Browsing NTNU Open by Author "Hall, Martina"
Now showing items 1-11 of 11
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A Polygenic Risk Score Analysis for Cardiovascular Diseases using a PheWAS Network
Skinderhaug, Marit Kveberg (Master thesis, 2021)Feltene genome-wide association studies og nettverksteori har hatt stor utvikling over de siste årene, og har bidratt til viktige oppdagelser og teknologier. I denne masteroppgaven har bruk av nettverksteori og genome-wide ... -
Applied statistical methods and network analysis for identifying similarities and differences in biological data for various traits.
Hall, Martina (Doctoral theses at NTNU;2024:421, Doctoral thesis, 2024)"Observing differences in various traits, such as differences in human height, why some people are more susceptible to certain diseases, or why some species survive in certain environments, we often question why and how ... -
Containing pandemics through targeted testing of households
Voigt, Andre; Martyushenko, Nikolay; Karlsen, Emil; Hall, Martina; Nyhamar, Kristen; Omholt, Stig William; Almaas, Eivind (Peer reviewed; Journal article, 2021)Background While invasive social distancing measures have proven efficient to control the spread of pandemics failing wide-scale deployment of vaccines, they carry vast societal costs. The development of a diagnostic ... -
The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems
Rye, Morten Beck; Krossa, Sebastian; Hall, Martina; van Mourik, Casper; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt; Bertilsson, Helena (Peer reviewed; Journal article, 2022)High secretion of the metabolites citrate and spermine is a unique hallmark for normal prostate epithelial cells, and is reduced in aggressive prostate cancer. However, the identity of the genes controlling this biological ... -
GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
Neckmann, Ulrike; Wolowczyk, Camilla; Hall, Martina; Almaas, Eivind; Ren, Jiang; Zhao, Sen; Johannessen, Bjarne; Skotheim, Rolf I.; Bjørkøy, Geir; Dijke, Peter Ten; Holien, Toril (Journal article; Peer reviewed, 2019)Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of ... -
Human Phenotype Prediction Through use of Variant Data in Metabolic Modeling
Landa, Sigve Strand (Master thesis, 2022)Føremålet med dette prosjektet var utvikling av ein metode for bruk av variasjonsdata til å selektere gen for fjerning i metabolsk modellering. Motivasjonen er moglegheita til å kunne oppdage sjukdomsframkallande variantar, ... -
Integrating large-scale data for biological network construction and analysis
Pettersen, Jakob Peder (Doctoral theses at NTNU;2023:205, Doctoral thesis, 2023)Recent advances in technology has enabled scientists to extract large amounts of data from biological experiments. Due to the scale of the data, computational analyses are required in order to arrive at meaningful ... -
NRF2 drives an oxidative stress response predictive of breast cancer
Wolowczyk, Camilla; Neckmann, Ulrike; Aure, Miriam Ragle; Hall, Martina; Johannessen, Bjarne; Zhao, Sen; Skotheim, Rolf I.; Andersen, Sonja Benedikte; Zwiggelaar, Rosalie Theda Margien; Steigedal, Tonje S.; Lingjærde, Ole Christian; Sahlberg, Kristine Kleivi; Almaas, Eivind; Bjørkøy, Geir (Peer reviewed; Journal article, 2022)Many breast cancer patients are diagnosed with small, well-differentiated, hormone receptor-positive tumors. Risk of relapse is not easily identified in these patients, resulting in overtreatment. To identify metastasis-related ... -
Phenotypic response of yeast metabolic network to availability of proteinogenic amino acids
Simensen, Vetle; Seif, Yara; Hall, Martina (Peer reviewed; Journal article, 2022)Genome-scale metabolism can best be described as a highly interconnected network of biochemical reactions and metabolites. The flow of metabolites, i.e., flux, throughout these networks can be predicted and analyzed using ... -
Statistical Methods for early Prediction of Cerebral Palsy based on Data from Computer-based Video Analysis
Hall, Martina (Master thesis, 2017)In this thesis we have investigated the association between summary variables from the General Movement Toolbox (GMT), and cases of abnormal fidgety movements (FMs) and cerebral palsy (CP). The GMT-software calculates ... -
Using differential co-expression analysis to investigate breast cancer subtypes and the use of histologically normal cancer-adjacent tissue as the control
Salvesen, Kristin (Master thesis, 2021)Den økte tilgjengeligheten av store RNA-sekvensering og DNA mikromatrisestudier muliggjør forskning av sammenhenger mellom gener ved samuttrykksanalyser. Endringer i samuttrykksmønstre er ofte relatert til endringer i ...