Browsing NTNU Open by Author "Granlund, Atle van Beelen"
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C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn; Mollnes, Tom Eirik; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2018)The chemokine C-C motif ligand 20 (CCL20) is increased in the colonic mucosa during active inflammatory bowel disease (IBD) and can be found both in the epithelium and immune cells in the lamina propria. The present study ... -
Colonic mucosal gene expression in inflammatory bowel disease: From whole genome to REG gene family expression
Granlund, Atle van Beelen (Doktoravhandlinger ved NTNU, 1503-8181; 2013:111, Doctoral thesis, 2013)Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the digestive tract. The two main forms of IBD are ulcerative colitis (UC) and Crohn’s disease (CD). As IBD are chronic diseases, often with ... -
Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids
Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Peer reviewed, 2023) -
Differences between the HT29 and HT29- MTX epithelial cell lines - An analysis of gene expression data
Skovdahl, Helene Kolstad (Master thesis, 2016)Introduction: Epithelial cancerous cell lines are used in a wide variety of research because of the unique possibility to study isolated cellular mechanisms in detail. This can be used for wider understanding of pathological ... -
Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease
Thorsvik, Silje; Damås, Jan Kristian; Granlund, Atle van Beelen; Flo, Trude Helen; Bergh, Kåre; Østvik, Ann Elisabet; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2017)Background and Aim Accurate, noninvasive biomarkers are needed to diagnose and monitor inflammatory bowel disease (IBD). Neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin 2, is expressed in inflamed ... -
Genetic Engineering for Revealing Underlying Mechanisms of Inflammatory Bowel Diseases
Roseth, Ingrid Aass (Master thesis, 2020)Inflammatorisk tarmsykdom, også kalt IBD, er en samlebetegnelse på kronisk betennelse i tarmen. IBD består i hovedsak av ulcerøs kolitt og Crohns sykdom. De underliggende årsakene er i stor grad ukjent, men både genetikk, ... -
Identifying expression quantitative trait loci in patients with inflammatory bowel disease
Mathisen, Kristine Lund (Master thesis, 2019)Denne masteroppgaven er en pilotstudie for å undersøke forholdet mellom genotypede SNP og genuttrykket til et gen. Vi bruker genet ITGAL som et prototype-gen, og analyserer prøver fra individer med og uten kroniske ... -
The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course
Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Introduction: Fungal microbiota's involvement in the pathogenesis of Crohn's disease (CD) is incompletely understood. The terminal ileum is a predilection site both for primary involvement and recurrences of CD. We, ... -
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ... -
Karakterisering av ukonvensjonelle T-celler i IBD ved RNA-sekvensering
AL-Anbary, Morsalin Maythem (Master thesis, 2023)Inflammatorisk tarmsykdom (IBD) er en kompleks kronisk lidelse i mage-tarmkanalen med usikker patofysiologi. IBD omfatter to idiopatiske lidelser; Ulcerøs kolitt (UC) og Crohns sykdom (CD). Patofysiologi, progresjon og ... -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet (Peer reviewed; Journal article, 2021)Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ... -
Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration
Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias; Thorsvik, Silje; Flatberg, Arnar; Sporsheim, Bjørnar; Ostrop, Jenny; Mollnes, Tom Eirik; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2021)Treatment of inflammatory bowel disease (IBD) is challenging, with a series of available drugs each helping only a fraction of patients. Patients may face time-consuming drug trials while the disease is active, thus there ... -
Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease
Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen (Peer reviewed; Journal article, 2022)In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, ... -
Statistical methods for analysis of gene expression count data applied to a Crohn's disease dataset
Ankill, Sebastian Øiungen (Master thesis, 2022)Denne oppgaven er motivert av behovet for å bruke gyldige og sterke statistiske modeller og metoder for analyse av genuttrykksdata i medisin, spesielt når flere observasjoner fra samme individ er til stede i data. Det ... -
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium
Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2022)Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory ... -
Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease
Escudero-hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet; Munch, Andreas (Peer reviewed; Journal article, 2021)Background and aims: The pathophysiology of the inflammatory bowel disease collagenous colitis (CC) is poorly described. Our aim was to use RNA sequencing of mucosal samples from patients with active CC, CC in remission, ... -
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ... -
Verification of gene expression differences on a protein level - An IHC study
Skilbrigt, Ida Maria; Jensen, Sigrid Slettbakk (Master thesis, 2016)Background: Inflammatory bowel disease, a collective term that includes ulcerative colitis and Crohns disease, is an inflammatory disorder that affects the gastrointestinal tract, with symptoms like severe diarrea, pain, ... -
The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis
Escudero-Hernandez, Celia; Münch, Andreas; Østvik, Ann Elisabet; Granlund, Atle van Beelen; Koch, Stefan (Peer reviewed; Journal article, 2020)Background and Aims: Diarrhoea is a common, debilitating symptom of gastrointestinal disorders. Pathomechanisms probably involve defects in trans-epithelial water transport, but the role of aquaporin [AQP] family water ...