• Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS 

      Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K (Journal article; Peer reviewed, 2015)
      Tumors develop an abnormal microenvironment during growth, and similar to the metastatic phenotype, the metabolic phenotype of cancer cells is tightly linked to characteristics of the tumor microenvironment (TME). In this ...
    • Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism 

      Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey (Journal article; Peer reviewed, 2016)
      Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ...
    • Metabolic reprogramming supports the invasive phenotype in malignant melanoma 

      Bettum, Ingrid Johanne; Gorad, Saurabh Sayajirao; Barkovskaya, Anna; Pettersen, Solveig; Moestue, Siver Andreas; Vasiliauskaite, Kotryna; Tenstad, Ellen; Øyjord, Tove Ragnhild; Risa, Øystein; Nygaard, Vigdis; Mælandsmo, Gunhild; Prasmickaite, Lina (Journal article; Peer reviewed, 2015)
      Invasiveness is a hallmark of aggressive cancer like malignant melanoma, and factors involved in acquisition or maintenance of an invasive phenotype are attractive targets for therapy. We investigated melanoma phenotype ...
    • The impact of oncogenic signaling on the metabolomics of melanoma and prostate cancer 

      Gorad, Saurabh Sayajirao (Doctoral thesis at NTNU;2016:15, Doctoral thesis, 2016)