Blar i NTNU Open på forfatter "Gullestad, Lars"

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    • 6 min walk test is a strong independent predictor of death in outpatients with heart failure 

      Grundtvig, Morten; Eriksen-Volnes, Torfinn; Ørn, Stein; Slind, Eva Kjøl; Gullestad, Lars (Peer reviewed; Journal article, 2020)
      The aim of this study was to examine the prognostic value of the 6 min walk test (6MWT) in a large cohort of outpatients with heart failure. Methods and results A total of 5519 outpatients with heart failure from the ...

    • The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure 

      Shahini, Negar; Bjørkelund, Elisabeth; Bendz, Christina; Massey, Richard J; Schjalm, Camilla; Halvorsen, Bente; Broch, Kaspar; Ueland, Thor; Gullestad, Lars; Nilsson, Per H.; Aukrust, Pål; Mollnes, Tom Eirik; Louwe, Maria Cornelia (Journal article; Peer reviewed, 2021)
      Objective Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase ...

    • Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis 

      Niyonzima, Nathalie; Bakke, Siril S.; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang; Sporsheim, Bjørnar; Ryan, Liv; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Skjelland, Mona; Sørensen, Kirsten; Rokstad, Anne Mari A.; Yndestad, Arne; Latz, Eicke; Gullestad, Lars; Andersen, Geir Øystein; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Halvorsen, Bente; Espevik, Terje (Peer reviewed; Journal article, 2020)
      Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ...

    • Circular RNA Profile in Atherosclerotic Disease: Regulation during ST-Elevated Myocardial Infarction 

      Holme, Fredric A.; Huse, Camilla; Kong, Xiang Yi; Broch, Kaspar; Gullestad, Lars; Anstensrud, Anne Kristine; Andersen, Geir Øystein; Amundsen, Brage H.; Kleveland, Ola; Quiles-Jiménez, Ana M T; Holm, Sverre; Aukrust, Pål; Alseth, Ingrun; Halvorsen, Bente; Dahl, Tuva Børresdatter (Journal article; Peer reviewed, 2024)
      Circular (circ) RNAs are non-coding RNAs with important functions in the nervous system, cardiovascular system, and cancer. Their role in atherosclerosis and myocardial infarction (MI) remains poorly described. We aim to ...

    • A clinical evaluation of a low-cost strain gauge respiration belt and machine learning to detect sleep apnea 

      Kristiansen, Stein; Nikolaidis, Konstantinos; Plagemann, Thomas Peter; Goebel, Vera Hermine; Traaen, Gunn Marit; Øverland, Britt; Akerøy, Lars; Hunt, Tove Elizabeth Frances; Loennechen, Jan Pål; Steinshamn, Sigurd Loe; Bendz, Christina; Anfinsen, Ole-Gunnar; Gullestad, Lars; Akre, Harriet (Peer reviewed; Journal article, 2023)
      Sleep apnea is a common and severe sleep-related respiratory disorder. Since the symptoms of sleep apnea are often ambiguous, it is difficult for a physician to decide whether to prescribe a clinical diagnosis, i.e., ...

    • Comparing manual and automatic scoring of sleep monitoring data from portable polygraphy 

      Kristiansen, Stein; Traaen, Gunn Marit; Øverland, Britt; Plagemann, Thomas Peter; Gullestad, Lars; Akre, Harriet; Nikolaidis, Konstantinos; Aakerøy, Lars; Hunt, Tove Elizabeth Frances; Loennechen, Jan Pål; Steinshamn, Sigurd Loe; Bendz, Christina; Anfinsen, Ole-Gunnar; Goebel, Vera Hermine (Journal article; Peer reviewed, 2020)
      We used sleep monitoring data from a study that investigated the prevalence, characteristics, risk factors and type of sleep apnea (SA) in 579 patients with paroxysmal atrial fibrillation. Most patients were screened for ...

    • Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab 

      Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar; Tøllefsen, Ingvild Maria; Ryan, Liv; Bendz, Bjørn; Hopp, Einar; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Andersen, Geir Øystein; Gullestad, Lars; Wiseth, Rune; Amundsen, Brage H.; Damås, Jan Kristian; Kleveland, Ola (Peer reviewed; Journal article, 2023)
      Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab ...

    • Development of a tool to predict the risk of incident heart failure in a general population: the HUNT for HF risk score 

      Ofstad, Anne Pernille; Brunborg, Cathrine; Johansen, Odd Erik; Mørkedal, Bjørn; Fagerland, Morten; Laugsand, Lars Erik; Gullestad, Lars; Dalen, Håvard (Peer reviewed; Journal article, 2023)
      Aims Currently, no incident heart failure (HF) risk score that is in regular use in a general population is available. We aimed to develop this and compare with existing HF risk scores. Methods and results Participants ...

    • Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial 

      Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar; Holte, Espen; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Espevik, Terje; Aakhus, Svend; Damås, Jan Kristian; Aukrust, Pål; Wiseth, Rune; Gullestad, Lars (Journal article; Peer reviewed, 2016)
      Aims Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia–reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial ...

    • Effect of continuous positive airway pressure therapy on recurrence of atrial fibrillation after pulmonary vein isolation in patients with obstructive sleep apnea: A randomized controlled trial 

      Hunt, Tove Elizabeth Frances; Traaen, Gunn Marit; Aakerøy, Lars; Bendz, Christina; Øverland, Britt; Akre, Harriet; Steinshamn, Sigurd Loe; Loennechen, Jan Pål; Hegbom, Finn; Broch, Kaspar; Lie, Øyvind Haugen; Lyseggen, Erik; Haugaa, Kristina Ingrid Helena Hermann; Gullestad, Lars; Anfinsen, Ole-Gunnar (Peer reviewed; Journal article, 2022)
      Background Obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF). Whether treatment with continuous positive airway pressure (CPAP) reduces AF recurrence after catheter ablation with pulmonary vein ...

    • Eliciting Patient Risk Willingness in Clinical Consultations as a Means of Improving Decision-Making of Aortic Valve Replacement 

      Hussain, Amjad; Garratt, Andrew; Brunborg, Cathrine; Aakhus, Svend; Gullestad, Lars; Pettersen, Kjell I (Journal article; Peer reviewed, 2016)
      Background: Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. Methods and Results: We assessed ...

    • IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction 

      Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2018)
      Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their ...

    • Impaired right ventricular function in long-term survivors of allogeneic haematopoietic stem-cell transplantation 

      Massey, Richard; Diep, Phoi Phoi; Burman, Marta Maria; Kvaslerud, Anette Borger; Brinch, Lorentz; Aakhus, Svend; Gullestad, Lars; Ruud, Ellen; Beitnes, Jan Otto (Journal article; Peer reviewed, 2021)
      Aims Survivors of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) are at higher risk of cardiovascular disease. We aimed to describe right ventricular (RV) systolic function and risk factors for RV dysfunction ...

    • Increased complement factor B and Bb levels are associated with mortality in patients with severe aortic stenosis 

      Shahini, Negar; Ueland, Thor; Auensen, Andreas; Michelsen, Annika; Ludviksen, Judith K; Hussain, Amjad Iqbal; Pettersen, Kjell; Aakhus, Svend; Espeland, Torvald; Lunde, Ida Gjervold; Kirschfink, Michael; Nilsson, Per; Mollnes, Tom Eirik; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne; Louwe, Maria Cornelia (Journal article; Peer reviewed, 2019)
      Inflammation is involved in initiation and progression of aortic stenosis (AS). However, the role of the complement system, a crucial component of innate immunity in AS, is unclear. We hypothesized that circulating levels ...

    • Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)
      We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ...

    • Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction 

      Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Peer reviewed, 2018)
      Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised ...

    • Left Ventricular Systolic Function in Long-Term Survivors of Allogeneic Hematopoietic Stem Cell Transplantation 

      Massey, Richard J; Diep, Phoi Phoi; Ruud, Ellen; Burman, Marta Maria; Kvaslerud, Anette Borger; Brinch, Lorentz; Aakhus, Svend; Gullestad, Lars; Beitnes, Jan Otto (Peer reviewed; Journal article, 2020)
      Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT), a potentially curative therapy for malignant and nonmalignant diseases, is being increasingly used in younger patients. Although allo-HSCT survivors ...

    • Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages 

      Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre; Kong, Xiang Yi; Michelsen, Annika; Otterdal, Kari; Yndestad, Arne; Broch, Kaspar; Gullestad, Lars; Nyman, Tuula Anneli; Bendz, Bjørn; Eritsland, Jan; Hoffmann, Pavel; Skagen, Karolina Ryeng; Gonçalves, Isabel; Nilsson, Jan; Grenegård, Magnus; Poreba, Marcin; Drag, Marcin; Seljeflot, Ingebjørg; Sporsheim, Bjørnar; Espevik, Terje; Skjelland, Mona; Johansen, Harald Thidemann; Solberg, Rigmor; Aukrust, Pål; Björbacka, Harry; Andersen, Geir Øystein; Halvorsen, Bente (Peer reviewed; Journal article, 2019)
      Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ...

    • Myokardfibrose 

      Espeland, Torvald; Lunde, Ida Gjervold; Amundsen, Brage H.; Gullestad, Lars; Aakhus, Svend (Journal article; Peer reviewed, 2018)
      BAKGRUNN Myokardfibrose oppstår sekundært til kardial belastning eller skade. I denne oversiktsartikkelen presenteres sentrale aspekter ved myokardfibrose. KUNNSKAPSGRUNNLAG Vi foretok 2 søk i PubMed som til sammen ...

    • NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture 

      Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine; Palibrk, Vuk; Wang, Junbai; Neurauter, Christine Gran; Gomez, Luisa Fernanda Luna; Johansen, Jostein; Øgaard, Jonas; Ohm, Ingrid Kristine; Slupphaug, Geir; Kusnierczyk, Anna; Fiane, Arnt E; Brorson, Sverre Henning; Zhang, Lili; Gullestad, Lars; Louch, William Edward; Iversen, Per Ole; Østlie, Ingunn; Klungland, Arne; Christensen, Geir Arve; Sjaastad, Ivar; Sætrom, Pål; Yndestad, Arne; Aukrust, Pål; Bjørås, Magnar; Finsen, Alexandra (Journal article; Peer reviewed, 2017)
      Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a ...