Browsing NTNU Open by Author "Gidon, Alexandre"
Now showing items 1-9 of 9
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The Cyclooxygenase 2 inhibitor etoricoxib as adjunctive therapy in tuberculosis impairs macrophage control of mycobacterial growth
Nore, Kristin Grotle; Louet, Claire; Bugge, Marit; Gidon, Alexandre; Jørgensen, Marthe Jøntvedt; Jenum, Synne; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Flo, Trude Helen (Peer reviewed; Journal article, 2023)Background Current tuberculosis treatment regimens could be improved by adjunct host-directed therapies (HDT) targeting host responses. We investigated the antimycobacterial capacity of macrophages from patients with ... -
Establishment of an image analysis and acquisition platform used to test host-directed therapy in Mycobacterium avium infection
Andresen, Sunniva (Master thesis, 2021)Bakgrunn: Mycobacterium avium er en non-tuberkuløs mykobakterie (NTM), som er nært beslektet med Mycobacterium tuberculosis, som gir NTM lungesykdom. NTM infeksjon er vanskelig å behandle og krever en behandling med flere ... -
Metformin improves Mycobacterium avium infection by strengthening macrophage antimicrobial functions
Flo, Trude Helen; Gidon, Alexandre; Wahl, Sissel Gyrid Freim; Louet, Claire; Haug, Markus; Mediaas, Sindre Dahl (Peer reviewed; Journal article, 2024) -
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
Niyonzima, Nathalie; Rahman, Jubayer; Kunz, Natalie; West, Erin; Freiwald, Tilo; Desai, Jigar V.; Merle, Nicolas; Gidon, Alexandre; Sporsheim, Bjørnar; Lionakis, Michail S.; Evensen, Kristin; Lindberg, Beate; Skagen, Karolina; Skjelland, Mona; Singh, Parul; Haug, Markus; Ruseva, Marieta M.; Kolev, Martin; Bibby, Jack; Marshall, Olivia; O’Brien, Brett; Deeks, Nigel; Afzali, Behdad; Clark, Richard J.; Woodruff, Trent M.; Pryor, Mylton; Yang, Zhi-Hong; Remaley, Alan T.; Mollnes, Tom Eirik; Hewitt, Stephen M.; Yan, Bingyu; Kazemian, Majid; Kiss, Mate G.; Binder, Christoph J.; Halvorsen, Bente; Espevik, Terje; Kemper, Claudia (Peer reviewed; Journal article, 2021)While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. ... -
Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages
Gidon, Alexandre; Åsberg, Signe; Louet, Claire; Ryan, Liv; Haug, Markus; Flo, Trude Helen (Journal article; Peer reviewed, 2017)Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation through poorly understood mechanisms proposed to involve arrest of phagosomal maturation at an early endosomal stage. A ... -
Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages
Røst, Lisa M.; Louet, Claire; Bruheim, Per; Flo, Trude Helen; Gidon, Alexandre (Peer reviewed; Journal article, 2022)Macrophages deploy a variety of antimicrobial programs to contain mycobacterial infection. Upon activation, they undergo extensive metabolic reprogramming to meet an increase in energy demand, but also to support immune ... -
The Streptococcus agalactiae R3 surface protein is encoded by sar5
Basson, Adelle; Olaisen, Camilla; Selvik, Linn-Karina M.; Lyng, Randi Valsø; Lysvand, Hilde; Gidon, Alexandre; Ås, Christina Gabrielsen; Afset, Jan Egil; Dragset, Marte Singsås (Peer reviewed; Journal article, 2022)Streptococcus agalactiae (group B streptococcus; GBS) is an important human pathogen causing pneumonia, sepsis and meningitis in neonates, as well as infections in pregnant women, immunocompromised individuals, and the ... -
TLR9 Trafficking and Signaling
Cemalovic, Ena (Master thesis, 2019)Toll-like Receptor 9 (TLR9) is an endosomal receptor found highly expressed in B cells and plasmacytoid dendritic cells (pDCs). It is activated by unmethylated CpG DNA and synthetic CpG oligodeoxyribonucleotides (ODNs) to ... -
The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages
Gidon, Alexandre; Louet, Claire; Røst, Lisa M.; Bruheim, Per; Flo, Trude Helen (Peer reviewed; Journal article, 2021)Macrophages sense and respond to pathogens by induction of antimicrobial and inflammatory programs to alert other immune cells and eliminate the infectious threat. We have previously identified the transcription factor ...