sousa, Mirta; Murphy, Sarah Louise Mikalsen; Sarno, Antonio; Obermann, Tobias Sebastian; Yang, Kuan; Holter, Jan Cato; Jørgensen, Marthe Jøntvedt; Christensen, Erik Egeland; Wang, Wei; Ji, Ping; Heggelund, Lars; Hoel, Hedda; Dyrhol-Riise, Anne Ma; Gregersen, Ida; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)
      Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ...
    • Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses 

      Kaarbø, Mari; Yang, Mingyi; Hov, Johannes Espolin Roksund; Holm, Kristian; Sousa, Mirta; Macpherson, Magnhild Eide; Reims, Henrik Mikael; Kran, Anne-Marte Bakken; Halvorsen, Bente; Karlsen, Tom Hemming; Aukrust, Pål; Lundin, Knut; Fevang, Børre; Bjørås, Magnar; Jørgensen, Silje Fjellgård (Peer reviewed; Journal article, 2022)
      Background A substantial proportion of common variable immunodeficiency (CVID) patients has duodenal inflammation of largely unknown etiology. However, because of its histologic similarities with celiac disease, gluten ...
    • Elevated plasma sTIM-3 levels in patients with severe COVID-19 

      Ueland, Thor; Heggelund, Lars; Lind, Andreas; Holten, Aleksander Rygh; Tonby, Kristian; Michelsen, Annika; Jenum, Synne; Jørgensen, Marthe Jøntvedt; Barratt-Due, Andreas; Skeie, Linda Gail; Nordøy, Ingvild; Aanensen Fraz, Mai Sasaki; Paulsen, Else Quist; Pischke, Soeren; Johal, Simreen Kaur; Hesstvedt, Liv; Bogen, Mette; Fevang, Børre; Halvorsen, Bente; Müller, Fredrik; Bekken, Gry Kloumann; Mollnes, Tom Eirik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma; Holter, Jan Cato (Peer reviewed; Journal article, 2020)
      Background The pathogenesis of coronavirus disease 2019 (COVID-19) is still incompletely understood, but it seems to involve immune activation and immune dysregulation. Objective We examined the parameters of activation ...
    • Endonuclease v regulates atherosclerosis through c-c motif chemokine ligand 2-mediated monocyte infiltration 

      Kong, Xiang Yi; Huse, Camilla; Yang, Kuan; Øgaard, Jonas; Jimenez, Natalia Berges; Vik, Erik Sebastian; Nawaz, Meh Sameen; Quiles-Jiménez, Ana M T; Abbas, Azhar; Gregersen, Ida; Holm, Sverre; Bjerkli, Vigdis; Rashidi, Azita; Fladeby, Cathrine; Suganthan, Rajikala; Sagen, Ellen Lund; Skjelland, Mona; Lång, Anna; Bøe, Stig Ove; Bjørås, Magnar; Aukrust, Pål; Alseth, Ingrun; Halvorsen, Bente; Dahl, Tuva Børresdatter (Journal article; Peer reviewed, 2021)
      Background In cardiovascular diseases, atherosclerotic disorder are the most frequent and important with respect to morbidity and mortality. Inflammation mediated by immune cells is central in all parts of the atherosclerotic ...
    • Epitranscriptome in Ischemic Cardiovascular Disease: Potential Target for Therapies 

      Quiles-Jiménez, Ana M T; Dahl, Tuva Børresdatter; Bjørås, Magnar; Alseth, Ingrun; Halvorsen, Bente; Gregersen, Ida (Journal article; Peer reviewed, 2022)