Blar i NTNU Open på forfatter "Grønbech, Jon Erik"
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Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial
Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik; Hemmingsson, Oskar; Isaksson, Bengt; Juel, Ingebjørg Soterud; Larsen, Peter Nørgaard; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Rizell, Magnus; Sandström, Per; Sandvik, Oddvar Mathias; Sparrelid, Ernesto; Taflin, Helena; Taskén, Kjetil; Brudvik, Kristoffer Watten; Fretland, Åsmund Avdem; Horn, Arild; Kleive, Dyre; Labori, Knut Jørgen; Lassen, Kristoffer; Røsok, Bård Ingvald; Søreide, Jon Arne; Tholfsen, Tore; Villanger, Olaug; Waage, Anne (Journal article; Peer reviewed, 2021)Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of ... -
Clinical Aspects in Translational Research on Gastric Tumorigenesis and Development of New Treatments
Andersen, Gøran Troseth (Doctoral theses at NTNU;2023:360, Doctoral thesis, 2023)Kliniske aspekter ved translasjonsforskning på magekreft og utvikling av nye behandlinger Bakgrunn/mål: Medisinsk translasjonsforskning er en toveis prosess for å redusere avstanden fra laboratoriet til sykesengen ved å ... -
Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer
Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik; Wang, Timothy Cragin; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ... -
Cumulative incidence of first recurrence after curative treatment of stage I–III colorectal cancer. Competing risk analyses of temporal and anatomic patterns
Storli, Per Even; Dille, Rachel; Skjærseth, Gaute Havik; Gran, Mads Vikhammer; Myklebust, Tor Åge; Grønbech, Jon Erik; Bringeland, Erling Audun (Peer reviewed; Journal article, 2023)Background Updated knowledge about the rates of recurrence and time to recurrence following curative treatment of colorectal cancer is essential to secure better patient information on prognosis, to serve as a premise ... -
Evaluation of Neoadjuvant Chemotherapy in Patients with Resectable Gastric Adenocarcinoma in Central Norway 2007 – 2016
Sandø, Alina Desiree (Doctoral theses at NTNU;2024:12, Doctoral thesis, 2024)This thesis presents three retrospective, population-based, observational studies on patients diagnosed with upfront resectable gastric adenocarcinoma and receiving neoadjuvant chemotherapy (NAC) in Central Norway during ... -
Gastric Adenocarcinoma in Central Norway: Incidence, treatment, and long term survival rates, with emphasis on outcomes after introducing perioperative chemotherapy
Bringeland, Erling A. (Doctoral thesis at NTNU;2016:261, Doctoral thesis, 2016)I løpet av de siste 20 årene er flere endringer gjort i utredning og behandling av pasienter fra Midt Norge med kreft i magesekken. Kartlegging av svulstomfang med snitt røntgen (CT) er standardisert, og selvekspanderende ... -
Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection.
Fossmark, Reidar; Balto, Tine Marie; Martinsen, Tom Christian; Grønbech, Jon Erik; Munkvold, Bjørn; Mjønes, Patricia; Waldum, Helge (Journal article; Peer reviewed, 2019)Background: Neuroendocrine tumours (NETs) in the ileum grow slowly but metastasise to the liver at an early stage. After resection of the primary tumour and mesenteric lymph nodes, selected patients with liver metastases ... -
Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Purpose: Hypergastrinemia increases the risk of developing proximal gastric adenocarcinoma. However, it is unclear if hypergastrinemia affects the survival in patients with gastric adenocarcinoma. This study aimed to examine ... -
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ... -
Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial
Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne; Mortensen, Kim Erlend; Smaaland, Rune; Sorbye, Halfdan; Verbeke, Caroline Sophie; Dueland, Svein (Journal article; Peer reviewed, 2017)Background: Pancreatic cancer is the fourth leading cause of cancer-related death. While surgical resection remains the foundation for potentially curative treatment, survival benefit is achieved with adjuvant oncological ... -
Neural signaling modulates metabolism of gastric cancer
Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis; Wang, Timothy Cragin; Lundgren, Steinar; Grønbech, Jon Erik; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that ... -
Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer
Sandø-Klemmetvoll, Alina Desiree; Fougner, Reidun; Røyset, Elin Synnøve; Dai, Hong Yan; Grønbech, Jon Erik; Bringeland, Erling Audun (Peer reviewed; Journal article, 2023)Background: The method of response evaluation following neoadjuvant chemotherapy (NAC) in resectable gastric cancer has been widely debated. An essential prerequisite is the ability to stratify patients into subsets of ... -
The value of restaging CT following neoadjuvant chemotherapy for resectable gastric cancer. A population-based study
Sandø, Alina Desiree; Fougner, Reidun; Grønbech, Jon Erik; Bringeland, Erling Audun (Journal article; Peer reviewed, 2021)Background Response evaluation following neoadjuvant chemotherapy (NAC) in gastric cancer is debated. The aim of this study was to investigate the value of UICC-downstaging as mode of response evaluation following a ...