• Biomarker discovery using NMR based metabolomics of tissue 

      Grinde, Maria Tunset; Giskeødegård, Guro F.; Andreassen, Trygve; Tessem, May-Britt; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic ...
    • Characterization of breast cancer using MR metabolomics and gene expression analysis 

      Grinde, Maria Tunset (Doktoravhandlinger ved NTNU, 1503-8181; 2012:282, Doctoral thesis, 2012)
      Brystkreft er den vanligste kreftformen blant kvinner i Norge. Prognose og overlevelse avhenger av type kreft, tumorstørrelse, lymfeknutemetastaser og reseptorstatus (østrogen, progesteron og HER2). Basert på genekspresjonanalyser ...
    • Effect of Glutaminase Inhibition in Basal-Like Patient-Derived Xenografts Analyzed by Magnetic Resonance Spectroscopy 

      Henriksen, Ida Marie (Master thesis, 2017)
      Breast cancer is today the leading cause for cancer related deaths among women in Europe. Decreased mortality among breast cancer patients has been observed over the last twenty years, where development and use of targeted ...
    • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

      Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 ...
    • Interplay of choline metabolites and genes in patient-derived breast cancer xenografts 

      Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr; Sitter, Beathe; Bathen, Tone; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Engebråten, Olav; Sørlie, Therese; Marangoni, Elisabetta; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2014)
      Introduction Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a large ...