• Adiposity and risk of decline in glomerular filtration rate: Meta-analysis of individual participant data in a global consortium 

      Chang, Alex R.; Grams, Morgan E.; Ballew, Shoshana H.; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M.; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J.; Li, Yuanying; Miura, Katsuyuki; Navaneethan, Sankar D.; Roderick, Paul J.; Valdivielso, Jose M.; Visseren, Frank L.J.; Zhang, Luxia; Gansevoort, Ron T.; Hallan, Stein; Levey, Andrew S.; Matsushita, Kunihiro; Shalev, Varda; Woodward, Mark (Journal article; Peer reviewed, 2019)
      Objective To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.Design ...
    • Blood pressure, body weight and kidney function in the near-normal range: normality, risk factor or morbidity?  

      Munkhaugen, John (Doktoravhandlinger ved NTNU, Det Medisisnke Fakultet, 15033465; 2010:6, Doctoral thesis, 2010)
    • Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial 

      Langlo, Knut Asbjørn Rise; Lundgren, Kari Margrethe; Zanaboni, Paolo; Mo, Rune; Ellingsen, Øyvind; Hallan, Stein; Aksetøy, Inger-Lise Aamot; Dalen, Håvard (Peer reviewed; Journal article, 2022)
      Aims To investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to ...
    • Circulating microRNAs May Serve as Biomarkers for Hypertensive Emergency End-Organ Injuries and Address Underlying Pathways in an Animal Model 

      Langlo, Knut Asbjørn Rise; Silva, Gustavo Jose Justo; Overrein, Tina Syvertsen; Adams, Volker; Wisløff, Ulrik; Dalen, Håvard; Rolim, Natale Pinheiro Lage; Hallan, Stein (Journal article; Peer reviewed, 2021)
      There is an incomplete understanding of the underlying pathophysiology in hypertensive emergencies, where severely elevated blood pressure causes acute end-organ injuries, as opposed to the long-term manifestations of ...
    • Clinical phenotypes and long-term prognosis in white patients with biopsy-verified hypertensive nephrosclerosis 

      Øvrehus, Marius Altern; Oldereid, Tine Simensen; Dadfar, Aydin; Bjørneklett, Rune; Aasarød, Knut; Fogo, Agnes B.; Ix, Joachim H.; Hallan, Stein (Peer reviewed; Journal article, 2020)
      Introduction Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it is still an insufficiently studied and controversial disease entity. More information on the ...
    • Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial 

      Ikeme, Jesse C.; Katz, Ronit; Muiru, Anthony N.; Estrella, Michelle M.; Scherzer, Rebecca; Garimella, Pranav S.; Hallan, Stein; Peralta, Carmen A.; Ix, Joachim H.; Shlipak, Michael G. (Peer reviewed; Journal article, 2022)
      BACKGROUND Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule ...
    • Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals 

      Winkler, Thomas W.; Rasheed, Humaira; Teumer, Alexander; Gorski, Mathias; Rowan, Bryce X.; Stanzick, Kira J.; Thomas, Laurent; Tin, Adrienne; Hoppmann, Anselm; Chu, Audrey Y.; Tayo, Bamidele; Thio, Chris H. L.; Cusi, Daniele; Chai, Jin-Fang; Sieber, Karsten B.; Horn, Katrin; Li, Man; Scholz, Markus; Cocca, Massimiliano; Wuttke, Matthias; van der Most, Peter J.; Yang, Qiong; Ghasemi, Sahar; Nutile, Teresa; Li, Yong; Pontali, Giulia; Günther, Felix; Dehghan, Abbas; Correa, Adolfo; Parsa, Afshin; Feresin, Agnese; de Vries, Aiko P. J.; Zonderman, Alan B.; Smith, Albert V.; Oldehinkel, Albertine J.; De Grandi, Alessandro; Rosenkranz, Alexander R.; Franke, Andre; Teren, Andrej; Metspalu, Andres; Hicks, Andrew A.; Morris, Andrew P.; Tönjes, Anke; Morgan, Anna; Podgornaia, Anna I.; Peters, Annette; Körner, Antje; Mahajan, Anubha; Campbell, Archie; Freedman, Barry I.; Spedicati, Beatrice; Ponte, Belen; Schöttker, Ben; Brumpton, Ben Michael; Banas, Bernhard; Krämer, Bernhard K.; Jung, Bettina; Åsvold, Bjørn Olav; Smith, Blair H.; Ning, Boting; Penninx, Brenda W. J. H.; Vanderwerff, Brett R.; Psaty, Bruce M.; Kammerer, Candace M.; Langefeld, Carl D.; Hayward, Caroline; Spracklen, Cassandra N.; Robinson-Cohen, Cassianne; Hartman, Catharina A.; Lindgren, Cecilia M.; Wang, Chaolong; Sabanayagam, Charumathi; Heng, Chew-Kiat; Lanzani, Chiara; Khor, Chiea-Chuen; Cheng, Ching-Yu; Fuchsberger, Christian; Gieger, Christian; Shaffer, Christian M.; Schulz, Christina-Alexandra; Willer, Cristen J.; Chasman, Daniel I.; Gudbjartsson, Daniel F.; Ruggiero, Daniela; Toniolo, Daniela; Czamara, Darina; Porteous, David J.; Waterworth, Dawn M.; Mascalzoni, Deborah; Mook-Kanamori, Dennis O.; Reilly, Dermot F.; Daw, E. Warwick; Hofer, Edith; Boerwinkle, Eric; Salvi, Erika; Bottinger, Erwin P.; Tai, E-Shyong; Catamo, Eulalia; Rizzi, Federica; Guo, Feng; Rivadeneira, Fernando; Guilianini, Franco; Sveinbjornsson, Gardar; Ehret, Georg; Waeber, Gerard; Biino, Ginevra; Girotto, Giorgia; Pistis, Giorgio; Nadkarni, Girish N.; Delgado, Graciela E.; Montgomery, Grant W.; Snieder, Harold; Campbell, Harry; White, Harvey D.; Gao, He; Stringham, Heather M.; Schmidt, Helena; Li, Hengtong; Brenner, Hermann; Holm, Hilma; Kirsten, Holgen; Kramer, Holly; Rudan, Igor; Nolte, Ilja M.; Tzoulaki, Ioanna; Olafsson, Isleifur; Martins, Jade; Cook, James P.; Wilson, James F.; Halbritter, Jan; Felix, Janine F.; Divers, Jasmin; Kooner, Jaspal S.; Lee, Jeannette Jen-Mai; O’Connell, Jeffrey; Rotter, Jerome I.; Liu, Jianjun; Xu, Jie; Thiery, Joachim; Ärnlöv, Johan; Kuusisto, Johanna; Jakobsdottir, Johanna; Tremblay, Johanne; Chambers, John C.; Whitfield, John B.; Gaziano, John M.; Marten, Jonathan; Coresh, Josef; Jonas, Jost B.; Mychaleckyj, Josyf C.; Christensen, Kaare; Eckardt, Kai-Uwe; Mohlke, Karen L.; Endlich, Karlhans; Dittrich, Katalin; Ryan, Kathleen A.; Rice, Kenneth M.; Taylor, Kent D.; Ho, Kevin; Nikus, Kjell; Matsuda, Koichi; Strauch, Konstantin; Miliku, Kozeta; Hveem, Kristian; Lind, Lars; Wallentin, Lars; Yerges-Armstrong, Laura M.; Raffield, Laura M.; Phillips, Lawrence S.; Launer, Lenore J.; Lyytikäinen, Leo-Pekka; Lange, Leslie A.; Citterio, Lorena; Klaric, Lucija; Ikram, M. Arfan; Ising, Marcus; Kleber, Marcus E.; Francescatto, Margherita; Concas, Maria Pina; Ciullo, Marina; Piratsu, Mario; Orho-Melander, Marju; Laakso, Markku; Loeffler, Markus; Perola, Markus; de Borst, Martin H.; Gögele, Martin; Bianca, Martina La; Lukas, Mary Ann; Feitosa, Mary F.; Biggs, Mary L.; Wojczynski, Mary K.; Kavousi, Maryam; Kanai, Masahiro; Akiyama, Masato; Yasuda, Masayuki; Nauck, Matthias; Waldenberger, Melanie; Chee, Miao-Li; Chee, Miao-Ling; Boehnke, Michael; Preuss, Michael H.; Stumvoll, Michael; Province, Michael A.; Evans, Michele K.; O’Donoghue, Michelle L.; Kubo, Michiaki; Kähönen, Mika; Kastarinen, Mika; Nalls, Mike A.; Kuokkanen, Mikko; Ghanbari, Mohsen; Bochud, Murielle; Josyula, Navya Shilpa; Martin, Nicholas G.; Tan, Nicholas Y. Q.; Palmer, Nicholette D.; Pirastu, Nicola; Schupf, Nicole; Verweij, Niek; Hutri-Kähönen, Nina; Mononen, Nina; Bansal, Nisha; Devuyst, Olivier; Melander, Olle; Raitakari, Olli T.; Polasek, Ozren; Manunta, Paolo; Gasparini, Paolo; Mishra, Pashupati P.; Sulem, Patrick; Magnusson, Patrik K. E.; Elliott, Paul; Ridker, Paul M.; Hamet, Pavel; Svensson, Per O.; Joshi, Peter K.; Kovacs, Peter; Pramstaller, Peter P.; Rossing, Peter; Vollenweider, Peter; van der Harst, Pim; Dorajoo, Rajkumar; Sim, Ralene Z. H.; Burkhardt, Ralph; Tao, Ran; Noordam, Raymond; Mägi, Reedik; Schmidt, Reinhold; de Mutsert, Renée; Rueedi, Rico; van Dam, Rob M.; Carroll, Robert J.; Gansevoort, Ron T.; Loos, Ruth J. F.; Felicita, Sala Cinzia; Sedaghat, Sanaz; Padmanabhan, Sandosh; Freitag-Wolf, Sandra; Pendergrass, Sarah A.; Graham, Sarah E.; Gordon, Scott D.; Hwang, Shih-Jen; Kerr, Shona M.; Vaccargiu, Simona; Patil, Snehal B.; Hallan, Stein; Bakker, Stephan J. L.; Lim, Su-Chi; Lucae, Susanne; Vogelezang, Suzanne; Bergmann, Sven; Corre, Tanguy; Ahluwalia, Tarunveer S.; Lehtimäki, Terho; Boutin, Thibaud S.; Meitinger, Thomas; Wong, Tien-Yin; Bergler, Tobias; Rabelink, Ton J.; Esko, Tõnu; Haller, Toomas; Thorsteinsdottir, Unnur; Völker, Uwe; Foo, Valencia Hui Xian; Salomaa, Veikko; Vitart, Veronique; Giedraitis, Vilmantas; Gudnason, Vilmundur; Jaddoe, Vincent W. V.; Huang, Wei; Zhang, Weihua; Wei, Wen Bin; Kiess, Wieland; März, Winfried; Koenig, Wolfgang; Lieb, Wolfgang; Gao, Xin; Sim, Xueling; Wang, Ya Xing; Friedlander, Yechiel; Tham, Yih-Chung; Kamatani, Yoichiro; Okada, Yukinori; Milaneschi, Yuri; Yu, Zhi; Thio, Chris H. L.; van der Most, Peter J.; de Borst, Martin H.; Ho, Kevin; Josyula, Navya Shilpa; Pendergrass, Sarah A.; Rowan, Bryce X.; Robinson-Cohen, Cassianne; Gaziano, John M.; Phillips, Lawrence S.; Tao, Ran; Hung, Adriana M.; Stark, Klaus J.; Stefansson, Kari; Böger, Carsten A.; Hung, Adriana M.; Kronenberg, Florian; Köttgen, Anna; Pattaro, Cristian; Heid, Iris M. (Peer reviewed; Journal article, 2022)
      Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses ...
    • Direction- and Angle-Assisted Buttonhole Cannulation of Arteriovenous Fistula in Hemodialysis Patients: A Multicenter Randomized Controlled Trial 

      Rønning, Marit I.; Benschop, Willem Pieter; Øvrehus, Marius Altern; Hultstrøm, Maria; Hallan, Stein (Peer reviewed; Journal article, 2022)
      Rationale & objective: Arteriovenous fistula cannulation with the buttonhole technique is often preferred by patients but has been associated with an increased infection risk. Guidelines disagree on whether it should be ...
    • Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals 

      Stanzick, Kira J.; Li, Yong; Schlosser, Pascal; Gorski, Mathias; Wuttke, Matthias; Thomas, Laurent F.; Rasheed, Humaira; Rowan, Bryce X.; Graham, Sarah E.; Vanderweff, Brett R.; Patil, Snehal B.; Robinson-Cohen, Cassiane; Gaziano, John M.; O’Donnell, Christopher J.; Willer, Cristen J.; Hallan, Stein; Åsvold, Bjørn Olav; Gessner, Andre; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna; Stark, Klaus; Heid, Iris M.; Winkler, Thomas W. (Journal article; Peer reviewed, 2021)
      Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ...
    • Estimated Kidney Tubular Secretion and Kidney, Cardiovascular, and Mortality Outcomes in CKD: The Systolic Blood Pressure Intervention Trial 

      Ascher, Simon B.; Shlipak, Michael G.; Katz, Ronit; Bullen, Alexander L.; Scherzer, Rebecca; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Seegmiller, Jesse C.; Ix, Joachim H.; Garimella, Pranav S. (Peer reviewed; Journal article, 2022)
      Rational & Objective Many drugs, metabolites, and toxins are cleared by the kidneys via tubular secretion. Whether novel endogenous measures of tubular secretion provide information about kidney, cardiovascular, and ...
    • Gene expression studies and targeted metabolomics reveal disturbed serine, methionine, and tyrosine metabolism in early hypertensive nephrosclerosis 

      Øvrehus, Marius Altern; Bruheim, Per; Ju, Wenjun; Zelnick, Leila R.; Langlo, Knut Asbjørn Rise; Sharma, Kumar; de Boer, Ian H.; Hallan, Stein (Journal article; Peer reviewed, 2019)
      Introduction Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology is poorly understood. We wanted to explore early metabolic changes using gene expression and targeted ...
    • Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies 

      Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent; Graham, Sarah E.; Sveinbjornsson, Gardar; Winkler, Thomas W.; Günther, Felix; Stark, Klaus J.; Chai, Jin-Fang; Tayo, Bamidele O.; Wuttke, Matthias; Li, Yong; Tin, Adrienne; Ahluwalia, Tarunveer S.; Ärnlöv, Johan; Åsvold, Bjørn Olav; Bakker, Stephan J.L.; Banas, Bernhard; Bansal, Nisha; Biggs, Mary L.; Biino, Ginevra; Böhnke, Michael; Boerwinkle, Eric; Bottinger, Erwin P.; Brenner, Hermann; Brumpton, Ben Michael; Carroll, Robert J.; Chaker, Layal; Chalmers, John; Chee, Miao-Li; Chee, Miao-Ling; Cheng, Ching-Yu; Chu, Audrey Y.; Ciullo, Marina; Cocca, Massimiliano; Cook, James P.; Coresh, Josef; Cusi, Daniele; de Borst, Martin H.; Degenhardt, Frauke; Eckardt, Kai-Uwe; Endlich, Karlhans; Evans, Michele K.; Feitosa, Mary F.; Franke, Andre; Freitag-Wolf, Sandra; Fuchsberger, Christian; Gampawar, Piyush; Gansevoort, Ron T.; Ghanbari, Mohsen; Ghasemi, Sahar; Giedraitis, Vilmantas; Gieger, Christian; Gudbjartsson, Daniel F.; Hallan, Stein; Hamet, Pavel; Hishida, Asahi; Ho, Kevin; Hofer, Edith; Holleczek, Bernd; Holm, Hilma; Hoppmann, Anselm; Horn, Katrin; Hutri-Kähönen, Nina; Hveem, Kristian; Hwang, Shih-Jen; Ikram, M. Arfan; Josyula, Navya Shilpa; Jung, Bettina; Kähönen, Mika; Karabegović, Irma; Khor, Chiea-Chuen; Koenig, Wolfgang; Kramer, Holly; Krämer, Bernhard K.; Kühnel, Brigitte; Kuusisto, Johanna; Laakso, Markku; Lange, Leslie A.; Lehtimäki, Terho; Li, Man; Lieb, Wolfgang; Lind, Lars; Lindgren, Cecilia M.; Loos, Ruth J.F.; Lukas, Mary Ann; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Matias-Garcia, Pamela R.; Meisinger, Christa; Meitinger, Thomas; Melander, Olle; Milaneschi, Yuri; Mishra, Pashupati P.; Mononen, Nina; Morris, Andrew P.; Mychaleckyj, Josyf C.; Nadkarni, Girish N.; Naito, Mariko; Nakatochi, Masahiro; Nalls, Mike A.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Nolte, Ilja M.; Nutile, Teresa; O'Donoghue, Michelle L.; O'Connell, Jeffrey; Olafsson, Isleifur; Orho-Melander, Marju; Parsa, Afshin; Pendergrass, Sarah A.; Penninx, Brenda W.J.H.; Pirastu, Mario; Preuss, Michael H.; Psaty, Bruce M.; Raffield, Laura M.; Raitakari, Olli T.; Rheinberger, Myriam; Rice, Kenneth M.; Rizzi, Federica; Rosenkranz, Alexander R.; Rossing, Peter; Rotter, Jerome I.; Ruggiero, Daniela; Ryan, Kathleen A.; Sabanayagam, Charumathi; Salvi, Erika; Schmidt, Helena; Schmidt, Reinhold; Scholz, Markus; Schöttker, Ben; Schulz, Christina-Alexandra; Sedaghat, Sanaz; Shaffer, Christian M.; Sieber, Karsten B.; Sim, Xueling; Sims, Mario; Snieder, Harold; Stanzick, Kira J.; Thorsteinsdottir, Unnur; Stocker, Hannah; Strauch, Konstantin; Stringham, Heather M.; Sulem, Patrick; Szymczak, Silke; Taylor, Kent D.; Thio, Chris H.L.; Tremblay, Johanne; Vaccargiu, Simona; van der Harst, Pim; van der Most, Peter J.; Verweij, Niek; Völker, Uwe; Wakai, Kenji; Waldenberger, Melanie; Wallentin, Lars; Wallner, Stefan; Wang, Judy; Waterworth, Dawn M.; White, Harvey D.; Willer, Cristen J.; Wong, Tien-Yin; Woodward, Mark; Yang, Qiong; Yerges-Armstrong, Laura M.; Zimmermann, Martina; Zonderman, Alan B.; Bergler, Tobias; Stefansson, Kari; Böger, Carsten A.; Pattaro, Cristian; Köttgen, Anna; Kronenberg, Florian; Heid, Iris M. (Peer reviewed; Journal article, 2022)
      Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies ...
    • Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics 

      Hallan, Stein; Øvrehus, Marius Altern; Bjørneklett, Rune; Aasarød, Knut Ivar; Fogo, Agnes B.; Ix, Joachim H. (Peer reviewed; Journal article, 2020)
      Background. Hypertensive nephrosclerosis is the presumed underlying cause in many end-stage kidney disease (ESKD) patients, but the diagnosis is disputed and based on clinical criteria with low diagnostic accuracy. Objective. ...
    • Implementing the European Renal Best Practice Guidelines suggests that prediction equations work well to differentiate risk of end-stage renal disease vs. death in older patients with low estimated glomerular filtration rate 

      Hallan, Stein; Rifkin, Dena E; Potok, O Alison; Katz, Ronit; Langlo, Knut Asbjørn Rise; Bansal, Nisha; Ix, Joachim H (Journal article; Peer reviewed, 2019)
      Recent European guidelines suggest using the kidney failure risk equation (KFRE) and mortality risk equation for kidney disease (MREK) to guide decisions on whether elderly patients with chronic kidney disease should be ...
    • Increased long-term risk for hypertension in kidney donors – a retrospective cohort study 

      Haugen, Anders Johan Smedman; Hallan, Stein; Langberg, Nina Elisabeth Borthen; Dahle, Dag Olav; Pihlstrøm, Hege; Birkeland, Kåre I.; Reisæter, Anna Varberg; Midtvedt, Karsten; Hartmann, Anders; Holdaas, Hallvard; Mjøen, Geir (Peer reviewed; Journal article, 2020)
      Kidney donors may be at increased risk of end-stage renal disease and premature mortality. Elevated blood pressure after donation may contribute to the increased risks. In this cohort study, we have assessed long-term risk ...
    • Increased risk of ischaemic heart disease after kidney donation 

      Haugen, Anders Johan Smedman; Hallan, Stein; Langberg, Nina Elisabeth Borthen; Dahle, Dag Olav; Pihlstrøm, Hege K.; Birkeland, Kåre Inge; Reisæter, Anna Varberg; Midtvedt, Karsten; Hartmann, Anders; Holdaas, Hallvard; Mjøen, Geir (Peer reviewed; Journal article, 2021)
      Background Previous reports suggest increased risk of hypertension and cardiovascular mortality after kidney donation. In this study we investigate the occurrence of ischaemic heart disease and cerebrovascular disease, ...
    • Increased risk of ischaemic heart disease after kidney donation 

      Haugen, Anders Johan Smedman; Hallan, Stein; Langberg, Nina Elisabeth Borthen; Dahle, Dag Olav; Pihlstrøm, Hege K.; Birkeland, Kåre Inge; Reisæter, Anna Varberg; Midtvedt, Karsten; Hartmann, Anders; Holdaas, Hallvard; Mjøen, Geir (Peer reviewed; Journal article, 2022)
      Background - Previous reports suggest increased risk of hypertension and cardiovascular mortality after kidney donation. In this study we investigate the occurrence of ischaemic heart disease and cerebrovascular disease, ...
    • Long-term progression of hypertensive nephropathy (nephrosclerosis) 

      Dadfar, Aydin (Master thesis, 2013)
      Background: Over the last 30 years, there has been an increase in the number of patients with hypertensive nephropathy. Nephrosclerosis is now one of the most common causes of end stage renal disease (ESRD). The objective ...