Browsing NTNU Open by Author "Grill, Valdemar"
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Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
Hals, Ingrid Katrin; Rokstad, Anne Mari; Strand, Berit Løkensgard; Oberholzer, José; Grill, Valdemar (Journal article; Peer reviewed, 2013)Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ... -
LADA (latent autoimmune diabetes in adults) in Norway - occurence, risk factors, treatment and complications :
Carlsson, Sofia; Midthjell, Kristian; Grill, Valdemar (Journal article; Peer reviewed, 2013)LADA (latent autoimmune diabetes in adults) may be the most common form of autoimmune diabetes and thus encompasses a significant proportion of the diabetic population. Still, knowledge about this common form of diabetes ... -
On the susceptibility and adaptability of beta cells to stressful conditions: effects of nutrient scarcity, hyperoxia and internalization of amylin
Singh, Rinku (Doctoral theses at NTNU;2018:26, Doctoral thesis, 2018) -
Preconditioning with Associated Blocking of Ca2+ Inflow Alleviates Hypoxia-Induced Damage to Pancreatic β-Cells
Ma, ZH; Moruzzi, N; Catrina, SB; Hals, Ingrid Katrin; Oberholzer, J.; Grill, Valdemar; Björklund, A. (Journal article; Peer reviewed, 2013)Objective: Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact ... -
Saving β-Cells from Demise:Effects of in vitro Conditions and Genetic Engineering of UCP-2
Hals, Ingrid Kathrin (Doktoravhandlinger ved NTNU, 1503-8181; 2014:106, Doctoral thesis, 2014)Motverking av skade på β-celler: effekt av endra in vitro-forhold og genetisk manipulering av UCP-2 Beta (β)-cellene, som produserer insulin, ligg samla i såkalla Langerhanske (L) øyer i bukspyttkjertelen. Ved diabetes er ... -
Testing the flexibility of mitochondrial functioning in insulin-producing β-cells under diabetes like conditions in vitro
Kylling, Mari Slemmen (Master thesis, 2019)Bakgrunn: Kronisk hyperglykemi er skadelig for de insulinproduserende β-cellene i pankreas. Mitokondrienes funksjon i disse cellene er helt essensiell for at β-cellene skal fungere optimalt. Mitokondriene påvirkes trolig ...