• Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy 

      Zhao, Yiming; Fay, Francois; Hak, Sjoerd; Manuel Perez-Aguilar, Jose; Sanchez-Gaytan, Brenda L; Goode, Brandon; Duivenvoorden, Raphael; Davies, Ruth Catharina de Lange; Bjørkøy, Astrid; Weinstein, Harel; Fayad, Zahi A; Perez-Medina, Carlos; Mulder, Willem J M (Journal article; Peer reviewed, 2016)
      A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to ...
    • Hypoxic-ischemic brain injury: Melatonin treatment with lipid-based nanoparticles 

      Molska, Alicja (Doctoral thesis, 2021)
      Lave nivå av oksygen og begrenset blodforsyning rundt fødsel, også kjent som perinatal hypoksisk iskemi (HI), kan forårsake hjerneskade gjennom en progressiv kaskade (1). HIindusert hjerneskade er en av de viktigste årsakene ...
    • Iron oxide nanocrystals clustered in oil-in-water nanoemulsions: Preparation, characterization, and transverse relaxivities 

      Hadera, Hailay Teklegiorgis (Master thesis, 2015)
      Iron oxide nanocrystals (IONCs) have attracted extensive interest due to their high magnetization that efficiently decreases the transverse relaxation times of water protons. The increase in their transverse relaxivities ...
    • L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles 

      McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2016)
      Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active ...
    • Labeling nanoparticles: Dye leakage and altered cellular uptake 

      Snipstad, Sofie; Hak, Sjoerd; Baghirov, Habib; Sulheim, Einar; Mørch, Ýrr Asbjørg; Lelu, Sylvie; von Haartman, Eva; Bäck, Marcus; Nilsson, Peter R; Klymchenko, Andrey S; Davies, Ruth Catharina de Lange; Åslund, Andreas (Journal article, 2016)
      In vitro and in vivo behavior of nanoparticles (NPs) is often studied by tracing the NPs with fluorescent dyes. This requires stable incorporation of dyes within the NPs, as dye leakage may give a wrong interpretation of ...
    • Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles 

      Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)
      The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ...
    • Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery 

      Mørch, Ýrr Asbjørg; Hansen, Rune; Berg, Sigrid; Åslund, Andreas; Glomm, Wilhelm; Eggen, Siv; Schmid, Ruth; Johnsen, Heidi; Kubowicz, Stephan; Snipstad, Sofie; Sulheim, Einar; Hak, Sjoerd; Singh, Gurvinder; McDonagh, Birgitte Hjelmeland; Blom, Hans; Davies, Ruth Catharina de Lange; Stenstad, Per Martin (Journal article, 2015)
      Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ...
    • Optimization of oil-in-water nanoemulsions for tumor targeting and molecular dynamic contrast enhanced MRI 

      Hak, Sjoerd (Doktoravhandlinger ved NTNU, 1503-8181; 2013:350, Doctoral thesis, 2013)
    • Quantitative analysis of binding and internalization of αvβ3 integrin-targeted nanoemulsions by human endothelial cells: In vitro 

      Hegvik, Maria Garli (Master thesis, 2016)
      The purpose of this master thesis was to quantitatively study the binding and internalization of αvβ3 integrin-targeted RGD-conjugated nanoemulsions (RGD-NE) by human umbilical vein endothelial cells (HUVEC) in vitro. The ...
    • Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice 

      Sofias, Alexandros Marios; Åslund, Andreas; Hagen, Nils; Grendstad, Kristin; Hak, Sjoerd (Peer reviewed; Journal article, 2019)
      Purpose The endeavor of deciphering intricate phenomena within the field of molecular medicine dictates the necessity to investigate tumor/disease microenvironment real-time on cellular level. We, hereby, design simple and ...
    • Targeted nanoparticles for drug delivery and molecular imaging 

      Guercini, Emanuele (Master thesis, 2016)
      This study involved experiments on signal colocalization between αvβ3 integrin and RGD conjugated nanoemulsions as well as studies on nanoemulsion distribution and differences between the internalization patterns of RGD-NE ...
    • Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking 

      Sofias, Alexandros Marios; Toner, Yohana C.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Soultanidis, Georgios; Elschot, Mattijs; Gonai, Haruki; Grendstad, Kristin; Flobak, Åsmund; Neckmann, Ulrike; Wolowczyk, Camilla; Fisher, Elizabeth L.; Reiner, Thomas; Davies, Catharina de Lange; Bjørkøy, Geir; Teunissen, Abraham J. P.; Ochando, Jordi; Pérez-Medina, Carlos; Mulder, Willem J. M.; Hak, Sjoerd (Journal article; Peer reviewed, 2020)
      Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ...
    • Unraveling the multifaceted in vivo fate of cancer nanomedicine 

      Sofias, Alexandros Marios (Doctoral theses at NTNU;2019:369, Doctoral thesis, 2019)