Browsing NTNU Open by Author "Hals, Ingrid Katrin"

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Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia

Hals, Ingrid Katrin; Rokstad, Anne Mari; Strand, Berit Løkensgard; Oberholzer, José; Grill, Valdemar (Journal article; Peer reviewed, 2013)

Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ...
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia

Hals, Ingrid Katrin; Bruerberg, Simon Gustafson; Ma, Zuheng; Scholz, Hanne; Björklund, Anneli; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2015)

Objective: To provide novel insights on mitochondrial respiration in β-cells and the adaptive effects of hypoxia. Methods and Design Insulin-producing INS-1 832/13 cells were exposed to 18 hours of hypoxia followed by ...
Preconditioning with Associated Blocking of Ca2+ Inflow Alleviates Hypoxia-Induced Damage to Pancreatic β-Cells

Ma, ZH; Moruzzi, N; Catrina, SB; Hals, Ingrid Katrin; Oberholzer, J.; Grill, Valdemar; Björklund, A. (Journal article; Peer reviewed, 2013)

Objective: Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact ...