Blar i NTNU Open på forfatter "Grinde, Maria Tunset"
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31P MRS protocol optimization and repeatability testing in calf muscle of healthy volunteers on a clinical 7 Tesla MR scanner
Norum, Andreas (Master thesis, 2021)Hovedmålet for denne masteroppgaven var å etablere en skannprotokoll og evaluere repeterbarheten i 31P MRS i leggmuskelen hos friske frivillige på den kliniske 7T MR-skanneren ved St. Olavs Hospital. Startpunktet for ... -
Assessing RF-Induced Heating of Orthopedic Implants in Ultra-High Field MRI: Influencing Factors and the Effect of Parallel Transmission
Halvorsen, Dan Kristina (Master thesis, 2023)Dette studiet undersøker radiofrekvens (RF)-indusert oppvarming av ulike implantater i et gelhodefantom ved bruken av 7T magnetresonanstomografi (MRI). Utviklingen mot høyere statisk magnetfeltstyrker i MRI har ført til ... -
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Pandya, Abhilash D.; Iversen, Tore Geir; Moestue, Siver Andreas; Grinde, Maria Tunset; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Øy, Geir Frode; Kildal, Wanja; Engebråten, Olav; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Peer reviewed; Journal article, 2021)We have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs): PEBCA (poly(2-ethyl-butyl cyanoacrylate), PBCA (poly(n-butyl ... -
Biomarker discovery using NMR based metabolomics of tissue
Grinde, Maria Tunset; Giskeødegård, Guro F.; Andreassen, Trygve; Tessem, May-Britt; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic ... -
Characterization of breast cancer using MR metabolomics and gene expression analysis
Grinde, Maria Tunset (Doktoravhandlinger ved NTNU, 1503-8181; 2012:282, Doctoral thesis, 2012)Brystkreft er den vanligste kreftformen blant kvinner i Norge. Prognose og overlevelse avhenger av type kreft, tumorstørrelse, lymfeknutemetastaser og reseptorstatus (østrogen, progesteron og HER2). Basert på genekspresjonanalyser ... -
Effect of Glutaminase Inhibition in Basal-Like Patient-Derived Xenografts Analyzed by Magnetic Resonance Spectroscopy
Henriksen, Ida Marie (Master thesis, 2017)Breast cancer is today the leading cause for cancer related deaths among women in Europe. Decreased mortality among breast cancer patients has been observed over the last twenty years, where development and use of targeted ... -
EMT-derived alterations in glutamine metabolism sensitize mesenchymal breast cells to mTOR inhibition
Karvelsson, Sigurdur; Sigurdsson, Arnar; Seip, Kotryna; Grinde, Maria Tunset; Wang, Qiong; Johanssson, Freyr; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Rolfsson, Ottar; Halldórsson, Skarphédinn (Peer reviewed; Journal article, 2021)Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process with strong implications in cancer progression. Understanding the metabolic alterations associated with EMT may open new avenues of treatment ... -
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 ... -
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts
Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr; Sitter, Beathe; Bathen, Tone; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Engebråten, Olav; Sørlie, Therese; Marangoni, Elisabetta; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2014)Introduction Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a large ... -
Metabolic profiling of colorectal cancer organoids: A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts
van der Kemp, Wybe J. M.; Grinde, Maria Tunset; Malvik, Jon Olav; van Laarhoven, Hanneke W. M.; Prompers, Jeanine J.; Klomp, Dennis W. J.; Burgering, Boudewijn; Bathen, Tone Frost; Moestue, Siver Andreas (Peer reviewed; Journal article, 2022)Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological ... -
NMR-Based Prostate Cancer Metabolomics
Euceda, Leslie R.; Andersen, Maria Karoline; Tessem, May-Britt; Moestue, Siver Andreas; Grinde, Maria Tunset; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)Prostate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish ... -
Segmentation of the Cervical Spine based on 7T MRI
Sandbu, Sebastian Albert Dahl (Master thesis, 2023)Ultrahøyfelt-MR (UHF-MR), som 7T, har potensial til å forbedre bildekvaliteten i MR-undersøkelser gjennom økt oppløsning og forbedret signal-til-støy-forhold (SNR). Imidlertid introduserer UHF- MR også mer markante ...