Browsing NTNU Open by Author "Hals, Ingrid Kathrin"
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A 1-year pilot study of intralymphatic injections of GAD-alum in individuals with latent autoimmune diabetes in adults (LADA) with signs of high immunity: No safety concerns and resemblance to juvenile type 1 diabetes
Hals, Ingrid Kathrin; Balasuriya, Chandima Nirupa Dilruks; Casas, Rosaura; Ludvigsson, Johnny; Björklund, Anneli; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2023)Aims To test, for the first time in latent autoimmune diabetes in adults (LADA), the effects of autoantigen-specific immunotherapy by intralymphatic administration of aluminium-formulated recombinant human glutamic acid ... -
Effekter av ketoner og hyperglykemi på mitokondriell funksjon i insulinproduserende β-celler under diabetes-lignende forhold in vitro
Bjørkvik, Astrid (Master thesis, 2021)Bakgrunn: Kronisk hyperglykemi, også kalt "glukotoksisitet", aktiverer ulike signalveier som har skadelige effekter på β-cellenes funksjon og overlevelse. Dette bidrar videre til utvikling av diabetes og både mikro- og ... -
Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates
Hals, Ingrid Kathrin; Ohki, Tsuyoshi; Singh, Rinku; Ma, Zuheng; Björklund, Anneli; Balasuriya, Chandima Nirupa Dilruks; Scholz, Hanne; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2017)We previously showed that hyperoxia in vitro negatively affects beta cells of the rat. Here, we tested for possible clinical significance as well as mitochondrial interactions by hyperoxia, using human islets (function and ... -
Impact of HLA DR3DQ2 and DR4DQ8 haplotypes on autoimmunity, diabetic phenotype, and comorbidity in individuals with LADA: An analysis of data from two clinical trials and the HUNT study
Lønnum, Birte Emilie Ellingsen (Master thesis, 2024)Bakgrunn og hensikt: De viktigste genene assosiert med risiko for autoimmun diabetes er haplotypene HLA-DR3DQ2 og HLA-DR4DQ8. Deres påvirkning på autoimmunitet, diabetisk fenotype og komorbiditet i Latent Autoimmun Diabetes ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
Hals, Ingrid Kathrin; Fleiner, Hanne Fiskvik; Reimers, Nina; Astor, Marianne; Filipsson, Karin; Ma, Zuheng; Grill, Valdemar Erik Robert; Björklund, Anneli (Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Kontaktfri søvnmonitori diagnostikk og oppfølging av søvnapné. Nytteverdi og gjennomførbarhet.
Fossland, Vigdis (Master thesis, 2023)Sammendrag Introduksjon Hovedtemaet i denne masteroppgaven er utprøving av ny teknologi i søvndiagnostikk, utført i pasientens hjem. Vi gjennomførte en klinisk studie der hensikten var å undersøke nytteverdien av søvndata ... -
Latent Autoimmune Diabetes in Adults: Background, Safety and Feasibility of an Ongoing Pilot Study With Intra-Lymphatic Injections of GAD-Alum and Oral Vitamin D
Björklund, Anneli; Hals, Ingrid Kathrin; Grill, Valdemar Erik Robert; Ludvigsson, Johnny (Peer reviewed; Journal article, 2022)Background: Latent Autoimmune Diabetes in Adults (LADA) constitutes around 10% of all diabetes. Many LADA patients gradually lose their insulin secretion and progress to insulin dependency. In a recent trial BALAD (Behandling ... -
On the susceptibility and adaptability of beta cells to stressful conditions: effects of nutrient scarcity, hyperoxia and internalization of amylin
Singh, Rinku (Doctoral theses at NTNU;2018:26, Doctoral thesis, 2018) -
Saving β-Cells from Demise:Effects of in vitro Conditions and Genetic Engineering of UCP-2
Hals, Ingrid Kathrin (Doktoravhandlinger ved NTNU, 1503-8181; 2014:106, Doctoral thesis, 2014)Motverking av skade på β-celler: effekt av endra in vitro-forhold og genetisk manipulering av UCP-2 Beta (β)-cellene, som produserer insulin, ligg samla i såkalla Langerhanske (L) øyer i bukspyttkjertelen. Ved diabetes er ... -
Testing for effects of nicotine on mitochondrial and other functional parameters in insulin-producing ß-cells
Dadadottir, Lovisa Hansen (Master thesis, 2020)Bakgrunn: β-celler inneholder nikotinergiske respetorer, men deres funksjon og potensiell betydning når det kommer til diabetes er imidlertidig ikke fullstendig belyst. Nikotin er det mest aktive stoffet i tobakk og røyking ... -
Testing the flexibility of mitochondrial functioning in insulin-producing β-cells under diabetes like conditions in vitro
Kylling, Mari Slemmen (Master thesis, 2019)Bakgrunn: Kronisk hyperglykemi er skadelig for de insulinproduserende β-cellene i pankreas. Mitokondrienes funksjon i disse cellene er helt essensiell for at β-cellene skal fungere optimalt. Mitokondriene påvirkes trolig ... -
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL-1ra and IL-1 beta is associated with progressive disease
Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)Background Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ... -
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease
Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)Background - Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ...